Kechun Liu
2020-09-25
CURRICULUM VITAE
Kechun Liu, MD, Professor
Biology Institute of Shandong Academy of Sciences
Personal
Name: Kechun Liu
Date of Birth: 1964.11.24.
Mailing Address: Biology Institute of Shandong Academy of Sciences
No.28789 East Jingshi Road, Jinan, Shandong Province, 250103, China.
Mobile: +86-150-2000-9568
Fax: +86-531-82965634
Email: hliukch@sdas.org; liukechun2000@163.com
Education
2003.9-2006.7: MD, Traditional Chinese Pharmacology, Shandong University of Traditional Chinese Medicine, China.
1986.9-1989.7: MSc, Biochemistry, Biology Department, Shandong University, China.
1982.9 -1986.7: BSc, Botany, Biology Department, Shandong University, China.
Academic appointments at Biology Institute Shandong Academy of Sciences
2001.12-present: Professor
1997.10-2001.11: Associate Professor
1992.7-1997.9: Assistant Professor
1989.9-1992.7: Research Assistant
Administrative assignments
Director, Biology Institute of Shandong Academy of Sciences
Director, Shandong Biological Detection Technology Engineering Laboratory
Director, Shandong Engineering Technology Center of Human Disease Zebrafish Model and Drug Screening
Social and Academic Employment
Member, Industry Biochemistry and Molecular Biology Branch of the Chinese Society of Biochemistry and Molecular Biology
Member, Traditional Chinese and Natural Medicines Specialized Committee of Shandong Society of Medicine
Member, Biochemistry and Biotechnology Medicine Specialized Committee of Shandong Society of Medicine
Executive Member, Council of Experimental Animal Society of Shandong Province
Member, Council of Toxicology Society of Shandong Province
Editorial Board Member, Shandong Science
Moderator, Pharmacology and Toxicology Column of Shandong Science
Project Evaluation Expert, Ministry of Science and Technology
Research areas and summarized achievements
The overall aim of our research is to develop novel strategies for drug/natural source compounds screening and evaluation in vivo and in vitro, and to generate animal disease models for investigating mechanisms underlying cardiovascular diseases, neurological diseases, and cancers.
Research areas include:
(1) Disease model construction based on zebrafish and cell culture;
(2) Drug screening and safety evaluation;
(3) Discovery of natural active substances and their preparations;
(4) Safety evaluation of Environmental pollutants;
(5) Development of new drugs.
Scientific projects
• Science Foundation of the Ministry of Science and Technology: 5 items
• National Natural Science Foundation: 3 items
• Public Science and Technology Research Funds Projects of Ocean: 1 item
• Shandong Key Technical Development Projects: 18 items
Scientific awards
• The Third Award for National Science Development: 1 item
• The First Award for Shandong Science Development: 2 items
• The Second Award for Shandong Science Development: 1 item
• The Third Award for Shandong Science Development: 2 items
• National Invention and Entrepreneurship People Award: 1 item
• Shandong Invention and Entrepreneurship Award: 1 item
Research Projects (the last five years)
Title of Project: Study of Chinese medicine quality control technology and its applications based on biological effect and DNA identification (2018YFC1707303)
Funding Agency: National key research and development project
Period: 2018.12-2021.12
Direct Costs: ￥2,050,000
Title of Project: Research on large-scale preparative technique of marine polyunsaturated fatty acid phospholipids and Industrialization demonstration (201505030-2)
Funding Agency: National Oceanography, public service industry research specialized project
Period: 2015.01-2018.12
Direct Costs: ￥2,350,000
Title of Project: Research and development on key techniques for preparation of ω-3 phospholipid fatty acid and medical food
Funding Agency: Shandong key research and development project, marine medical food specialized project
Period: 2016-2018
Direct Costs: ￥1,000,000
Title of Project: Study of key techniques for preparation of pregnancy nutritional supplement of solid foods for special medical purpose and products research and development (2017YYSP032)
Funding Agency: Shandong key research and development project, medical food specialized project
Period: 2017-2019
Direct Costs: ￥800,000
Title of Project: Early stage of medicine preparation from innovative drugs, construction of key techniques for safety evaluation and its applications (2014ZZCX02105)
Funding Agency: Shandong independent innovation and achievement transformation specialized project
Period: 2014.1-2016.12
Direct Costs: ￥500,000
Selected Publications (the last five years)
1. Zhang, Y., Cen, J., Jia, Z., Hsiao, C. D., Xia, Q., Wang, X., Chen, X., Wang, R., Jiang, Z., Zhang, L. & Liu, K. (2019) Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish, Antimicrob Agents Chemother. 63.
2. Jin, M., Ji, X., Zhang, B., Sheng, W., Wang, R. & Liu, K. (2019) Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish, Ecotoxicol Environ Saf. 172, 460-470.
3. Jin, M., Xiao, Z., Zhang, S., Men, X., Li, X., Zhang, B., Zhou, T., Hsiao, C. D. & Liu, K. (2019) Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos, Chemosphere. 219, 557-566.
4. Han, L., Sheng, W., Li, X., Sik, A., Lin, H., Liu, K. & Wang, L. (2019) Novel carbohydrate modified berberine derivatives: synthesis and in vitro anti-diabetic investigation, Medchemcomm. 10, 598-605.
5. Zhang, S. S., Han, L. W., Shi, Y. P., Li, X. B., Zhang, X. M., Hou, H. R., Lin, H. W. & Liu, K. (2018) Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo, Mar Drugs. 16.
6. Zhang, Y., Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J. & Liu, K. (2019) The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae, Hum Exp Toxicol. 38, 36-44。
7. Li, X., Zhang, B., Li, N., Ji, X., Liu, K. & Jin, M. (2019) Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level, Chemosphere. 231, 315-325.
8. Zhang, Y., Li, J., Chen, Y., Han, L., He, Q., Chu, J. & Liu, K. (2019) The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by isopsoralen in zebrafish larvae, Hum Exp Toxicol. 38, 36-44.
9. Zhang, Y., Li, S., Li, J., Han, L., He, Q., Wang, R., Wang, X. & Liu, K. (2018) Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos, Chemosphere. 197, 611-621.
10. Jin, M., Sheng, W., Han, L., He, Q., Ji, X. & Liu, K. (2018) Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish, Fish Shellfish Immunol. 83, 26-36.
11. Jin, M., He, Q., Zhang, S., Cui, Y., Han, L. & Liu, K. (2018) Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish, Neurochem Res. 43, 904-917.
12. Xia, Q., Wei, L., Zhang, Y., Kong, H., Shi, Y., Wang, X., Chen, X., Han, L. & Liu, K. (2018) Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder, Front Pharmacol. 9, 1457.
13. Li, X., He, Q., Hou, H., Zhang, S., Zhang, X., Zhang, Y., Wang, X., Han, L. & Liu, K. (2018) Targeted lipidomics profiling of marine phospholipids from different resources by UPLC-Q-Exactive Orbitrap/MS approach, J Chromatogr B Analyt Technol Biomed Life Sci. 1096, 107-112.
14. Zou, Y., Zhang, Y., Han, L., He, Q., Hou, H., Han, J., Wang, X., Li, C., Cen, J. & Liu, K. (2017) Oxidative stress-mediated developmental toxicity induced by isoniazide in zebrafish embryos and larvae, J Appl Toxicol. 37, 842-852.
15. Zhang, Y., Han, L., He, Q., Chen, W., Sun, C., Wang, X., Chen, X., Wang, R., Hsiao, C. D. & Liu, K. (2017) A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish, J Pharmacol Toxicol Methods. 84, 102-110.
16. Zhang, C., Li, C., Chen, S., Li, Z., Jia, X., Wang, K., Bao, J., Liang, Y., Wang, X., Chen, M., Li, P., Su, H., Wan, J. B., Lee, S. M. Y., Liu, K. & He, C. (2017) Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways, Redox Biol. 11, 1-11.
Authorized Patents (the last five years)
1. Yun Zhang, Kechun Liu, Liwen Han, Qiuxia He, Xue Wang, Weibing Peng, Weiyun Chen, Ximin Wang, Hairong Hou, Xiqiang Chen. A method of screening compounds for protection of zebrafish liver funtion. 2018.07.24, China, ZL2015104867509.
2. Qiuxia He, Kechun Liu, Liwen Han, Jie Chu, Yun Zhang, Xue Wang, Ximin Wang, Shanshan Zhang. A device for acute toxicity evalution of compounds based on zebrafish model and its instruction. 2018.05.18, China, ZL2017101098091.
3. Liwen Han, Kechun Liu, Qiuxia He, Yun Zhang, Jian Han, Rongchun Wang, Chen Sun, Xue Wang, Hairong Hou, Weibing Peng, Weiyun Chen. A method for evalution of compounds on angiogenesis under pathological state. 2018.04.24, China, ZL2016106770273.
4. Yun Zhang, Kechun Liu, Liwen Han, Xue Wang, Qiuxia He, Chen Sun, Ximin Wang, Jie Chu, Jian Han, Rongchun Wang. A method for rapid evalution of compunds on zebrafish liver damage. 2018.01.26, China, ZL2015104871398.
5. Kechun Liu, Liwen Han, Yanqiang Yuan, Weibing Peng, Qiuxia He, Jie Chu, Xiqiang Chen. A extraction and purification method for anthocyanins of purple potato. 2016.05, China, ZL2014105633180.
6. Xiqiang Chen, Kechun Liu, Weibing Peng, Hairong Hou, Ximin Wang, Qiuxia He, Weiyun Chen, Rongchun Wang, Chen Sun, Yun Zhang. A device for learning and memory ability of zebrafish. 2014.12.24, China, ZL2014104993723.
7. Xue Wang, Kechun Liu, Liwen Han, Chen Sun, Jie Chu, Weibing Peng, Xiqiang Chen, Qiuxia He, Yun Zhang, Ximin Wang, Hairong Hou. A method of screening compounds for protection or improvement of renal funtion. 2014.11.12, China, ZL201410377736.0.
8. Xue Wang, Kechun Liu, Liwen Han, Xiqiang Chen, Qiuxia He, Weibing Peng, Ximin Wang, Hairong Hou, Yun Zhang, Chen Sun, Jie Chu. A method for evalution of compounds on nephrotoxicity via detection of creatinine of zebrafish tissues. 2014.10.29, China, ZL201410334259.X.
9. Kechun Liu, Liwen Han, Yanqiang Yuan, Qiuxia He, Sifeng Wang, Xiqiang Chen. A antitumor drug containing isolicoflavonol and its applications. 2015.04.22, China, ZL2011103774405.
10. Kechun Liu, Qiuxia He, Yanqiang Yuan, Liwen Han, Weibing Peng, Xiqiang Chen, Xue Wang, Ximin Wang, Hairong Hou. A method of screening active materials for anti-angiogenesis. 2014.04.2, China, ZL201110284414.8.
Honors or Awards (the last five years)
Title of Project: The evaluation technology of Chinese medicine on cardiovascular activities based on zebrafish model and its applications.
Awards: The Second Award, China Association of Chinese Medicine scientific and technological progress in 2016 (the First place).
Title of Project: The evaluation technology of Chinese patent medicine on cardiovascular activities based on zebra fish model and its applications.
Awards: The Second Award, Shandong Province scientific and technological progress in 2015 (the First place).
Title of Project: The establishment of technology for drug discovery based on zebrafish model and its applications.
Awards: The Third Award, Shandong Province scientific and technological progress in 2011 (the First place).
