Affiliation：

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences)

Contact details：

Telephone

15275129615

Email

xiaohan_0818@163.com 

Address

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), 28789 Jingshidong Road, Licheng District, Jinan 250103, Shandong Province, PR China

Biography

Dr. Yun Zhang is a Scientist at Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), a scientific research institution focusing on drug screening and biotechnology. She is a pharmacologist and toxicologist with a PhD in pharmacy. She mainly engaged in the research of drug screening and drug molecular toxicology. She has a good experience in screening and evaluating the activities of compounds using zebrafish models, mainly including anti-angiogenic activity, pro-angiogenic activity, anti-tumor metastasis activity (transplanted cancer model), organ protection activity (protecting cardiac, renal and liver), anti-apoptosis activity, and assay of acute toxicity, developmental toxicity, cardiotoxicity and hepatotoxicity. Her dissertation was focused on the acute toxicity, developmental toxicity and hepatotoxicity of drugs. She has published her research work in various peer reviewed journals. And she has applied for 18 patents, of which 6 were authorized. 

Research

Main research directions: one is to study the drug activity screening and drug action mechanism, and to carry out the drug evaluation work. The second is to study the toxicity, toxic mechanism and toxic components of drugs. 

Funding (year, title, source, amount, role)

1. 2018.01-2020.12, The mechanism of isoniazid inducing hepatotoxicity through endoplasmic reticulum stress-autophagy pathway in inflammatory state based on zebrafish model, National Natural Science Foundation of China, 201000 yuan, project leader.

2. 2015.07-2017.12, The hepatic toxicity of isoniazid under mild inflammation based on zebrafish model, Natural Science Foundation of Shandong Province, 50000 yuan, project leader.

Publications

1. Qing Xia, Kechun Liu, Zhili Jia, Xiaobin Li, Shanshan Zhang, Liwen Han, Guijin Sun, Chung-Der Hsiao, Yun Zhang*. The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish. Food Bioscience, 2020, 35. (corresponding author)

2. Juan Cen, Zhi-li Jia, Cheng-yue Zhu, Xue-fang Wang, Feng Zhang, Wei-yun Chen, Ke-chun Liu, Sai-yu Li, Yun Zhang*. Particulate matter (PM10) induces cardiovascular developmental toxicity in zebrafish embryos and larvae via the ERS, Nrf2 and Wnt pathways. Chemosphere. 2020; 250:126288. (corresponding author)

3. Yun Zhang, Chao Wang, Zhi-li Jia, Rui-jiao Ma, Xue-fang Wang, Wei-yun Chen, Ke-chun Liu*. Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway. Chemico-Biological Interactions. 2020, 316. (first author)

4. Wang Xue, Yang Xue-Liang, Liu Ke-Chun, Sheng Wen-Long, Xia Qing, Wang Rong-Chun, Chen Xi-Qiang, Zhang Yun*. Effects of streptozotocin on pancreatic islet β-cell apoptosis and glucose metabolism in zebrafish larvae. Fish physiology and biochemistry. 2020. Jan 28. doi: 10.1007/s10695-020-00769-w. (corresponding author)

5. Zhi-li Jia, Juan Cen, Jia-bo Wang, Feng Zhang, Qing Xia, Xue Wang, Xi-qiang Chen, Rong-chun Wang, Chung-der Hsiao, Ke-chun Liu, Yun Zhang*. Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae：Activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway. Chemosphere. 2019 Apr 6; 227:541-550. (corresponding author)

6. Yun Zhang, Juan Cen, Zhili Jia, Chung-Der Hsiao, Qing Xia, Xue Wang, Xiqiang Chen, Rongchun Wang, Zhenzhou Jiang, Luyong Zhang, Kechun Liu*. Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish. Antimicrob Agents Chemother. 2019 Apr 25; 63(5). (first author)

7. Yun Zhang, Yue Zhang, Juanjuan Li, Yiming Chen, Liwen Han, Qiuxia He, Ximin Wang, Jie Chu, Kechun Liu*. The role of hepatic antioxidant capacity and hepatobiliary transporter in liver injury induced by Isopsoralen in zebrafish larvae. Human and Experimental Toxicology. 2019, Vol. 38(1) 36–44. (first author)

8. Juan-juan Li, Yun Zhang*, et al., Tenacissoside H exerts an anti-inflammatory effect by regulating the nf-κb and p38 pathways in zebrafish. Fish Shellfish Immunol. 2018 Sep 10. doi: 10.1016/j.fsi.2018.09.032. (corresponding author)

9. Juanjuan Li1, Yun Zhang 1, *, Kechun Liu , Qiuxia He , Chen Sun , Jian Han , Liwen Han, Qingping Tian, Xiaoaiping induces developmental toxicity in zebrafish embryos through activation of ER stress, apoptosis and the Wnt pathway. Frontiers in pharmacology.2018. doi: 10.3389/fphar.2018.01250. (co-first author)

10. Yun Zhang*, Saiyu Li, Kechun Liu*, et al., Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos. Chemosphere. 2018. 197:611-621. (first author)

11. Yun Zhang, Liwen Han, Kechun Liu*, et al., A rapid assessment for predicting drug-induced hepatotoxicity using zebrafish. J Pharmacol Tox Met. 2017. 84:102-110. (first author)

12. Yu Zou1, Yun Zhang1, Kechun Liu*, et al., Oxidative stress-mediated developmental toxicity induced by isoniazide in zebrafish embryos and larvae. J Appl Toxicol. 2017. 37 (7): 842-852. (co-first author)

13. Yun Zhang, Kechun Liu, et al., Liver fatty acid binding protein deficiency provokes oxidative stress, inflammation and apoptosis-mediated hepatotoxicity induced by pyrazinamide in zebrafish larvae. Antimicrob Agents CH. 2016. 60(12):7347-7356. (first author)

14. Yun Zhang, Luyong Zhang, et al., Pyrazinamide induced hepatic injury in rats through inhibiting PPARα pathway. J Appl Toxicol. 2016. 6(2):579-590. (first author)

15. Yijing Su1, Yun Zhang1, Luyong Zhang, et al., Lipopolysaccharide exposure augments isoniazide-induced liver injury. J Appl Toxicol. 2014; 34 (12):1436-1442. (co-first author)

Patents

1. A method for rapid evaluation of the effects of compounds on liver function damage in zebrafish, ZL201510487139.8.

2. A method for screening active compounds with protective liver function in zebrafish, ZL201510486750.9.

3. A sampler and a working method of zebrafish larvae, ZL2016101735803.

Awards and other activities

1. Outstanding Scientific and technological Workers in Jinan in 2020.

2. First prize of Tai’an City science and technology progress award in 2019.

3. 2019 Jinan Academic Innovation Award of Natural Science.

Young editor: Chinese Herbal Medicines.

Editor: Current Chinese Medical Science, EC Pharmacology and Toxicology.

Reviewer:  Nanoscale, Journal of Hazardous Materials, Phytomedicine, Evidence-Based Complementary and Alternative Medicine, Drug and Chemical Toxicology, Food Chemistry.