Affiliation：

Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute of Shandong Academy of Sciences

Contact details

Telephone

+86-15169006695

Email

lixb@sdas.org

Address

Biology Institute of Shandong Academy of Sciences,

Jingshi East Road 28789,

Jinan,

Shandong,

250103, 

P. R. China

Biography

Xiaobin Li is currently the deputy director of the Drug Screening Laboratory in Biology Institute of Shandong Academy of Sciences,

She received her MSc in the field of natural product chemistry from the Jinan University (Guangzhou, China) in 2011, then graduated from Shandong University (Jinan, China) and got her PH.D degree with summa cum laude in the same field in 2015.

She is an associate researcher at Biology Institute of Shandong Academy of Sciences, China. Her current research focuses on the discovery of active natural products isolated from marine fungi and the composition and function of marine phospholipids.

She has undertaken 4 scientific research projects, including the National Natural Science Foundation of China, the Key R & D Program of Shandong Province, the major project of Bioengineering Technology Innovation Center of Shandong Province, and 2 projects from Shandong Academy of Sciences, with a total funding of ¥ 3.523 million. Besides, she has published more than 40 academic papers, including more than 30 SCI articles, and authorized 8 national invention patents.

Research

1. Discovery of cardiovascular active natural products from marine fungi by using chromatographic separation methods and zebrafish models

2. Study on the structures and activities of marine-derived phospholipids.

Funding (year, title, source, amount, role)

1. 2017.01-2019.12 Study on the bioactive constituents with pro-angiogenic effects from marine fungi under the guidance of the zebrafish model. National Natural Science Foundation of China (81602982), ¥ 173,000, PI. 

2. 2019.01-2020.12 Research on key technology of preparing the phospholipids with polyunsaturated fatty acid side chains using shrimp head waste as raw material. Key R & D Program of Shandong Province (2019GSF107053), ¥ 150,000, PI.

3. 2019.12-2021.12 The improvement of overall quality control technology and quality of Danshen compound preparation. Major Project of Bioengineering Technology Innovation Center of Shandong Province (2019JSWGCCXZX003), ¥ 3,000,000, PI.

4. 2017.12-2019.12 Quality evaluation of phospholipids with omega-3 fatty acid side chains from different sources based on lipidomics technology. Youth Foundation of Shandong Academy of Sciences (2018QN0026), ¥ 100,000, PI.

Selected Publications

1. Xiaobin Li, Chenyang Li, Yongqiang Zhu, Yongping Shi, Xuanming Zhang, Shanshan Zhang, Lizhen Wang, Houwen Lin, Hairong Hou, Chung-Der Hsiao, Liwen Han, Kechun Liu, Lipid fingerprinting of different material sources by UPLC-Q-Exactive Orbitrap/MS approach and their zebrafish-based activities comparison, Journal of Agricultural and Food Chemistry, 2020, 68, 2007-2015.

2. Xiao-Bin Li, Qiu-Xia He, Hai-Rong Hou, Shan-Shan Zhan, Xuan-Ming Zhang, Yun Zhang, Xi-Min Wang, Li-Wen Han, Ke-Chun Liu, Targeted lipidomics profiling of marine phospholipids from different resources by UPLC-Q-Exactive Orbitrap/MS approach, Journal of Chromatography B, 2018, 1096, 107-112.

3. Xiao-Bin Li, Lin Li, Rong-Xiu Zhu, Wei Li, Wen-Qiang Chang, Lu-Lu Zhang, Xiao-Ning Wang, Zun-Tian Zhao, Hong-Xiang Lou, Tetramic acids and pyridone alkaloids from an endolichenic fungus Tolypocladium cylindrosporum and their cytotoxic activity, Journal of Natural Products, 2015, 78 (9), 2155–2160.

4. Xiao-Bin Li, Wen-Qiang Chang, Sha Zheng, Wei Li, Hong-Xiang Lou, The cleavage of perylenequinones through photochemical oxidation acts as a detoxification mechanism for the producer, RSC Advances, 2015, 5 (36), 28187–28189. 

5. Xiao-Bin Li, Yan-Hui Zhou, Rong-Xiu Zhu, Wen-Qiang Chang, Hui-Qing Yuan, Wei Gao, Lu-Lu Zhang, Zun-Tian Zhao, Hong-Xiang Lou, Identification and biological evaluation of secondary metabolites from the endolichenic fungus Aspergillus versicolor, Chemistry & Biodiversity, 2015, 12 (4), 575–592.

6. Xiao-Bin Li, Yue-Lan Li, Jin-Chuan Zhou, Hui-Qing Yuan, Xiao-Ning Wang, Hong-Xiang Lou, A new diketopiperazine heterodimer from an endophytic fungus Aspergillus niger, Journal of Asian Natural Products Research, 2015, 17 (2), 182–187. 

7. Xiao-Bin Li, Fei Xie, Shan-Shan Liu, Ying Li, Jin-Chuan Zhou, Yong-Qing Liu, Hui-Qing Yuan, and Hong-Xiang Lou, Naphtho-γ-pyrones from endophyte Aspergillus niger occurring in the liverwort Heteroscyphus tener (Steph.) Schiffn., Chemistry & Biodiversity, 2013, 10 (7), 1193–1201.

8. Xiao-Bin Li, Jin-Shan Tang, Hao Gao, Rong Ding, Jia Li, Kui Hong, Xin-Sheng Yao. A new staurosporine analogue from Actinomycetes Streptomyces sp. (172614). J. Asian Nat. Prod. Res., 2011, 13 (8), 765–769.

Patents

1. Xiaobin Li, Liwen Han, Qiuxia He, et al.. Method for extracting high-purity -3 polyunsaturated fatty acid phospholipid from shrimp head: China patent ZL201611145839X, 2018-06-29.

2. Liwen Han, Xiaobin Li, Qiuxia He, et al.. Method for preparing high-purity marine polyunsaturated fatty acid phospholipid from cod viscera: China patent ZL2016111466659, 2018-06-01.

3. Kechun Liu, Xiaobin Li, Liwen Han, et al.. Method for extracting high-purity marine phospholipids from the Antarctic krill: China patent ZL2016111467030, 2018-06-29.

Other activities

 Part-time lecturer of Jining Medical College

 Member of Chinese Pharmaceutical Association, Chinese Chemical Society, Chinese Pharmacological Society, Chinese Toxicology Society, and Shandong Pharmaceutical Society

 Journal reviewer of Natural Products Research and Development and Applied Chemistry and Biochemistry Journal