Tai-Ping Fan
2020-09-25
Tai-Ping FAN, PhD FRSA
Fellow of the Royal Society of Arts
Chair Professor of China Medical University, Taiwan
Distinguished Professor of Northwest University, Xi’an, China
Retired Associate Professor and Head ofAngiogenesis & Natural Products Laboratory, Department of Pharmacology, University of Cambridge, United Kingdom
Nationality: British
Telephone: +44 7793 673 039 E-mail: tpf1000@icloud.com
Education/ Qualifications:
BSc (Upper Second Class Honours) in Pharmacology, University of London (1979);
PhD in Pharmacology, University of London (1982). “ Some Pharmacological Studies on the Inflammatory Mediators During Allograft Rejection” (Supervisor: Prof. G.P. Lewis)
Professional History:
July 1979 – June 1986. Postgraduate Research Assistant (1979-1982), Post-doctoral Research Fellow (1982-1985) and then Bernard Sunley Research Fellow (1985-1986), Department of Pharmacology, Institute of Basic Medical Sciences, University of London at Royal College of Surgeons of England. During this period, I developed a simple, rapid and reproducible method for quantitative studies of the vascular events (angiogenesis/neovascularisation, vasodilation and vascular shutdown) in skin graft healing and rejection using 133Xe injection. Concurrent histological and chemical analyses were used to establish the differential immumopharmacology of cyclosporine A (a powerful immunosuppressive agent derived from the fungus Tolypocladium inflatum) and synthetic anti-inflammatory agents (COX inhibitors) on the cellular events and inflammatory mediators (histamine, prostaglandins and cytokines) that are closely involved in transplant rejection. To investigate angiogenesis in depth, I successfully developed a rat sponge implant model as well as isolating, purifying and growing vascular endothelial cells in vitro.
July 1986 – September 2020. New Blood Lecturer (1986-1988), University Lecturer (Assistant Professor; 1988-2000) and then University Senior Lecturer (Associate Professor; 2001 until retirement on 30 Sept 2020) at the Department of Pharmacology, University of Cambridge. My major research activities include angiogenesis mechanisms, angiogenic peptides (IL-8, thymidine phosphorylase and VEGF), neuropeptides (substance P, angiotensin II, bradykinin) and natural products derived from traditional Chinese medicine (TCM; e.g. Panax ginseng, Angelica sinensis, Salvia miltiorrhizza) and other ethnic origins (e.g. Cinnamomum cassia, Centella asiatica).
In 2016-2017, I was invited by the Czech Ministry of Health to co-organise and chair an international meeting “Possible Synergies Between Western and Traditional Chinese Medicine” (Prague, February 2017), convincing the Czech Chamber of Deputies to incorporate TCM to be an integral part of Czech healthcare system in June 2017.
October 2020 and beyond. As a Distinguished Professor of the Northwest University (Xi’an, China) and in collaboration with colleagues in Cambridge and elsewhere, I am continuing to use multi-disciplinary approaches (pharmacology, botany, bioinformatics, bio- engineering, synthetic biology, standardization and regulation) to discover and optimize natural products aiming to elucidate their molecular targets and develop novel chemical drugs and/or botanical drugs with biotech or pharmaceutical companies.
One important R&D area is the prevention and treatment of diseases where there is excessive angiogenesis (e.g. cancer, atherosclerosis, diabetic retinopathy) or inadequate angiogenesis (e.g. myocardial infarct, chronic wound). With Prof. Xiaohui Zheng of Northwest University, we have developed Jun-Shi Medicinal Compatibility Model for discovering and patenting pro-angiogenic and anti-convulsant compounds derived from Salvia miltiorrhiza and Acorus tatarinowii, respectively, as well as elucidating their molecular mechanisms of action.
Significantly, we discovered a series of dihydroxylated phenolic acids e.g., D-danshensu (D-3,4-dihydroxyphenyllactic acid) and IDHP (Isopropyl- β-(3,4-dihydroxyphenyl)-α- hydroxypropanoate) to be endogenous compounds derived from DOPA (3,4- dihydroxyphenylalanine) with a multitude of pharmacological activities. IDHP possesses many pharmacological activities: vasorelaxation, protection against myocardial ischemia/reperfusion injury, attenuation of β-adrenoceptor mediated cardiac fibrosis. It is being developed as a potential therapeutic for vascular dementia and cerebral ischemia.
More recently, together with Prof. Yujie Cai of Jiangnan University (Wuxi, China), our team has successfully employed engineered E. coli and cell-free biosynthetic approach to generate D-danshensu (D-3,4-dihydroxyphenyllactic acid), rosmarinic acid and other natural products of therapeutic value. Appointed as the Chief Scientific Advisor of Biology Institute of Shandong Academy of Sciences (Jinan, China), I collaborate closely with Director Kechun Liu in establishing a comprehensive zebrafish-based platform of human diseases for evaluation of biological activities and safety profile of natural and synthetic chemicals.
In response to the COVID-19 outbreak, I have been collaborating with Authenmole Biotech and Zhejiang Chinese Medical University to develop high quality herbal teas for the prevention and treatment of coronavirus infection. Using patented Plant Low-temperature Extraction & Efficient Separation Integration Technology (PLEESIT), they have isolated pure phytochemicals from common edible plants (e.g. honeysuckle, dandelion, almond, ginger) and medicinal herbs (e.g. Houttuynia cordata, Atractylodes chinensis, Coriolus versicolor) while eliminating heavy metals and pesticide residues. Superior molecular extracts of established TCM prescriptions have been used to produce 4 standardised herbal teas for the prevention and treatment of COVID-19. Two formulations have been used to successfully protect front-line medical professionals, while the other two formulations have potentially saved patients in 4 hospitals in Wuhan, China. Currently I am participating in clinical evaluation of these and other herbal formulations used to combat COVID-19 and other diseases.
Citing “ In recognition of your contributions to the health and wellbeing sector though your innovative research on angiogenesis and traditional Chinese medicine”, the Royal Society of Arts elected me to its Fellowship (FRSA) in June 2021.
Starting August 2021, I joined forces with colleagues in China and Hong Kong SAR and use rare earth composite catalysts to manufacture granules for controlled release of low concentrations ClO2 gas (< 0.1 ppmv) via our patented air disinfection system. Independent studies have confirmed gaseous ClO2 is very effective in eradicating airborne viruses, bacteria and moulds in ambient air as well as sterilizing all surfaces, with no blind spots. Most significantly, this technology is being used to manufacture novel advanced materials for wide-ranging applications in clean healthy living, disease prevention, food security and environmental protection.
In July 2022, I was nominated for an International Award for Contribution to Chinese Medicine - Achievement Award in Medical Science of the World Federation of Chinese Medicine Societies (WFCMS). After two rounds of competitive selection procedure, I was further recommended by Professor Sir Tom Blundell (FRS, FMedSci, MAE) and short-listed for an on-line interview session in October 2022. With a PPT presentation entitled Towards the realization of key technologies for innovative drug discovery based on core bioactive molecules derived from the “TCM Liang Principle” for optimization of efficacy and safety, followed by an intensive Q&A session, I won the Second Prize on behalf of my 10-member international team.
In April 2023, I was invited by Academician Yang Huanming (the founder of Beijing Genomics Institute) to chair "Omics and TCM" session of the 18th International Genomics Conference (Zhangjiajie, Beijing, Nanjing, Wenzhou). Presenting a lecture " Advances in TCM Research and Development in the Big Data Era", I proposed the establishment of a Sino-European Centre for Phytopharmaceutical Research.
Prizes, Awards, Fellowships and Professorships:
“Shaanxi Province 100 Talents” Award, Xi’an, China (2015-present)
Qihuang International Prize from China Association of Chinese Medicine (2019)
Second Prize of International Award for Contribution to Chinese Medicine - Achievement Award in Medical Science of the World Federation of Chinese Medicine Societies (WFCMS) (2022)
The RMIT Foundation International Visiting Fellowship to RMIT University, Melbourne, Australia (Dec. 2013)
Fellow of the Royal Society of Arts (2021-present)
Chair Professor, China Medical University, Taiwan (2011-present)
Distinguished Professor of Northwest University, Xi’an, China (2015-present)
Distinguished Professor of Biology Institute of Shandong Academy of Sciences (Jinan, China (2020-present)
Honorary Professorships:
o Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China (1999-2002)
o Hong Kong Baptist University (2004-2007)
o Beijing Genomics Institute College (2017-2020)
Other Appointments and Affiliations
.Member of Emmanuel College Cambridge (1986–present)
.Lector in Pharmacology, Trinity College Cambridge (1990-2006)
.Deputy Co-ordinator of European Commission FP7 Project on Good Practice of Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM, 2009-2012), the EU’s first coordination action dedicated to TCM research (€1.1M)
.Visiting Professorships in China: Peking University, China (2006-2009); Northwest University, Xi’an (2010-present); Shanghai University of TCM (2011-present); Chengdu University of TCM (2012-2015); Xinjiang Medical University (2012-2015); Beijing University of Chinese Medicine (2013- present); China Academy of Chinese Medical Sciences Institute of Materia Medica (2014-present); Guangzhou University of TCM (2013-2016); Wenzhou Medical University (2018-present); Zhejiang Chinese Medical University (2019-present); Heilongjiang University of TCM (2019-present)
.Senior Vice President (UK) of the American Botanical Drug Association (https://www.botanicaldrug.org/team) (2020-present)
.Chairman, International Consortium of China Food & Drug Safety Blockchain Special Committee (2020-present)
Membership of Learned Societies
.British Pharmacological Society (1983-present)
.Honorary Member of the Chinese Pharmacological Society (Beijing), elected 1986
.British Association of Cancer Research (1987-present)
.Honorary Member of Association of Chinese Traditional Medicine (UK),1994
.Co-chair (2006 – present) of UK Chapter of the Consortium for Globalization of Chinese Medicine (https://www.tcmedicine.org)
.Secretary-General (2012-2014), President-Elect (2015-2016), President (2017-2018), Treasurer (2019-present) of The Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA; www.gp-tcm.org)
Editorial board, books and grant review etc
o Co-editor of “Textbook of Immunopharmacology” 3rd Edition, Blackwell, 1994
o Editor-in-Chief (1997-2005) and then Honorary Founding Editor (2005-present) of ANGIOGENESIS (2020 Impact Factor = 9.596), an international peer-reviewed journal devoted to the publication of top-quality original articles and reviews on the cellular and molecular mechanisms that regulate angiogenesis in physiological and pathological conditions. It also reports on novel therapeutic approaches for promoting or inhibiting angiogenesis as well as new markers and techniques for disease diagnosis and prognosis.
o Co-editor of "The New Angiotherapy" with Elise C. Kohn, Humana Press, 2002
o ad hoc journal reviewer for British Journal of Pharmacology, FASEB Journal, Biochemical Pharmacology, British Journal of Cancer, American Journal of Pathology, Laboratory Investigation, Immunology Letters
o ad hoc grant reviewer for the MRC, the Wellcome Trust, British Heart Foundation, Hong Kong University Grants Committee
o Guest Project Editor of a 3-part AAAS/Science Special Supplement on “The Art and Science of Traditional Medicine” (2014-2015) I was commissioned to lead an international team to write, edit and produce this unique collection of perspectives focusing on recent advances and future developments in the R&D, standardization, safety and regulation of materia medica used in traditional medicine from different ethnic origins (Asia, the Middle East, Africa, Europe and the America).
o Part 1: TCM Today - A Case for Integration
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-1-tcm-
today---case-integration
o Part 2: Multidisciplinary Approaches for Studying Traditional Medicine
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-2- multidisciplinary-approaches
o Part 3: The Global Impact of Traditional Medicine
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-3-global- impact-traditional-medicine
o Executive Deputy Editor-in-Chief, Journal of Traditional Chinese Medical Sciences (2020-present)
https://www.journals.elsevier.com/journal-of-traditional-chinese-medical-sciences/
Plenary lectures at major international conferences
In addition to 500-plus invited lectures and seminars at international conferences, companies, universities and research institutes in the UK, Europe (Austria, Belgium, the Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Luxembourg, the Netherlands, Portugal, Switzerland), Russia, China (including Taiwan, Hong Kong and Macao), Japan, Korea, the Philippines, Singapore, Australia, Canada, the USA and Bermuda, I have had the honour of giving plenary lectures as follows:
. Plenary Lecture “Angiogenesis: a promising target for therapy” at 7th Southeast Asia- Western Pacific Regional Meeting of Pharmacologists (Manila, Nov. 1995)
. Plenary Lecture “Angiogenesis: from plants to blood vessels” Plenary Lecture at IUPHAR 2006 -- 15th World Congress of Pharmacology (Beijing, July 2006)
. Plenary Lecture “New Pharmacology Inspired by Traditional Chinese Medicine” at 8th World Congress of Chinese Medicine (London, Sep. 2011)
. Plenary Lecture “Health and Healing Through Evidence-based Applications of Traditional Medicine” in United Nations Academic Impact (UNAI) Conference entitled “Skills and Technology Accelerating Rapid Transformation” (START) at United Nations Headquarters (New York, 8 July 2015). Lecture can be viewed at ~40 min on http://webtv.un.org/meetings-events/watch/part-2-amrita-university-event-an-international-conference-on-technology-for-sustainable-development/4346071033001 or https://www.youtube.com/watch?v=wplXt9iNixo
Links
LinkedIn https://www.linkedin.com/in/tai-ping-fan-aa651711/
Twitter https://twitter.com/GPTCMRA2017
List of publications
.PubMed
https://pubmed.ncbi.nlm.nih.gov/?term=Fan_TP&sort=date
.A large number of my publications can be downloaded from ResearchGate
https://www.researchgate.net/profile/Tai-Ping_Fan/publications/
.Google Scholar citations
https://scholar.google.co.uk/citations?user=NzK2TBcAAAAJ&hl=en
Fellow of the Royal Society of Arts
Chair Professor of China Medical University, Taiwan
Distinguished Professor of Northwest University, Xi’an, China
Retired Associate Professor and Head ofAngiogenesis & Natural Products Laboratory, Department of Pharmacology, University of Cambridge, United Kingdom
Nationality: British
Telephone: +44 7793 673 039 E-mail: tpf1000@icloud.com
Education/ Qualifications:
BSc (Upper Second Class Honours) in Pharmacology, University of London (1979);
PhD in Pharmacology, University of London (1982). “ Some Pharmacological Studies on the Inflammatory Mediators During Allograft Rejection” (Supervisor: Prof. G.P. Lewis)
Professional History:
July 1979 – June 1986. Postgraduate Research Assistant (1979-1982), Post-doctoral Research Fellow (1982-1985) and then Bernard Sunley Research Fellow (1985-1986), Department of Pharmacology, Institute of Basic Medical Sciences, University of London at Royal College of Surgeons of England. During this period, I developed a simple, rapid and reproducible method for quantitative studies of the vascular events (angiogenesis/neovascularisation, vasodilation and vascular shutdown) in skin graft healing and rejection using 133Xe injection. Concurrent histological and chemical analyses were used to establish the differential immumopharmacology of cyclosporine A (a powerful immunosuppressive agent derived from the fungus Tolypocladium inflatum) and synthetic anti-inflammatory agents (COX inhibitors) on the cellular events and inflammatory mediators (histamine, prostaglandins and cytokines) that are closely involved in transplant rejection. To investigate angiogenesis in depth, I successfully developed a rat sponge implant model as well as isolating, purifying and growing vascular endothelial cells in vitro.
July 1986 – September 2020. New Blood Lecturer (1986-1988), University Lecturer (Assistant Professor; 1988-2000) and then University Senior Lecturer (Associate Professor; 2001 until retirement on 30 Sept 2020) at the Department of Pharmacology, University of Cambridge. My major research activities include angiogenesis mechanisms, angiogenic peptides (IL-8, thymidine phosphorylase and VEGF), neuropeptides (substance P, angiotensin II, bradykinin) and natural products derived from traditional Chinese medicine (TCM; e.g. Panax ginseng, Angelica sinensis, Salvia miltiorrhizza) and other ethnic origins (e.g. Cinnamomum cassia, Centella asiatica).
In 2016-2017, I was invited by the Czech Ministry of Health to co-organise and chair an international meeting “Possible Synergies Between Western and Traditional Chinese Medicine” (Prague, February 2017), convincing the Czech Chamber of Deputies to incorporate TCM to be an integral part of Czech healthcare system in June 2017.
October 2020 and beyond. As a Distinguished Professor of the Northwest University (Xi’an, China) and in collaboration with colleagues in Cambridge and elsewhere, I am continuing to use multi-disciplinary approaches (pharmacology, botany, bioinformatics, bio- engineering, synthetic biology, standardization and regulation) to discover and optimize natural products aiming to elucidate their molecular targets and develop novel chemical drugs and/or botanical drugs with biotech or pharmaceutical companies.
One important R&D area is the prevention and treatment of diseases where there is excessive angiogenesis (e.g. cancer, atherosclerosis, diabetic retinopathy) or inadequate angiogenesis (e.g. myocardial infarct, chronic wound). With Prof. Xiaohui Zheng of Northwest University, we have developed Jun-Shi Medicinal Compatibility Model for discovering and patenting pro-angiogenic and anti-convulsant compounds derived from Salvia miltiorrhiza and Acorus tatarinowii, respectively, as well as elucidating their molecular mechanisms of action.
Significantly, we discovered a series of dihydroxylated phenolic acids e.g., D-danshensu (D-3,4-dihydroxyphenyllactic acid) and IDHP (Isopropyl- β-(3,4-dihydroxyphenyl)-α- hydroxypropanoate) to be endogenous compounds derived from DOPA (3,4- dihydroxyphenylalanine) with a multitude of pharmacological activities. IDHP possesses many pharmacological activities: vasorelaxation, protection against myocardial ischemia/reperfusion injury, attenuation of β-adrenoceptor mediated cardiac fibrosis. It is being developed as a potential therapeutic for vascular dementia and cerebral ischemia.
More recently, together with Prof. Yujie Cai of Jiangnan University (Wuxi, China), our team has successfully employed engineered E. coli and cell-free biosynthetic approach to generate D-danshensu (D-3,4-dihydroxyphenyllactic acid), rosmarinic acid and other natural products of therapeutic value. Appointed as the Chief Scientific Advisor of Biology Institute of Shandong Academy of Sciences (Jinan, China), I collaborate closely with Director Kechun Liu in establishing a comprehensive zebrafish-based platform of human diseases for evaluation of biological activities and safety profile of natural and synthetic chemicals.
In response to the COVID-19 outbreak, I have been collaborating with Authenmole Biotech and Zhejiang Chinese Medical University to develop high quality herbal teas for the prevention and treatment of coronavirus infection. Using patented Plant Low-temperature Extraction & Efficient Separation Integration Technology (PLEESIT), they have isolated pure phytochemicals from common edible plants (e.g. honeysuckle, dandelion, almond, ginger) and medicinal herbs (e.g. Houttuynia cordata, Atractylodes chinensis, Coriolus versicolor) while eliminating heavy metals and pesticide residues. Superior molecular extracts of established TCM prescriptions have been used to produce 4 standardised herbal teas for the prevention and treatment of COVID-19. Two formulations have been used to successfully protect front-line medical professionals, while the other two formulations have potentially saved patients in 4 hospitals in Wuhan, China. Currently I am participating in clinical evaluation of these and other herbal formulations used to combat COVID-19 and other diseases.
Citing “ In recognition of your contributions to the health and wellbeing sector though your innovative research on angiogenesis and traditional Chinese medicine”, the Royal Society of Arts elected me to its Fellowship (FRSA) in June 2021.
Starting August 2021, I joined forces with colleagues in China and Hong Kong SAR and use rare earth composite catalysts to manufacture granules for controlled release of low concentrations ClO2 gas (< 0.1 ppmv) via our patented air disinfection system. Independent studies have confirmed gaseous ClO2 is very effective in eradicating airborne viruses, bacteria and moulds in ambient air as well as sterilizing all surfaces, with no blind spots. Most significantly, this technology is being used to manufacture novel advanced materials for wide-ranging applications in clean healthy living, disease prevention, food security and environmental protection.
In July 2022, I was nominated for an International Award for Contribution to Chinese Medicine - Achievement Award in Medical Science of the World Federation of Chinese Medicine Societies (WFCMS). After two rounds of competitive selection procedure, I was further recommended by Professor Sir Tom Blundell (FRS, FMedSci, MAE) and short-listed for an on-line interview session in October 2022. With a PPT presentation entitled Towards the realization of key technologies for innovative drug discovery based on core bioactive molecules derived from the “TCM Liang Principle” for optimization of efficacy and safety, followed by an intensive Q&A session, I won the Second Prize on behalf of my 10-member international team.
In April 2023, I was invited by Academician Yang Huanming (the founder of Beijing Genomics Institute) to chair "Omics and TCM" session of the 18th International Genomics Conference (Zhangjiajie, Beijing, Nanjing, Wenzhou). Presenting a lecture " Advances in TCM Research and Development in the Big Data Era", I proposed the establishment of a Sino-European Centre for Phytopharmaceutical Research.
Prizes, Awards, Fellowships and Professorships:
“Shaanxi Province 100 Talents” Award, Xi’an, China (2015-present)
Qihuang International Prize from China Association of Chinese Medicine (2019)
Second Prize of International Award for Contribution to Chinese Medicine - Achievement Award in Medical Science of the World Federation of Chinese Medicine Societies (WFCMS) (2022)
The RMIT Foundation International Visiting Fellowship to RMIT University, Melbourne, Australia (Dec. 2013)
Fellow of the Royal Society of Arts (2021-present)
Chair Professor, China Medical University, Taiwan (2011-present)
Distinguished Professor of Northwest University, Xi’an, China (2015-present)
Distinguished Professor of Biology Institute of Shandong Academy of Sciences (Jinan, China (2020-present)
Honorary Professorships:
o Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China (1999-2002)
o Hong Kong Baptist University (2004-2007)
o Beijing Genomics Institute College (2017-2020)
Other Appointments and Affiliations
.Member of Emmanuel College Cambridge (1986–present)
.Lector in Pharmacology, Trinity College Cambridge (1990-2006)
.Deputy Co-ordinator of European Commission FP7 Project on Good Practice of Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM, 2009-2012), the EU’s first coordination action dedicated to TCM research (€1.1M)
.Visiting Professorships in China: Peking University, China (2006-2009); Northwest University, Xi’an (2010-present); Shanghai University of TCM (2011-present); Chengdu University of TCM (2012-2015); Xinjiang Medical University (2012-2015); Beijing University of Chinese Medicine (2013- present); China Academy of Chinese Medical Sciences Institute of Materia Medica (2014-present); Guangzhou University of TCM (2013-2016); Wenzhou Medical University (2018-present); Zhejiang Chinese Medical University (2019-present); Heilongjiang University of TCM (2019-present)
.Senior Vice President (UK) of the American Botanical Drug Association (https://www.botanicaldrug.org/team) (2020-present)
.Chairman, International Consortium of China Food & Drug Safety Blockchain Special Committee (2020-present)
Membership of Learned Societies
.British Pharmacological Society (1983-present)
.Honorary Member of the Chinese Pharmacological Society (Beijing), elected 1986
.British Association of Cancer Research (1987-present)
.Honorary Member of Association of Chinese Traditional Medicine (UK),1994
.Co-chair (2006 – present) of UK Chapter of the Consortium for Globalization of Chinese Medicine (https://www.tcmedicine.org)
.Secretary-General (2012-2014), President-Elect (2015-2016), President (2017-2018), Treasurer (2019-present) of The Good Practice in Traditional Chinese Medicine Research Association (GP-TCM RA; www.gp-tcm.org)
Editorial board, books and grant review etc
o Co-editor of “Textbook of Immunopharmacology” 3rd Edition, Blackwell, 1994
o Editor-in-Chief (1997-2005) and then Honorary Founding Editor (2005-present) of ANGIOGENESIS (2020 Impact Factor = 9.596), an international peer-reviewed journal devoted to the publication of top-quality original articles and reviews on the cellular and molecular mechanisms that regulate angiogenesis in physiological and pathological conditions. It also reports on novel therapeutic approaches for promoting or inhibiting angiogenesis as well as new markers and techniques for disease diagnosis and prognosis.
o Co-editor of "The New Angiotherapy" with Elise C. Kohn, Humana Press, 2002
o ad hoc journal reviewer for British Journal of Pharmacology, FASEB Journal, Biochemical Pharmacology, British Journal of Cancer, American Journal of Pathology, Laboratory Investigation, Immunology Letters
o ad hoc grant reviewer for the MRC, the Wellcome Trust, British Heart Foundation, Hong Kong University Grants Committee
o Guest Project Editor of a 3-part AAAS/Science Special Supplement on “The Art and Science of Traditional Medicine” (2014-2015) I was commissioned to lead an international team to write, edit and produce this unique collection of perspectives focusing on recent advances and future developments in the R&D, standardization, safety and regulation of materia medica used in traditional medicine from different ethnic origins (Asia, the Middle East, Africa, Europe and the America).
o Part 1: TCM Today - A Case for Integration
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-1-tcm-
today---case-integration
o Part 2: Multidisciplinary Approaches for Studying Traditional Medicine
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-2- multidisciplinary-approaches
o Part 3: The Global Impact of Traditional Medicine
https://www.science.org/content/resource/art-and-science-traditional-medicine-part-3-global- impact-traditional-medicine
o Executive Deputy Editor-in-Chief, Journal of Traditional Chinese Medical Sciences (2020-present)
https://www.journals.elsevier.com/journal-of-traditional-chinese-medical-sciences/
Plenary lectures at major international conferences
In addition to 500-plus invited lectures and seminars at international conferences, companies, universities and research institutes in the UK, Europe (Austria, Belgium, the Czech Republic, Denmark, Finland, France, Germany, Greece, Italy, Luxembourg, the Netherlands, Portugal, Switzerland), Russia, China (including Taiwan, Hong Kong and Macao), Japan, Korea, the Philippines, Singapore, Australia, Canada, the USA and Bermuda, I have had the honour of giving plenary lectures as follows:
. Plenary Lecture “Angiogenesis: a promising target for therapy” at 7th Southeast Asia- Western Pacific Regional Meeting of Pharmacologists (Manila, Nov. 1995)
. Plenary Lecture “Angiogenesis: from plants to blood vessels” Plenary Lecture at IUPHAR 2006 -- 15th World Congress of Pharmacology (Beijing, July 2006)
. Plenary Lecture “New Pharmacology Inspired by Traditional Chinese Medicine” at 8th World Congress of Chinese Medicine (London, Sep. 2011)
. Plenary Lecture “Health and Healing Through Evidence-based Applications of Traditional Medicine” in United Nations Academic Impact (UNAI) Conference entitled “Skills and Technology Accelerating Rapid Transformation” (START) at United Nations Headquarters (New York, 8 July 2015). Lecture can be viewed at ~40 min on http://webtv.un.org/meetings-events/watch/part-2-amrita-university-event-an-international-conference-on-technology-for-sustainable-development/4346071033001 or https://www.youtube.com/watch?v=wplXt9iNixo
Links
LinkedIn https://www.linkedin.com/in/tai-ping-fan-aa651711/
Twitter https://twitter.com/GPTCMRA2017
List of publications
.PubMed
https://pubmed.ncbi.nlm.nih.gov/?term=Fan_TP&sort=date
.A large number of my publications can be downloaded from ResearchGate
https://www.researchgate.net/profile/Tai-Ping_Fan/publications/
.Google Scholar citations
https://scholar.google.co.uk/citations?user=NzK2TBcAAAAJ&hl=en
Tai-Ping Fan’s publications
1. Zhu Y, Yang H, Han L, Mervin LH, Hosseini-Gerami L, Li P, Wright P, Trapotsi MA, Liu K, Fan TP*, Bender A. In silico prediction and biological assessment of novel angiogenesis modulators from traditional Chinese medicine. Front Pharmacol. 2023 Feb 3;14:1116081. doi: 10.3389/fphar.2023.1116081. PMID: 36817116; PMCID: PMC9937659.
2. Deng H, Liang X, Liu J, Zheng X, Fan TP, Cai Y. Advances and perspectives on perylenequinone biosynthesis. Front Microbiol. 2022 Dec 20;13:1070110. doi: 10.3389/fmicb.2022.1070110. PMID: 36605511; PMCID: PMC9808054.
3. Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023 Jan;108:154520. doi: 10.1016/j.phymed.2022.154520. Epub 2022 Oct 22. PMID: 36334386.
4. Bai Y, Jia P, Zhao Y, Yang L, Wang X, Wang X, Wang J, Zhong N, Deng H, Du L, Fang J, Xue Y, Chen Y, Gao S, Feng Y, Yan Y, Xiong T, Liu J, Sun Y, Xie J, He X, An X, Liu P, Xu J, Qin F, Meng X, Yin Q, Yang Q, Gao R, Gao X, Luo K, Li Q, Wang X, Liang J, Yang P, Zhang Y, Liao S, Wang S, Zhao X, Xiao C, Yu J, Liu Q, Wang R, Peng N, Wang X, Guo J, Li X, Liu H, Bai Y, Li Z, Zhang Y, Nan Y, Zhang Q, Zhang X, Lei J, Alberts E, de Man A, Kim HK, Hsu SJ, Jia YS, Riener J, Zheng J, Zhang W, Zheng X, Cai Y, Wang M, Fan TP*, Zheng X. Discovery and therapeutic implications of bioactive dihydroxylated phenolic acids in patients with severe heart disease and conditions associated with inflammation and hypoxia. Pharmacol Res. 2022 Nov;185:106458. doi: 10.1016/j.phrs.2022.106458. Epub 2022 Sep 21. PMID: 36152740.
5. Liang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system. Appl Microbiol Biotechnol. 2022 Sep;106(17):5479-5493. doi: 10.1007/s00253-022-12110-x. Epub 2022 Aug 6. PMID: 35931895.
6. Fu CC, Xu FY, Qian YC, Koo HL, Duan YF, Weng GM, Fan TP, Chen MX, Zhu FY. Secondary Metabolites of Osmanthus fragrans: Metabolism and Medicinal Value. Front Pharmacol. 2022 Jul 18;13:922204. doi: 10.3389/fphar.2022.922204. PMID: 35924042; PMCID: PMC9340074.
7. Liang X, Deng H, Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Overexpression and biochemical characterization of a carboxyspermidine dehydrogenase from Agrobacterium fabrum str. C58 and its application to carboxyspermidine production. J Sci Food Agric. 2022 Jul;102(9):3858-3868. doi: 10.1002/jsfa.11735. Epub 2022 Jan 5. PMID: 34932223.
8. Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Biosynthesis of phenylpyruvic acid from l- phenylalanine using chromosomally engineered Escherichia coli. BiotechnolAppl Biochem. 2022 Oct;69(5):1909-1916. doi: 10.1002/bab.2256. Epub 2021 Oct 12. PMID: 34554609.
9. Liu D, Gou L, Bai Y, Fan TP, Zheng X, Cai Y. Converting the 3-quinuclidinone reductase from Agrobacterium tumefaciens into the ethyl 4-chloroacetoacetate reductase by site-directed mutagenesis. BiotechnolAppl Biochem. 2022 Aug;69(4):1428-1437. doi: 10.1002/bab.2214. Epub 2021 Jul 5. PMID: 34148265.
10. Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID: 33643049; PMCID: PMC7902932.
11. Li Y, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity. Biotechnol Appl Biochem. 2022 Dec;69(6):2530-2539. doi: 10.1002/bab.2302. Epub 2021 Dec 24. PMID: 34902878.
12. Mohamad Zobir SZ, Choi RJ, Modos D, Fan TP, Bender A. Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology. Synergy 11, Supplement, December 2020, 100073. https://doi.org/10.1016/j.synres.2021.100073
13. KalantarMotamedi Y, Choi RJ, Koh SB, Bramhall JL, Fan TP, Bender A. Prediction and identification of synergistic compound combinations against pancreatic cancer cells. iScience. 2021 Sep 3;24(9):103080. doi: 10.1016/j.isci.2021.103080. PMID: 34585118; PMCID: PMC8456050.
14. Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce (including Fan TP); Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. PMID: 33510482; PMCID: PMC7841765.
15. Deng H, Liang W, Fan TP, Zheng X, Cai Y. Modular engineering of Shiraia bambusicola for hypocrellin production through an efficient CRISPR system. Int J Biol Macromol. 2020 Dec 15;165(Pt A):796-803. doi:10.1016/j.ijbiomac.2020.09.208. Epub 2020 Sep 30. PMID: 33010268.
16. Liu J, Bai Y, Fan TP, Zheng X, Cai Y. Unveiling the Multipath Biosynthesis Mechanism of 2-Phenylethanol in Proteus mirabilis. JAgric Food Chem. 2020 Jul 22;68(29):7684-7690. doi: 10.1021/acs.jafc.0c02918. Epub 2020 Jul 10. PMID: 32608230.
17. Hu X, Bai Y, Fan TP, Zheng X, Cai Y. A novel type alanine dehydrogenase fromHelicobacter aurati: Molecular characterization and application. Int J Biol Macromol. 2020 Oct 15;161:636-642. doi: 10.1016/j.ijbiomac.2020.06.067. Epub 2020 Jun 10. PMID: 32534087.
18. Liang W, Xiong T, Wang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. A novel feruloyl esterase with high rosmarinic acid hydrolysis activity from Bacillus pumilus W3. Int J Biol Macromol. 2020 Oct 15;161:525-530. doi:10.1016/j.ijbiomac.2020.06.038. Epub 2020 Jun 9. PMID: 32531366.
1. Zhu Y, Yang H, Han L, Mervin LH, Hosseini-Gerami L, Li P, Wright P, Trapotsi MA, Liu K, Fan TP*, Bender A. In silico prediction and biological assessment of novel angiogenesis modulators from traditional Chinese medicine. Front Pharmacol. 2023 Feb 3;14:1116081. doi: 10.3389/fphar.2023.1116081. PMID: 36817116; PMCID: PMC9937659.
2. Deng H, Liang X, Liu J, Zheng X, Fan TP, Cai Y. Advances and perspectives on perylenequinone biosynthesis. Front Microbiol. 2022 Dec 20;13:1070110. doi: 10.3389/fmicb.2022.1070110. PMID: 36605511; PMCID: PMC9808054.
3. Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023 Jan;108:154520. doi: 10.1016/j.phymed.2022.154520. Epub 2022 Oct 22. PMID: 36334386.
4. Bai Y, Jia P, Zhao Y, Yang L, Wang X, Wang X, Wang J, Zhong N, Deng H, Du L, Fang J, Xue Y, Chen Y, Gao S, Feng Y, Yan Y, Xiong T, Liu J, Sun Y, Xie J, He X, An X, Liu P, Xu J, Qin F, Meng X, Yin Q, Yang Q, Gao R, Gao X, Luo K, Li Q, Wang X, Liang J, Yang P, Zhang Y, Liao S, Wang S, Zhao X, Xiao C, Yu J, Liu Q, Wang R, Peng N, Wang X, Guo J, Li X, Liu H, Bai Y, Li Z, Zhang Y, Nan Y, Zhang Q, Zhang X, Lei J, Alberts E, de Man A, Kim HK, Hsu SJ, Jia YS, Riener J, Zheng J, Zhang W, Zheng X, Cai Y, Wang M, Fan TP*, Zheng X. Discovery and therapeutic implications of bioactive dihydroxylated phenolic acids in patients with severe heart disease and conditions associated with inflammation and hypoxia. Pharmacol Res. 2022 Nov;185:106458. doi: 10.1016/j.phrs.2022.106458. Epub 2022 Sep 21. PMID: 36152740.
5. Liang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system. Appl Microbiol Biotechnol. 2022 Sep;106(17):5479-5493. doi: 10.1007/s00253-022-12110-x. Epub 2022 Aug 6. PMID: 35931895.
6. Fu CC, Xu FY, Qian YC, Koo HL, Duan YF, Weng GM, Fan TP, Chen MX, Zhu FY. Secondary Metabolites of Osmanthus fragrans: Metabolism and Medicinal Value. Front Pharmacol. 2022 Jul 18;13:922204. doi: 10.3389/fphar.2022.922204. PMID: 35924042; PMCID: PMC9340074.
7. Liang X, Deng H, Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Overexpression and biochemical characterization of a carboxyspermidine dehydrogenase from Agrobacterium fabrum str. C58 and its application to carboxyspermidine production. J Sci Food Agric. 2022 Jul;102(9):3858-3868. doi: 10.1002/jsfa.11735. Epub 2022 Jan 5. PMID: 34932223.
8. Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Biosynthesis of phenylpyruvic acid from l- phenylalanine using chromosomally engineered Escherichia coli. BiotechnolAppl Biochem. 2022 Oct;69(5):1909-1916. doi: 10.1002/bab.2256. Epub 2021 Oct 12. PMID: 34554609.
9. Liu D, Gou L, Bai Y, Fan TP, Zheng X, Cai Y. Converting the 3-quinuclidinone reductase from Agrobacterium tumefaciens into the ethyl 4-chloroacetoacetate reductase by site-directed mutagenesis. BiotechnolAppl Biochem. 2022 Aug;69(4):1428-1437. doi: 10.1002/bab.2214. Epub 2021 Jul 5. PMID: 34148265.
10. Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID: 33643049; PMCID: PMC7902932.
11. Li Y, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity. Biotechnol Appl Biochem. 2022 Dec;69(6):2530-2539. doi: 10.1002/bab.2302. Epub 2021 Dec 24. PMID: 34902878.
12. Mohamad Zobir SZ, Choi RJ, Modos D, Fan TP, Bender A. Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology. Synergy 11, Supplement, December 2020, 100073. https://doi.org/10.1016/j.synres.2021.100073
13. KalantarMotamedi Y, Choi RJ, Koh SB, Bramhall JL, Fan TP, Bender A. Prediction and identification of synergistic compound combinations against pancreatic cancer cells. iScience. 2021 Sep 3;24(9):103080. doi: 10.1016/j.isci.2021.103080. PMID: 34585118; PMCID: PMC8456050.
14. Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce (including Fan TP); Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. PMID: 33510482; PMCID: PMC7841765.
15. Deng H, Liang W, Fan TP, Zheng X, Cai Y. Modular engineering of Shiraia bambusicola for hypocrellin production through an efficient CRISPR system. Int J Biol Macromol. 2020 Dec 15;165(Pt A):796-803. doi:10.1016/j.ijbiomac.2020.09.208. Epub 2020 Sep 30. PMID: 33010268.
16. Liu J, Bai Y, Fan TP, Zheng X, Cai Y. Unveiling the Multipath Biosynthesis Mechanism of 2-Phenylethanol in Proteus mirabilis. JAgric Food Chem. 2020 Jul 22;68(29):7684-7690. doi: 10.1021/acs.jafc.0c02918. Epub 2020 Jul 10. PMID: 32608230.
17. Hu X, Bai Y, Fan TP, Zheng X, Cai Y. A novel type alanine dehydrogenase fromHelicobacter aurati: Molecular characterization and application. Int J Biol Macromol. 2020 Oct 15;161:636-642. doi: 10.1016/j.ijbiomac.2020.06.067. Epub 2020 Jun 10. PMID: 32534087.
18. Liang W, Xiong T, Wang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. A novel feruloyl esterase with high rosmarinic acid hydrolysis activity from Bacillus pumilus W3. Int J Biol Macromol. 2020 Oct 15;161:525-530. doi:10.1016/j.ijbiomac.2020.06.038. Epub 2020 Jun 9. PMID: 32531366.
19. Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Advanced strategy for metabolite exploration in filamentous fungi. Crit Rev Biotechnol. 2020 Mar;40(2):180-198. doi: 10.1080/07388551.2019.1709798. Epub 2020 Jan 6. PMID: 31906740.
20. Yan Y, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Production of rosmarinic acid with ATP and CoA double regenerating system. Enzyme Microb Technol. 2019 Dec;131:109392. doi: 10.1016/j.enzmictec.2019.109392. Epub 2019 Aug 5. PMID: 31615678.
21. Bai Y, He X, Bai Y, Sun Y, Zhao Z, Chen X, Li B, Xie J, Li Y, Jia P, Meng X, Zhao Y, Ding Y, Xiao C, Wang S, Yu J, Liao S, Zhang Y, Zhu Z, Zhang Q, Zhao Y, Qin F, Zhang Y, Wei X, Zeng M, Liang J, Cuan Y, Shan G, Fan TP, Wu B, Zheng X. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study. Eur J Med Chem. 2019 Dec 1;183:111650. doi: 10.1016/j.ejmech.2019.111650. Epub 2019 Sep 6. PMID: 31539780.
22. Iqbal M, Fan TP, Watson D, Alenezi S, Saleh K, Sahlan M. Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon. 2019 Jul 19;5(7):e01978. doi: 10.1016/j.heliyon.2019.e01978. PMID: 31372523; PMCID: PMC6656927.
23. Deng H, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. Expression and characterisation offeruloyl esterases from Lactobacillus fermentum JN248 and release offerulic acid from wheat bran. Int J Biol Macromol. 2019 Oct 1;138:272- 277. doi: 10.1016/j.ijbiomac.2019.07.086. Epub 2019 Jul 12. PMID: 31306699.
24. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Redox self-sufficient biocatalyst system for conversion of 3,4-Dihydroxyphenyl-L-alanine into (R)- or (S)- 3,4-Dihydroxyphenyllactic acid. J Ind Microbiol Biotechnol. 2019 Aug;46(8):1081-1090. doi: 10.1007/s10295-019-02200-7. Epub 2019 Jun 14. PMID: 31201648.
25. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Biosynthesis of D- danshensu from L-DOPA using engineered Escherichia coli whole cells. Appl Microbiol Biotechnol. 2019 Aug;103(15):6097-6105. doi: 10.1007/s00253-019- 09947-0. Epub 2019 Jun 11. PMID: 31187210.
26. Li C, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Efficient Synthesis of Hydroxytyrosol from l-3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole Cells. JAgric Food Chem. 2019 Jun 19;67(24):6867-6873. doi: 10.1021/acs.jafc.9b01856. Epub 2019 Jun 6. PMID: 31134807.
27. Xiong T, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. J Biotechnol. 2019 Jul 20;300:48-54. doi: 10.1016/j.jbiotec.2019.05.008. Epub 2019 May 21. PMID: 31125578.
28. Liao S, Han L, Zheng X, Wang X, Zhang P, Wu J, Liu R, Fu Y, Sun J, Kang X, Liu K, Fan TP, Li S, Zheng X. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019 Sep;176(17):3143-3160. doi: 10.1111/bph.14714. Epub 2019 Jul 9. Erratum in: Br J Pharmacol. 2021 Jul;178(14):2905. PMID: 31116880; PMCID: PMC6692590.
29. Sun Y, Bai Y, Zeng M, Chen X, Xie J, Li B, He X, Bai Y, Jia P, Meng X, Liang J, Wang S, Fan TP, Wu B, Zheng X. Pharmacokinetics and tissue distribution evaluation of α-asaronol and its main metabolite in rats by HPLC method. J Pharm Biomed Anal. 2019 Aug 5;172:349-356. doi: 10.1016/j.jpba.2019.05.004. Epub 2019 May 3. PMID: 31085397.
30. Yu F, Bai Y, Fan TP, Zheng X, Cai Y. Alcohol dehydrogenases from Proteus mirabilis contribute to alcoholic flavor. J Sci Food Agric. 2019 Jun;99(8):4123-4128. doi: 10.1002/jsfa.9642. Epub 2019 Mar 18. PMID: 30761541.
31. Wang YH, Bai YJ, Fan TP, Zheng XH, Cai YJ. Reducing 3,4-dihydroxyphenylpyruvic acid to d-3,4-dihydroxyphenyllactic acid via a coenzyme nonspecific d-lactate dehydrogenase from Lactobacillus reuteri. JAppl Microbiol. 2018 Aug 21. doi: 10.1111/jam.14077. Epub ahead of print. PMID: 30129993.
32. Liu J, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JAgric Food Chem. 2018 Apr 4;66(13):3498-3504. doi:10.1021/acs.jafc.8b00627. Epub 2018 Mar 23. PMID: 29560727.
33. He X, Bai Y, Zeng M, Zhao Z, Zhang Q, Xu N, Qin F, Wei X, Zhao M, Wu N, Li Z, Zhang Y, Fan TP, Zheng X. Anticonvulsant activities of α-asaronol ((E)-3'-hydroxyasarone), an active constituent derived from α-asarone. Pharmacol Rep. 2018 Feb;70(1):69-74. doi: 10.1016/j.pharep.2017.08.004. Epub 2017 Aug 31.PMID: 29331789.
34. Chen L, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a d-Lactate Dehydrogenase from Lactobacillus fermentum JN248 with High Phenylpyruvate Reductive Activity. J Food Sci. 2017 Oct;82(10):2269-2275. doi: 10.1111/1750- 3841.13863. Epub 2017 Sep 7. PMID: 28881036.
35. Chang FW, Fan HC, Liu JM, Fan TP, Jing J, Yang CL, Hsu RJ. Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors. Int J Mol Sci. 2017 Jan 14;18(1):163. doi: 10.3390/ijms18010163. PMID: 28098816; PMCID: PMC5297796.
36. Choi RJ, Roy A, Jung HJ, Ali MY, Min BS, Park CH, Yokozawa T, Fan TP, Choi JS, Jung HA. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J Ethnopharmacol. 2016 Aug 22;190:219-30. doi:10.1016/j.jep.2016. 06.013. Epub 2016 Jun 5. PMID: 27275774.
37. Mohamad Zobir SZ, Mohd Fauzi F, Liggi S, Drakakis G, Fu X, Fan TP*, Bender A. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evid Based Complement Alternat Med. 2016;2016:2106465. doi: 10.1155/2016/2106465. Epub 2016 Feb 18. PMID: 26989424; PMCID: PMC4775820.
38. Choi RJ, Wong AST, Jia W, Chang I-M, Wong RNS, Fan TP*, Kim YS (2015) Ginseng: A panacea linking East Asia and North America? Science 350 (6262 Suppl) S54-S56.
39. Schroen Y, Wang M, van Wietmarschen HA, Witkamp R, Hankemeier T, Fan TP, van der Greef J. (2015) Bridging the seen and the unseen: A systems pharmacology view of herbal medicine. Science 350 (6262 Suppl) S66-S69.
40. Jia W, Fan TP, Wang X, Xie G. (2015) The polypharmacokinetics of herbal medicine. Science 350 (6262 Suppl) S76-S78.
41. Yang XY, He K, Pan CS, Li Q, Liu YY, Yan L, Wei XH, Hu BH, Chang X, Mao XW, Huang DD, Wang LJ, Hu SW, Jiang Y, Wang GC, Fan JY, Fan TP, Han JY. 3, 4- dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury. Sci Rep. 2015 Jun 1;5:10739. doi: 10.1038/srep10739. PMID: 26030156; PMCID: PMC5377067.
42. Yin Q, Lu H, Bai Y, Tian A, Yang Q, Wu J, Yang C, Fan TP, Zhang Y, Zheng X, Zheng X, Li Z. A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. Br J Pharmacol. 2015 Dec;172(23):5573-85. doi: 10.1111/bph.13133. Epub 2015 May 5. PMID: 25766073; PMCID: PMC4667860.
43. Liu R, Runyon S, Wang Y, Oliver SG, Fan TP*, Zhang W (2015) Deciphering ancient combinatorial formulas: The Shexiang Baoxin pill. Science 347 (6219 Suppl) S40-S42.
44. Zhao, X, Zheng X, Fan, TP*, Li Z, Zhang Y, Zheng J* (2015) A novel drug discovery strategy inspired by traditional medicine philosophies. Science 347 (6219 Suppl) S38-S40.
20. Yan Y, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Production of rosmarinic acid with ATP and CoA double regenerating system. Enzyme Microb Technol. 2019 Dec;131:109392. doi: 10.1016/j.enzmictec.2019.109392. Epub 2019 Aug 5. PMID: 31615678.
21. Bai Y, He X, Bai Y, Sun Y, Zhao Z, Chen X, Li B, Xie J, Li Y, Jia P, Meng X, Zhao Y, Ding Y, Xiao C, Wang S, Yu J, Liao S, Zhang Y, Zhu Z, Zhang Q, Zhao Y, Qin F, Zhang Y, Wei X, Zeng M, Liang J, Cuan Y, Shan G, Fan TP, Wu B, Zheng X. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study. Eur J Med Chem. 2019 Dec 1;183:111650. doi: 10.1016/j.ejmech.2019.111650. Epub 2019 Sep 6. PMID: 31539780.
22. Iqbal M, Fan TP, Watson D, Alenezi S, Saleh K, Sahlan M. Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon. 2019 Jul 19;5(7):e01978. doi: 10.1016/j.heliyon.2019.e01978. PMID: 31372523; PMCID: PMC6656927.
23. Deng H, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. Expression and characterisation offeruloyl esterases from Lactobacillus fermentum JN248 and release offerulic acid from wheat bran. Int J Biol Macromol. 2019 Oct 1;138:272- 277. doi: 10.1016/j.ijbiomac.2019.07.086. Epub 2019 Jul 12. PMID: 31306699.
24. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Redox self-sufficient biocatalyst system for conversion of 3,4-Dihydroxyphenyl-L-alanine into (R)- or (S)- 3,4-Dihydroxyphenyllactic acid. J Ind Microbiol Biotechnol. 2019 Aug;46(8):1081-1090. doi: 10.1007/s10295-019-02200-7. Epub 2019 Jun 14. PMID: 31201648.
25. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Biosynthesis of D- danshensu from L-DOPA using engineered Escherichia coli whole cells. Appl Microbiol Biotechnol. 2019 Aug;103(15):6097-6105. doi: 10.1007/s00253-019- 09947-0. Epub 2019 Jun 11. PMID: 31187210.
26. Li C, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Efficient Synthesis of Hydroxytyrosol from l-3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole Cells. JAgric Food Chem. 2019 Jun 19;67(24):6867-6873. doi: 10.1021/acs.jafc.9b01856. Epub 2019 Jun 6. PMID: 31134807.
27. Xiong T, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. J Biotechnol. 2019 Jul 20;300:48-54. doi: 10.1016/j.jbiotec.2019.05.008. Epub 2019 May 21. PMID: 31125578.
28. Liao S, Han L, Zheng X, Wang X, Zhang P, Wu J, Liu R, Fu Y, Sun J, Kang X, Liu K, Fan TP, Li S, Zheng X. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019 Sep;176(17):3143-3160. doi: 10.1111/bph.14714. Epub 2019 Jul 9. Erratum in: Br J Pharmacol. 2021 Jul;178(14):2905. PMID: 31116880; PMCID: PMC6692590.
29. Sun Y, Bai Y, Zeng M, Chen X, Xie J, Li B, He X, Bai Y, Jia P, Meng X, Liang J, Wang S, Fan TP, Wu B, Zheng X. Pharmacokinetics and tissue distribution evaluation of α-asaronol and its main metabolite in rats by HPLC method. J Pharm Biomed Anal. 2019 Aug 5;172:349-356. doi: 10.1016/j.jpba.2019.05.004. Epub 2019 May 3. PMID: 31085397.
30. Yu F, Bai Y, Fan TP, Zheng X, Cai Y. Alcohol dehydrogenases from Proteus mirabilis contribute to alcoholic flavor. J Sci Food Agric. 2019 Jun;99(8):4123-4128. doi: 10.1002/jsfa.9642. Epub 2019 Mar 18. PMID: 30761541.
31. Wang YH, Bai YJ, Fan TP, Zheng XH, Cai YJ. Reducing 3,4-dihydroxyphenylpyruvic acid to d-3,4-dihydroxyphenyllactic acid via a coenzyme nonspecific d-lactate dehydrogenase from Lactobacillus reuteri. JAppl Microbiol. 2018 Aug 21. doi: 10.1111/jam.14077. Epub ahead of print. PMID: 30129993.
32. Liu J, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JAgric Food Chem. 2018 Apr 4;66(13):3498-3504. doi:10.1021/acs.jafc.8b00627. Epub 2018 Mar 23. PMID: 29560727.
33. He X, Bai Y, Zeng M, Zhao Z, Zhang Q, Xu N, Qin F, Wei X, Zhao M, Wu N, Li Z, Zhang Y, Fan TP, Zheng X. Anticonvulsant activities of α-asaronol ((E)-3'-hydroxyasarone), an active constituent derived from α-asarone. Pharmacol Rep. 2018 Feb;70(1):69-74. doi: 10.1016/j.pharep.2017.08.004. Epub 2017 Aug 31.PMID: 29331789.
34. Chen L, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a d-Lactate Dehydrogenase from Lactobacillus fermentum JN248 with High Phenylpyruvate Reductive Activity. J Food Sci. 2017 Oct;82(10):2269-2275. doi: 10.1111/1750- 3841.13863. Epub 2017 Sep 7. PMID: 28881036.
35. Chang FW, Fan HC, Liu JM, Fan TP, Jing J, Yang CL, Hsu RJ. Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors. Int J Mol Sci. 2017 Jan 14;18(1):163. doi: 10.3390/ijms18010163. PMID: 28098816; PMCID: PMC5297796.
36. Choi RJ, Roy A, Jung HJ, Ali MY, Min BS, Park CH, Yokozawa T, Fan TP, Choi JS, Jung HA. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J Ethnopharmacol. 2016 Aug 22;190:219-30. doi:10.1016/j.jep.2016. 06.013. Epub 2016 Jun 5. PMID: 27275774.
37. Mohamad Zobir SZ, Mohd Fauzi F, Liggi S, Drakakis G, Fu X, Fan TP*, Bender A. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evid Based Complement Alternat Med. 2016;2016:2106465. doi: 10.1155/2016/2106465. Epub 2016 Feb 18. PMID: 26989424; PMCID: PMC4775820.
38. Choi RJ, Wong AST, Jia W, Chang I-M, Wong RNS, Fan TP*, Kim YS (2015) Ginseng: A panacea linking East Asia and North America? Science 350 (6262 Suppl) S54-S56.
39. Schroen Y, Wang M, van Wietmarschen HA, Witkamp R, Hankemeier T, Fan TP, van der Greef J. (2015) Bridging the seen and the unseen: A systems pharmacology view of herbal medicine. Science 350 (6262 Suppl) S66-S69.
40. Jia W, Fan TP, Wang X, Xie G. (2015) The polypharmacokinetics of herbal medicine. Science 350 (6262 Suppl) S76-S78.
41. Yang XY, He K, Pan CS, Li Q, Liu YY, Yan L, Wei XH, Hu BH, Chang X, Mao XW, Huang DD, Wang LJ, Hu SW, Jiang Y, Wang GC, Fan JY, Fan TP, Han JY. 3, 4- dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury. Sci Rep. 2015 Jun 1;5:10739. doi: 10.1038/srep10739. PMID: 26030156; PMCID: PMC5377067.
42. Yin Q, Lu H, Bai Y, Tian A, Yang Q, Wu J, Yang C, Fan TP, Zhang Y, Zheng X, Zheng X, Li Z. A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. Br J Pharmacol. 2015 Dec;172(23):5573-85. doi: 10.1111/bph.13133. Epub 2015 May 5. PMID: 25766073; PMCID: PMC4667860.
43. Liu R, Runyon S, Wang Y, Oliver SG, Fan TP*, Zhang W (2015) Deciphering ancient combinatorial formulas: The Shexiang Baoxin pill. Science 347 (6219 Suppl) S40-S42.
44. Zhao, X, Zheng X, Fan, TP*, Li Z, Zhang Y, Zheng J* (2015) A novel drug discovery strategy inspired by traditional medicine philosophies. Science 347 (6219 Suppl) S38-S40.
45. Chen S*, Song J, Sun C, Xu J, Zhu Y, Verpoorte R, Fan TP*. (2015) Herbal genomics: Examining the biology of traditional medicines Science 347 (6219 Suppl) S27-S29.
46. Fan TP, Briggs J, Liu A, Liu L, Xu A (2014) Integrating traditional medicine into modern health care. Science 346 (6216 Suppl) S4.
47. Zhao X, Li Q, Xiao C, Zhang Y, Bian L, Zheng J, Zheng X, Li Z, Zhang Y, Fan TP* (2014) Oriented immobilisation of histidine-tagged protein and its application in exploring interactions between ligands and proteins. Analytical & Bioanalytical Chemistry 406: 2975-2985.
48. Chen CY, Chou KC, Adams JD, Fan TP, Litscher G. Recent novel high-tech researches in molecular biology. Biomed Res Int. 2015;2015:749160. doi: 10.1155/2015/749160. Epub 2015 Jan 28. PMID: 25695089; PMCID: PMC4324116.
49. Pelkonen O, Xu Q, Fan TP. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J Tradit Complement Med. 2014 Jan;4(1):1-7. doi: 10.4103/2225-4110.124323. PMID: 24872927; PMCID: PMC4032837.
50. Li Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, Liao Y, Pan R, Fan TP*. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014;2014:392324. doi: 10.1155/2014/392324. Epub 2014 Mar 12. PMID: 24744810; PMCID: PMC3972950.
51. Li S, Fan TP, Jia W, Lu A, Zhang W. Network pharmacology in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014;2014:138460. doi: 10.1155/2014/138460. Epub 2014 Feb 24. PMID: 24707305; PMCID: PMC3953584.
52. Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A.(2013) Linking Ayurveda and Western medicine by integrative analysis. J Ayurveda Integr Med. 4:117-9. doi: 10.4103/0975-9476.113882.
53. Xu Q, Bauer R, Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, Guo DA, Hylands PJ. The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med. 2013 Jun 13;13:132. doi: 10.1186/1472-6882-13-132. PMID: 23763836; PMCID: PMC3689083.
54. Mohd Fauzi F, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A. Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines. J Chem Inf Model. 2013 Mar 25;53(3):661-73. doi: 10.1021/ci3005513. Epub 2013 Feb 18. PMID: 23351136.
55. Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, Fan TP, Liu C. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963. doi: 10.1155/2012/284963. Epub 2012 Jul 29. PMID: 22927877; PMCID: PMC3424634.
56. Wei XH, Liu YY, Li Q, Yan L, Hu BH, Pan CS, Li ZX, Chang X, Fan JY, Zhao N, Sun K, Huang P, Wang CS, Fan TP, Han JY. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002. PMID: 22913380.
57. Yeh JC, Garrard IJ, Cho CW, Annie Bligh SW, Lu GH, Fan TP*, Fisher D. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. J ChromatogrA. 2012 May 4;1236:132-8. doi: 10.1016/j.chroma.2012.03.013. Epub 2012 Mar 9. PMID: 22458966.
58. Uzuner H, Bauer R, Fan TP, Guo DA, Dias A, El-Nezami H, Efferth T, Williamson EM, Heinrich M, Robinson N, Hylands PJ, Hendry BM, Cheng YC, Xu Q. Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. J Ethnopharmacol. 2012 Apr 10;140(3):458-68. doi: 10.1016/j.jep.2012.02.028. Epub 2012 Feb 23. PMID: 22387462.
59. Fan TP*, Deal G, Koo HL, Rees D, Sun H, Chen S, Dou JH, Makarov VG, Pozharitskaya ON, Shikov AN, Kim YS, Huang YT, Chang YS, Jia W, Dias A, Wong VC, Chan K. Future development of global regulations of Chinese herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):568-86. doi:10.1016/j.jep.2012.02.029. Epub 2012 Feb 25. PMID: 22373513.
60. Pelkonen O, Pasanen M, Lindon JC, Chan K, Zhao L, Deal G, Xu Q, Fan TP. Omics and its potential impact on R&D and regulation of complex herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):587-93. doi: 10.1016/j.jep.2012.01.035. Epub 2012 Feb 1. PMID: 22313626.
61. Xu SP, Yang YY, Xue D, Liu JX, Liu XM, Fan TP, le Pan R, Li P. Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice. Evid Based Complement Alternat Med. 2011;2011:839720. doi:10.1155/2011/839720. Epub 2011 Mar 6. PMID: 21423642; PMCID: PMC3057668.
62. Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP*. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15. PMID: 21327473.
63. Uzuner H, Fan TP, Dias A, Guo DA, El-Nezami HS, Xu Q. Establishing an EU-China consortium on traditional Chinese medicine research. Chin Med. 2010 Dec 14;5:42. doi: 10.1186/1749-8546-5-42. PMID: 21156056; PMCID: PMC3019128.
64. Lee YM, Ting CM, Cheng YK, Fan TP, Wong RN, Lung ML, Mak NK. Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells. Cancer Lett. 2008 Sep 18;268(2):295-307. doi: 10.1016/j.canlet.2008.04.010. Epub 2008 May 19. PMID: 18492602.
65. Li P, Xu G, Li SP, Wang YT, Fan TP, Zhao QS, Zhang QW. Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. JAgric Food Chem. 2008 Feb 27;56(4):1164-71. doi: 10.1021/jf073020u. Epub 2008 Jan 17. PMID: 18198831.
66. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2008 Jan 11;365(2):285-90. doi: 10.1016/j.bbrc.2007.10.166. Epub 2007 Nov 5. PMID: 17986384.
67. Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran- Tink J, Wong AS. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007 Sep;152(2):207-15. doi: 10.1038/sj.bjp.0707359. Epub 2007 Jul 2. Erratum in: Br J Pharmacol. 2020 Jan;177(1):236. PMID: 17603552; PMCID: PMC1978254.
68. Bapna A, Federici L, Venter H, Velamakanni S, Luisi B, Fan TP, van Veen HW. Two proton translocation pathways in a secondary active multidrug transporter. J Mol Microbiol Biotechnol. 2007;12(3-4):197-209. doi: 10.1159/000099641. PMID: 17587868.
69. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan TP, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007 May 15;2:6. doi: 10.1186/1749-8546-2-6. PMID: 17502003; PMCID: PMC1876803.
70. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, NgTB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007;14(12):1371-80. doi: 10.2174/092986707780597916. PMID: 17504218.
71. Lim MW, Fan TP. A "pancreatic tooth" design best accommodates the limitations of current artificial pancreas technology. Med Hypotheses. 2007;69(4):741-5. doi: 10.1016/j.mehy.2006.08.047. Epub 2007 Mar 30. PMID: 17399910.
72. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007 Mar;52(3):827-35. doi:10.1016/j.neuropharm.2006.10. 001. Epub 2006 Nov 22. PMID: 17123556.
73. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45. doi: 10.1016/j.bcp.2006.04.034. Epub 2006 May 12. PMID: 16793023.
74. Jin J, Shahi S, Kang HK, van Veen HW, Fan TP*. Metabolites of ginsenosides as novel BCRP inhibitors. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1308-14. doi: 10.1016/j.bbrc.2006.04.152. Epub 2006 May 4. PMID: 16729968.
75. Fan TP*, Yeh JC, Leung KW, Yue PY, Wong RN. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006 Jun;27(6):297-309. doi: 10.1016/j.tips.2006.04.006. Epub 2006 May 11. PMID: 16697473.
76. Leung KW, Cheng YK, Mak NK, Chan KK, Fan TP, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett. 2006 May 29;580(13):3211-6. doi: 10.1016/j.febslet.2006.04.080. Epub 2006 May 4. PMID: 16696977.
77. Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis. 2005;8(3):205-16. doi: 10.1007/s10456-005-9000-2. Epub 2005 Nov 22. Erratum in: Angiogenesis. 2007;10(1):69. PMID: 16328162.
78. Kok TW, Yue PY, Mak NK, Fan TP, Liu L, Wong RN. The anti-angiogenic effect of sinomenine. Angiogenesis. 2005;8(1):3-12. doi: 10.1007/s10456-005-2892-z. PMID: 16132613.
79. Sengupta S, Sellers LA, Gherardi E, Sasisekharan R, Fan TP*. Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesis. Angiogenesis. 2004;7(4):285-94. doi: 10.1007/s10456-004-5238-3. Epub 2005 May 9. PMID: 15886872.
80. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R, Fan TP*. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004 Sep 7;110(10):1219-25. doi: 10.1161/01.CIR.0000140676.88412.CF. Epub 2004 Aug 30. PMID: 15337705.
81. Bevan D, Gherardi E, Fan TP, Edwards D, Warn R. Diverse and potent activities of HGF/SF in skin wound repair. J Pathol. 2004 Jul;203(3):831-8. doi: 10.1002/path.1578. PMID: 15221943.
82. van Beijnum JR, Fan TP, Griffioen AW. Eur(omega)conference Angiogenesis II. Angiogenesis. 2003;6(3):159-64. doi: 10.1023/b:agen.0000021513.95526.cb. PMID: 15129652.
83. Bapna A, Vickerstaffe E, Warrington BH, Ladlow M, Fan TP, Ley SV. Polymer- assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors. Org Biomol Chem. 2004 Feb 21;2(4):611-20. doi: 10.1039/b313414h. Epub 2004 Jan 27. PMID: 14770241.
84. Sengupta S, Sellers LA, Cindrova T, Skepper J, Gherardi E, Sasisekharan R, Fan TP*. Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res. 2003 Dec 1;63(23):8351-9. PMID: 14678996.
85. Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003 Jun;88(6):2889-99. doi: 10.1210/jc.2002-021912. PMID: 12788903.
86. Sengupta S, Sellers LA, Li RC, Gherardi E, Zhao G, Watson N, Sasisekharan R, Fan TP*. Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis. Circulation. 2003 Jun 17;107(23):2955-61. doi: 10.1161/01.CIR.0000077501. 19266.E5. Epub 2003 Jun 2. PMID: 12782568.
87. Sengupta S, Sellers LA, Matheson HB, Fan TP*. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol. 2003 May;139(2):219-31. doi: 10.1038/sj.bjp.0705216. PMID: 12770927; PMCID: PMC1573835.
88. Sengupta S, Gherardi E, Sellers LA, Wood JM, Sasisekharan R, Fan TP*. Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):69-75. doi: 10.1161/01.atv.0000048701.86621.d0. PMID: 12524227.
89. Alderton F, Fan TP, Humphrey PP. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001 Feb;132(3):760-6. doi: 10.1038/sj.bjp.0703862. PMID: 11159729; PMCID: PMC1572604.
90. Boyle JJ, Wilson B, Bicknell R, Harrower S, Weissberg PL, Fan TP. Expression of angiogenic factor thymidine phosphorylase and angiogenesis in human atherosclerosis. J Pathol. 2000 Oct;192(2):234-42. doi: 10.1002/1096- 9896(2000)9999:9999<::AID-PATH699>3.0.CO;2-9. PMID: 11004701.
91. Griffioen AW, Fan TP. Merger of Angiogenesis and Angiogenesis Research-heading for a quality journal. Angiogenesis. 1998;2(3):201-2. doi: 10.1023/A:1009289303145. PMID: 14517460.
92. Lauder H, Frost EE, Hiley CR, Fan TP*. Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Angiogenesis. 1998;2(1):67-80. doi: 10.1023/a:1009006527462. PMID: 14517377.
93. Alderton F, Fan TP, Schindler M, Humphrey PP. Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation. Br J Pharmacol. 1998 Dec;125(8):1630-3. doi: 10.1038/sj.bjp.0702282. PMID: 9886753; PMCID: PMC1565767.
94. Alderton F, Lauder H, Feniuk W, Fan TP, Humphrey PP. Differential effects of somatostatin and angiopeptin on cell proliferation. Br J Pharmacol. 1998 May;124(2):323-30. doi: 10.1038/sj.bjp.0701843. PMID: 9641549; PMCID: PMC1565396.
95. Lauder H, Sellers LA, Fan TP, Feniuk W, Humphrey PP. Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. Br J Pharmacol. 1997 Oct;122(4):663-70. doi: 10.1038/sj.bjp.0701443. PMID: 9375962; PMCID: PMC1564995.
96. Walsh DA, Hu DE, Wharton J, Catravas JD, Blake DR, Fan TP*. Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Br J Pharmacol. 1997 Apr;120(7):1302-11. doi: 10.1038/sj.bjp.0701062. PMID: 9105706; PMCID: PMC1564611.
97. Walsh DA, Hu DE, Mapp PI, Polak JM, Blake DR, Fan TP*. Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma. Histochem J. 1996 Nov;28(11):759-69. doi: 10.1007/BF02272149. PMID: 8968728.
98. Hori Y, Hu DE, Yasui K, Smither RL, Gresham GA, Fan TP*. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Br J Pharmacol. 1996 Aug;118(7):1584-91. doi: 10.1111/j.1476- 5381.1996.tb15578.x. PMID: 8842418; PMCID: PMC1909851.
99. Hu DE, Hiley CR, Fan TP*. Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model. Br J Pharmacol. 1996 Feb;117(3):545-551. doi: 10.1111/j.1476- 5381.1996.tb15225.x. PMID: 8821547; PMCID: PMC1909324.
100. Lees VC, Fan TP, West DC. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest. 1995 Aug;73(2):259-66. PMID: 7543630.
101. Michel AD, Chau NM, Fan TP, Frost EE, Humphrey PP. Evidence that [3H]-alpha,beta-methylene ATP may label an endothelial-derived cell line 5'-nucleotidase with high affinity. Br J Pharmacol. 1995 Jul;115(5):767-74. doi: 10.1111/j.1476-5381.1995.tb14999.x. PMID: 8548175; PMCID: PMC1908513.
102. Hu DE, Hiley CR, Smither RL, Gresham GA, Fan TP*. Correlation of 133Xe clearance, blood flow and histology in the rat sponge model for angiogenesis. Further studies with angiogenic modifiers. Lab Invest. 1995 May;72(5):601-10. PMID: 7538184.
103. Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA. 1995 Feb 14;92(4):998-1002. doi:10.1073/pnas.92.4.998. PMID: 7532308; PMCID: PMC42624.
104. Fan TP*, Jaggar R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci. 1995 Feb;16(2):57-66. doi: 10.1016/s0165-6147(00)88979-8. PMID: 7539171.
105. Hu DE, Fan TP*. Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat. Inflammation. 1995 Feb;19(1):39-54. doi:10.1007/BF01534379. PMID: 7535750.
106. Hu DE, Fan TP*. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. doi: 10.1111/j.1476-5381.1995.tb13221.x. PMID: 7533611; PMCID: PMC1510224.
107. Lees VC, Fan TP. A freeze-injured skin graft model for the quantitative study of basic fibroblast growth factor and other promoters ofangiogenesis in wound healing. Br J Plast Surg. 1994 Jul;47(5):349-59. doi: 10.1016/0007- 1226(94)90095-7. PMID: 7522103.
108. Braddock PS, Hu DE, Fan TP, Stratford IJ, Harris AL, Bicknell R. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer. 1994 May;69(5):890-8. doi: 10.1038/bjc.1994.172. PMID: 7514028; PMCID: PMC1968907.
109. Hu DE, Hori Y, Presta M, Gresham GA, Fan TP*. Inhibition of angiogenesis in rats by IL-1 receptor antagonist and selected cytokine antibodies. Inflammation. 1994 Feb;18(1):45-58. doi: 10.1007/BF01534597. PMID: 7515856.
110. Fan TP*. Angiosuppressive therapy for cancer. Trends Pharmacol Sci. 1994 Feb;15(2):33-6. doi: 10.1016/0165-6147(94)90103-1. PMID: 7513100.
111. Wren AD, Hiley CR, Fan TP*. Endothelin-3 mediated proliferation in wounded human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1993 Oct 15;196(1):369-75. doi: 10.1006/bbrc.1993.2258. PMID: 8216314.
112. Fan TP*, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. doi: 10.1111/j.1476-5381.1993.tb13769.x. PMID: 7693287; PMCID: PMC2176009.
113. Hu DE, Fan TP*. [Leu8]des-Arg9-bradykinin inhibits the angiogenic effect of bradykinin and interleukin-1 in rats. Br J Pharmacol. 1993 May;109(1):14-7. doi:10.1111/j.1476-5381.1993.tb13525.x. PMID: 7684297; PMCID: PMC2175594.
114. Hu DE, Hori Y, Fan TP*. Interleukin-8 stimulates angiogenesis in rats. Inflammation. 1993 Apr;17(2):135-43. doi: 10.1007/BF00916100. PMID: 7684027.
115. Fan TP*, Frost EE, Wren AD. A multichannel wounding device for the study of vascular repair in vitro. EXS. 1992; 61:315-20. doi: 10.1007/978-3-0348-7001-6_50. PMID: 1377550.
116. Fan TP*, Hu DE, Smither RL, Gresham GA. Further studies on angiogenesis in a rat sponge model. EXS. 1992; 61:308-14. doi: 10.1007/978-3-0348-7001-6_ 49. PMID: 1377549.
117. Smither RL, Fan TP*. Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. EXS. 1992; 61:230-4. doi: 10.1007/978-3-0348-7001- 6_35. PMID: 1319778.
118. Dinh Xuan AT, Fan TP, Higenbottam TW, Wallwork J. Cyclosporine in vitro reduces endothelium-dependent relaxation to acetylcholine but does not affect relaxation to nitrovasodilators. Transplant Proc. 1990 Aug;22(4):1723-5. PMID: 2389442.
119. Andrade SP, Fan TP, Lewis GP. Quantitative in-vivo studies on angiogenesis in a rat sponge model. Br J Exp Pathol. 1987 Dec;68(6):755-66. PMID: 2447929;
PMCID: PMC2013085.
120. Lo WW, Fan TP*. Histamine stimulates inositol phosphate accumulation via the H1-receptor in cultured human endothelial cells. Biochem Biophys Res Commun. 1987 Oct 14;148(1):47-53. doi: 10.1016/0006-291x(87)91074-6. PMID: 3675593.
121. Fan TP*, Cox JH, Chisholm PM. Mechanism of action of cyclosporine in preventing cardiac allograft rejection. II. Graft tissue levels of prostacyclin and thromboxane. Transplantation. 1987 Mar;43(3):343-5. doi: 10.1097/00007890- 198703000-00004. PMID: 3547787.
122. Cole OF, Fan TP, Lewis GP. Release of eicosanoids from cultured rat aortic endothelial cells; studies with arachidonic acid and calcium ionophore A23187. Cell Biol Int Rep. 1986 Jun;10(6):407-13. doi: 10.1016/0309-1651(86)90035-4. PMID: 3091278.
123. Cole OF, Fan TP, Lewis GP. Isolation, characterisation, growth and culture of endothelial cells from the rat aorta. Cell Biol Int Rep. 1986 Jun;10(6):399-405. doi: 10.1016/0309-1651(86)90034-2. PMID: 3017582.
124. Fan TP*, Lewis GP. Mechanism of cyclosporin A-induced inhibition of prostacyclin synthesis by macrophages. Prostaglandins. 1985 Nov;30(5):735-47. doi:10.1016/0090-6980(85)90004-8. PMID: 3936119.
125. Fan TP*, Lewis GP. Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts. Br J Pharmacol. 1984 Feb;81(2):361-71. doi: 10.1111/j.1476-5381.1984. tb10087.x.PMID: 6423022; PMCID: PMC1986882.
126. Fan TP*, Lewis GP. Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A. Br J Pharmacol. 1982 Jul;76(3):491-7. doi: 10.1111/j.1476-5381.1982.tb09244.x. PMID: 7049288; PMCID: PMC2071795.
46. Fan TP, Briggs J, Liu A, Liu L, Xu A (2014) Integrating traditional medicine into modern health care. Science 346 (6216 Suppl) S4.
47. Zhao X, Li Q, Xiao C, Zhang Y, Bian L, Zheng J, Zheng X, Li Z, Zhang Y, Fan TP* (2014) Oriented immobilisation of histidine-tagged protein and its application in exploring interactions between ligands and proteins. Analytical & Bioanalytical Chemistry 406: 2975-2985.
48. Chen CY, Chou KC, Adams JD, Fan TP, Litscher G. Recent novel high-tech researches in molecular biology. Biomed Res Int. 2015;2015:749160. doi: 10.1155/2015/749160. Epub 2015 Jan 28. PMID: 25695089; PMCID: PMC4324116.
49. Pelkonen O, Xu Q, Fan TP. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J Tradit Complement Med. 2014 Jan;4(1):1-7. doi: 10.4103/2225-4110.124323. PMID: 24872927; PMCID: PMC4032837.
50. Li Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, Liao Y, Pan R, Fan TP*. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014;2014:392324. doi: 10.1155/2014/392324. Epub 2014 Mar 12. PMID: 24744810; PMCID: PMC3972950.
51. Li S, Fan TP, Jia W, Lu A, Zhang W. Network pharmacology in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014;2014:138460. doi: 10.1155/2014/138460. Epub 2014 Feb 24. PMID: 24707305; PMCID: PMC3953584.
52. Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A.(2013) Linking Ayurveda and Western medicine by integrative analysis. J Ayurveda Integr Med. 4:117-9. doi: 10.4103/0975-9476.113882.
53. Xu Q, Bauer R, Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, Guo DA, Hylands PJ. The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med. 2013 Jun 13;13:132. doi: 10.1186/1472-6882-13-132. PMID: 23763836; PMCID: PMC3689083.
54. Mohd Fauzi F, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A. Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines. J Chem Inf Model. 2013 Mar 25;53(3):661-73. doi: 10.1021/ci3005513. Epub 2013 Feb 18. PMID: 23351136.
55. Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, Fan TP, Liu C. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963. doi: 10.1155/2012/284963. Epub 2012 Jul 29. PMID: 22927877; PMCID: PMC3424634.
56. Wei XH, Liu YY, Li Q, Yan L, Hu BH, Pan CS, Li ZX, Chang X, Fan JY, Zhao N, Sun K, Huang P, Wang CS, Fan TP, Han JY. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002. PMID: 22913380.
57. Yeh JC, Garrard IJ, Cho CW, Annie Bligh SW, Lu GH, Fan TP*, Fisher D. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. J ChromatogrA. 2012 May 4;1236:132-8. doi: 10.1016/j.chroma.2012.03.013. Epub 2012 Mar 9. PMID: 22458966.
58. Uzuner H, Bauer R, Fan TP, Guo DA, Dias A, El-Nezami H, Efferth T, Williamson EM, Heinrich M, Robinson N, Hylands PJ, Hendry BM, Cheng YC, Xu Q. Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. J Ethnopharmacol. 2012 Apr 10;140(3):458-68. doi: 10.1016/j.jep.2012.02.028. Epub 2012 Feb 23. PMID: 22387462.
59. Fan TP*, Deal G, Koo HL, Rees D, Sun H, Chen S, Dou JH, Makarov VG, Pozharitskaya ON, Shikov AN, Kim YS, Huang YT, Chang YS, Jia W, Dias A, Wong VC, Chan K. Future development of global regulations of Chinese herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):568-86. doi:10.1016/j.jep.2012.02.029. Epub 2012 Feb 25. PMID: 22373513.
60. Pelkonen O, Pasanen M, Lindon JC, Chan K, Zhao L, Deal G, Xu Q, Fan TP. Omics and its potential impact on R&D and regulation of complex herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):587-93. doi: 10.1016/j.jep.2012.01.035. Epub 2012 Feb 1. PMID: 22313626.
61. Xu SP, Yang YY, Xue D, Liu JX, Liu XM, Fan TP, le Pan R, Li P. Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice. Evid Based Complement Alternat Med. 2011;2011:839720. doi:10.1155/2011/839720. Epub 2011 Mar 6. PMID: 21423642; PMCID: PMC3057668.
62. Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP*. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15. PMID: 21327473.
63. Uzuner H, Fan TP, Dias A, Guo DA, El-Nezami HS, Xu Q. Establishing an EU-China consortium on traditional Chinese medicine research. Chin Med. 2010 Dec 14;5:42. doi: 10.1186/1749-8546-5-42. PMID: 21156056; PMCID: PMC3019128.
64. Lee YM, Ting CM, Cheng YK, Fan TP, Wong RN, Lung ML, Mak NK. Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells. Cancer Lett. 2008 Sep 18;268(2):295-307. doi: 10.1016/j.canlet.2008.04.010. Epub 2008 May 19. PMID: 18492602.
65. Li P, Xu G, Li SP, Wang YT, Fan TP, Zhao QS, Zhang QW. Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. JAgric Food Chem. 2008 Feb 27;56(4):1164-71. doi: 10.1021/jf073020u. Epub 2008 Jan 17. PMID: 18198831.
66. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2008 Jan 11;365(2):285-90. doi: 10.1016/j.bbrc.2007.10.166. Epub 2007 Nov 5. PMID: 17986384.
67. Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran- Tink J, Wong AS. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007 Sep;152(2):207-15. doi: 10.1038/sj.bjp.0707359. Epub 2007 Jul 2. Erratum in: Br J Pharmacol. 2020 Jan;177(1):236. PMID: 17603552; PMCID: PMC1978254.
68. Bapna A, Federici L, Venter H, Velamakanni S, Luisi B, Fan TP, van Veen HW. Two proton translocation pathways in a secondary active multidrug transporter. J Mol Microbiol Biotechnol. 2007;12(3-4):197-209. doi: 10.1159/000099641. PMID: 17587868.
69. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan TP, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007 May 15;2:6. doi: 10.1186/1749-8546-2-6. PMID: 17502003; PMCID: PMC1876803.
70. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, NgTB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007;14(12):1371-80. doi: 10.2174/092986707780597916. PMID: 17504218.
71. Lim MW, Fan TP. A "pancreatic tooth" design best accommodates the limitations of current artificial pancreas technology. Med Hypotheses. 2007;69(4):741-5. doi: 10.1016/j.mehy.2006.08.047. Epub 2007 Mar 30. PMID: 17399910.
72. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007 Mar;52(3):827-35. doi:10.1016/j.neuropharm.2006.10. 001. Epub 2006 Nov 22. PMID: 17123556.
73. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45. doi: 10.1016/j.bcp.2006.04.034. Epub 2006 May 12. PMID: 16793023.
74. Jin J, Shahi S, Kang HK, van Veen HW, Fan TP*. Metabolites of ginsenosides as novel BCRP inhibitors. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1308-14. doi: 10.1016/j.bbrc.2006.04.152. Epub 2006 May 4. PMID: 16729968.
75. Fan TP*, Yeh JC, Leung KW, Yue PY, Wong RN. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006 Jun;27(6):297-309. doi: 10.1016/j.tips.2006.04.006. Epub 2006 May 11. PMID: 16697473.
76. Leung KW, Cheng YK, Mak NK, Chan KK, Fan TP, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett. 2006 May 29;580(13):3211-6. doi: 10.1016/j.febslet.2006.04.080. Epub 2006 May 4. PMID: 16696977.
77. Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis. 2005;8(3):205-16. doi: 10.1007/s10456-005-9000-2. Epub 2005 Nov 22. Erratum in: Angiogenesis. 2007;10(1):69. PMID: 16328162.
78. Kok TW, Yue PY, Mak NK, Fan TP, Liu L, Wong RN. The anti-angiogenic effect of sinomenine. Angiogenesis. 2005;8(1):3-12. doi: 10.1007/s10456-005-2892-z. PMID: 16132613.
79. Sengupta S, Sellers LA, Gherardi E, Sasisekharan R, Fan TP*. Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesis. Angiogenesis. 2004;7(4):285-94. doi: 10.1007/s10456-004-5238-3. Epub 2005 May 9. PMID: 15886872.
80. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R, Fan TP*. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004 Sep 7;110(10):1219-25. doi: 10.1161/01.CIR.0000140676.88412.CF. Epub 2004 Aug 30. PMID: 15337705.
81. Bevan D, Gherardi E, Fan TP, Edwards D, Warn R. Diverse and potent activities of HGF/SF in skin wound repair. J Pathol. 2004 Jul;203(3):831-8. doi: 10.1002/path.1578. PMID: 15221943.
82. van Beijnum JR, Fan TP, Griffioen AW. Eur(omega)conference Angiogenesis II. Angiogenesis. 2003;6(3):159-64. doi: 10.1023/b:agen.0000021513.95526.cb. PMID: 15129652.
83. Bapna A, Vickerstaffe E, Warrington BH, Ladlow M, Fan TP, Ley SV. Polymer- assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors. Org Biomol Chem. 2004 Feb 21;2(4):611-20. doi: 10.1039/b313414h. Epub 2004 Jan 27. PMID: 14770241.
84. Sengupta S, Sellers LA, Cindrova T, Skepper J, Gherardi E, Sasisekharan R, Fan TP*. Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res. 2003 Dec 1;63(23):8351-9. PMID: 14678996.
85. Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003 Jun;88(6):2889-99. doi: 10.1210/jc.2002-021912. PMID: 12788903.
86. Sengupta S, Sellers LA, Li RC, Gherardi E, Zhao G, Watson N, Sasisekharan R, Fan TP*. Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis. Circulation. 2003 Jun 17;107(23):2955-61. doi: 10.1161/01.CIR.0000077501. 19266.E5. Epub 2003 Jun 2. PMID: 12782568.
87. Sengupta S, Sellers LA, Matheson HB, Fan TP*. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol. 2003 May;139(2):219-31. doi: 10.1038/sj.bjp.0705216. PMID: 12770927; PMCID: PMC1573835.
88. Sengupta S, Gherardi E, Sellers LA, Wood JM, Sasisekharan R, Fan TP*. Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):69-75. doi: 10.1161/01.atv.0000048701.86621.d0. PMID: 12524227.
89. Alderton F, Fan TP, Humphrey PP. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001 Feb;132(3):760-6. doi: 10.1038/sj.bjp.0703862. PMID: 11159729; PMCID: PMC1572604.
90. Boyle JJ, Wilson B, Bicknell R, Harrower S, Weissberg PL, Fan TP. Expression of angiogenic factor thymidine phosphorylase and angiogenesis in human atherosclerosis. J Pathol. 2000 Oct;192(2):234-42. doi: 10.1002/1096- 9896(2000)9999:9999<::AID-PATH699>3.0.CO;2-9. PMID: 11004701.
91. Griffioen AW, Fan TP. Merger of Angiogenesis and Angiogenesis Research-heading for a quality journal. Angiogenesis. 1998;2(3):201-2. doi: 10.1023/A:1009289303145. PMID: 14517460.
92. Lauder H, Frost EE, Hiley CR, Fan TP*. Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Angiogenesis. 1998;2(1):67-80. doi: 10.1023/a:1009006527462. PMID: 14517377.
93. Alderton F, Fan TP, Schindler M, Humphrey PP. Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation. Br J Pharmacol. 1998 Dec;125(8):1630-3. doi: 10.1038/sj.bjp.0702282. PMID: 9886753; PMCID: PMC1565767.
94. Alderton F, Lauder H, Feniuk W, Fan TP, Humphrey PP. Differential effects of somatostatin and angiopeptin on cell proliferation. Br J Pharmacol. 1998 May;124(2):323-30. doi: 10.1038/sj.bjp.0701843. PMID: 9641549; PMCID: PMC1565396.
95. Lauder H, Sellers LA, Fan TP, Feniuk W, Humphrey PP. Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. Br J Pharmacol. 1997 Oct;122(4):663-70. doi: 10.1038/sj.bjp.0701443. PMID: 9375962; PMCID: PMC1564995.
96. Walsh DA, Hu DE, Wharton J, Catravas JD, Blake DR, Fan TP*. Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Br J Pharmacol. 1997 Apr;120(7):1302-11. doi: 10.1038/sj.bjp.0701062. PMID: 9105706; PMCID: PMC1564611.
97. Walsh DA, Hu DE, Mapp PI, Polak JM, Blake DR, Fan TP*. Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma. Histochem J. 1996 Nov;28(11):759-69. doi: 10.1007/BF02272149. PMID: 8968728.
98. Hori Y, Hu DE, Yasui K, Smither RL, Gresham GA, Fan TP*. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Br J Pharmacol. 1996 Aug;118(7):1584-91. doi: 10.1111/j.1476- 5381.1996.tb15578.x. PMID: 8842418; PMCID: PMC1909851.
99. Hu DE, Hiley CR, Fan TP*. Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model. Br J Pharmacol. 1996 Feb;117(3):545-551. doi: 10.1111/j.1476- 5381.1996.tb15225.x. PMID: 8821547; PMCID: PMC1909324.
100. Lees VC, Fan TP, West DC. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest. 1995 Aug;73(2):259-66. PMID: 7543630.
101. Michel AD, Chau NM, Fan TP, Frost EE, Humphrey PP. Evidence that [3H]-alpha,beta-methylene ATP may label an endothelial-derived cell line 5'-nucleotidase with high affinity. Br J Pharmacol. 1995 Jul;115(5):767-74. doi: 10.1111/j.1476-5381.1995.tb14999.x. PMID: 8548175; PMCID: PMC1908513.
102. Hu DE, Hiley CR, Smither RL, Gresham GA, Fan TP*. Correlation of 133Xe clearance, blood flow and histology in the rat sponge model for angiogenesis. Further studies with angiogenic modifiers. Lab Invest. 1995 May;72(5):601-10. PMID: 7538184.
103. Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA. 1995 Feb 14;92(4):998-1002. doi:10.1073/pnas.92.4.998. PMID: 7532308; PMCID: PMC42624.
104. Fan TP*, Jaggar R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci. 1995 Feb;16(2):57-66. doi: 10.1016/s0165-6147(00)88979-8. PMID: 7539171.
105. Hu DE, Fan TP*. Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat. Inflammation. 1995 Feb;19(1):39-54. doi:10.1007/BF01534379. PMID: 7535750.
106. Hu DE, Fan TP*. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. doi: 10.1111/j.1476-5381.1995.tb13221.x. PMID: 7533611; PMCID: PMC1510224.
107. Lees VC, Fan TP. A freeze-injured skin graft model for the quantitative study of basic fibroblast growth factor and other promoters ofangiogenesis in wound healing. Br J Plast Surg. 1994 Jul;47(5):349-59. doi: 10.1016/0007- 1226(94)90095-7. PMID: 7522103.
108. Braddock PS, Hu DE, Fan TP, Stratford IJ, Harris AL, Bicknell R. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer. 1994 May;69(5):890-8. doi: 10.1038/bjc.1994.172. PMID: 7514028; PMCID: PMC1968907.
109. Hu DE, Hori Y, Presta M, Gresham GA, Fan TP*. Inhibition of angiogenesis in rats by IL-1 receptor antagonist and selected cytokine antibodies. Inflammation. 1994 Feb;18(1):45-58. doi: 10.1007/BF01534597. PMID: 7515856.
110. Fan TP*. Angiosuppressive therapy for cancer. Trends Pharmacol Sci. 1994 Feb;15(2):33-6. doi: 10.1016/0165-6147(94)90103-1. PMID: 7513100.
111. Wren AD, Hiley CR, Fan TP*. Endothelin-3 mediated proliferation in wounded human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1993 Oct 15;196(1):369-75. doi: 10.1006/bbrc.1993.2258. PMID: 8216314.
112. Fan TP*, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. doi: 10.1111/j.1476-5381.1993.tb13769.x. PMID: 7693287; PMCID: PMC2176009.
113. Hu DE, Fan TP*. [Leu8]des-Arg9-bradykinin inhibits the angiogenic effect of bradykinin and interleukin-1 in rats. Br J Pharmacol. 1993 May;109(1):14-7. doi:10.1111/j.1476-5381.1993.tb13525.x. PMID: 7684297; PMCID: PMC2175594.
114. Hu DE, Hori Y, Fan TP*. Interleukin-8 stimulates angiogenesis in rats. Inflammation. 1993 Apr;17(2):135-43. doi: 10.1007/BF00916100. PMID: 7684027.
115. Fan TP*, Frost EE, Wren AD. A multichannel wounding device for the study of vascular repair in vitro. EXS. 1992; 61:315-20. doi: 10.1007/978-3-0348-7001-6_50. PMID: 1377550.
116. Fan TP*, Hu DE, Smither RL, Gresham GA. Further studies on angiogenesis in a rat sponge model. EXS. 1992; 61:308-14. doi: 10.1007/978-3-0348-7001-6_ 49. PMID: 1377549.
117. Smither RL, Fan TP*. Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. EXS. 1992; 61:230-4. doi: 10.1007/978-3-0348-7001- 6_35. PMID: 1319778.
118. Dinh Xuan AT, Fan TP, Higenbottam TW, Wallwork J. Cyclosporine in vitro reduces endothelium-dependent relaxation to acetylcholine but does not affect relaxation to nitrovasodilators. Transplant Proc. 1990 Aug;22(4):1723-5. PMID: 2389442.
119. Andrade SP, Fan TP, Lewis GP. Quantitative in-vivo studies on angiogenesis in a rat sponge model. Br J Exp Pathol. 1987 Dec;68(6):755-66. PMID: 2447929;
PMCID: PMC2013085.
120. Lo WW, Fan TP*. Histamine stimulates inositol phosphate accumulation via the H1-receptor in cultured human endothelial cells. Biochem Biophys Res Commun. 1987 Oct 14;148(1):47-53. doi: 10.1016/0006-291x(87)91074-6. PMID: 3675593.
121. Fan TP*, Cox JH, Chisholm PM. Mechanism of action of cyclosporine in preventing cardiac allograft rejection. II. Graft tissue levels of prostacyclin and thromboxane. Transplantation. 1987 Mar;43(3):343-5. doi: 10.1097/00007890- 198703000-00004. PMID: 3547787.
122. Cole OF, Fan TP, Lewis GP. Release of eicosanoids from cultured rat aortic endothelial cells; studies with arachidonic acid and calcium ionophore A23187. Cell Biol Int Rep. 1986 Jun;10(6):407-13. doi: 10.1016/0309-1651(86)90035-4. PMID: 3091278.
123. Cole OF, Fan TP, Lewis GP. Isolation, characterisation, growth and culture of endothelial cells from the rat aorta. Cell Biol Int Rep. 1986 Jun;10(6):399-405. doi: 10.1016/0309-1651(86)90034-2. PMID: 3017582.
124. Fan TP*, Lewis GP. Mechanism of cyclosporin A-induced inhibition of prostacyclin synthesis by macrophages. Prostaglandins. 1985 Nov;30(5):735-47. doi:10.1016/0090-6980(85)90004-8. PMID: 3936119.
125. Fan TP*, Lewis GP. Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts. Br J Pharmacol. 1984 Feb;81(2):361-71. doi: 10.1111/j.1476-5381.1984. tb10087.x.PMID: 6423022; PMCID: PMC1986882.
126. Fan TP*, Lewis GP. Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A. Br J Pharmacol. 1982 Jul;76(3):491-7. doi: 10.1111/j.1476-5381.1982.tb09244.x. PMID: 7049288; PMCID: PMC2071795.
