Contact details

Telephone

 +38 032 261 22 87

Email

stoika.rostyslav@gmail.com

Address

Head and Professor

Department of Regulation of Cell Proliferation and Apoptosis

Institute of Cell Biology

National Academy of Sciences of Ukraine

Drahomanov Street 14/16

79005, Lviv, UKRAINE

 

Rostyslav STOIKA received his PhD degree in Biological Sciences from the National Academy of Sciences of Ukraine in 1993. Later, he took a position in the Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology of National Academy of Sciences of Ukraine. His research projects are (1) Enhancing of effectiveness and addressed action of traditional and experimental medicines via their complexation with and delivery by functionalized nanomaterials; (2) Search for molecular targets of biological action of novel medicines of synthetic and natural origin. 

Research

Development of functionalized nanomaterials for improving the biological activity of anticancer drugs.

Development of new leading compounds with high anticancer activity.

Search for the potential molecular targets of anticancer drugs.

Funding (year, title, source, amount, role)

 

1. D. Šponarová, D. Horák, M. Trchová, P. Jendelová, V. Herynek, N. Mitina, A. Zaichenko, R. Stoika, P. Lesný, E. Syková The use of oligoperoxide-coated magnetic nanoparticles to label stem cells // J. Biomed. Nanotechnol. 2011. – V. 7, N 3. – P. 384–394 (ISSN: 1550-7033. (IF:7.578)

2. T. Shagotova, D. Horák, N. Mitina, M. Trchová, N. Boiko, M. Babič, R. Stoika, J. Kovářová, O. Hevus, M. Beneš, T. Skorokhoda, P. Holler, A. Zaichenko Surface-initiated polymerization of 2-hydroxyethyl methacrylate from heterotelechelic oligoperoxide-coated -Fe2O3 nanoparticles and their engulfment by mammalian cells / // Chemistry of Materials. – 2011. – V. 23. – P. 2637–2649. (IF: 8.238)

3. Prylutska S, Bilyy R, Overchuk M, Bychko A, Andreichenko K, Stoika R, Rybalchenko V, Prylutskyy Y, Tsierkezos NG, Ritter U. Water-soluble pristine fullerenes C60 increase the specific conductivity and capacity of lipid model membrane and form the channels in cellular plasma membrane // J Biomed Nanotechnol.  2012. – Vol. 8(3) – P. 522-527. (IF: 7.578).

4. H. Falfushynska, L. Gnatyshyna, O. Stoliar, N. Mitina, T. Skorokhoda, Y. Filyak, A. Zaichenko, R. Stoika Evaluation of biotargeting and ecotoxicity of Co2+-containing nanoscale polymeric complex by applying multi-marker approach in bivalve mollusk Anodonta cygnea // ChemoSphere.   2012. – Vol.88, N 8.   P. 925–936. (IF: 3.206).

5. S. Prylutska, R. Bilyy, T. Schkandina, A. Bychko, V. Cherepanov, K. Andreichenko, R. Stoika, V. Rybalchenko, Yu Prylutskyy, P. Scharff, U. Ritter Effect of iron-doped multi-walled carbon nanotubes on lipid model and cellular plasma membranes // Materials Science and Engineering. – 2012. – Vol. 32. – Р. 1486–1489 (IF: 2,226). 

6. Filyak Y, Finiuk N, Mitina N, Bilyk O, Titorenko V, Hrydzhuk O, Zaichenko A, Stoika R. A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers // BioTechniques.   2013 – Vol.54(1). – P. 35-43. (IF: 2.669)

7. Semra Zuhal Ficen, Zeliha Guler, Nataliya Mitina, Nataliya Finyuk, Rostyslav Stoika, Alexander Zaichenko, Sebnem Ercelen Ceylan. Biophysical study of novel oligoelectrolyte based non-viral gene delivery systems to mammalian cells // Journal of Gene Medicine, 2013. – Vol. 15, N 5. – P. 193–204 (IF: 2.483) 

8. Prylutska S, Bilyy R, Shkandina T, Rotko D, Bychko A, Cherepanov V, Stoika R, Rybalchenko V, Prylutskyy Y, Tsierkezos N, Ritter U. Comparative study of membranotropic action of single- and multi-walled carbon nanotubes // J Biosci Bioeng.   2013 – Vol. 115(6). – P. 674-679 (IF: 2.149)

9. Senkiv Y., Riabtseva A., Heffeter P., Boiko N., Kowol R.C., Jungwith U., Shlyakhtina Y., Garasevych S.G., Mitina N., Berger W., Zaichenko A., Stoika R. Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/phospholipidic nanocarriers of doxorubicin. // J. Biomedical Nanotechnology. – 2014. – V. 10, N. 7. – P. 1369-1381. (IF: 7.58)

10. Heffeter P., Riabtseva A., Senkiv Y., Kowol R.C., Koerner W., Jungwith U., Mitina N., Keppler B.K., Konstantinova T., Yanchuk I., Stoika R., Zaichenko A., Berger W. Nanoformulation improves activity of the (pre)clinival anticancer ruthenium complex KP1019. // J. Biomedical Nanotechnology. – 2014. – V. 10, N 5 – P. 877-84. (IF: 7.58)

11. Panchuk R.R. Prylutska S.V., Chumak V.V., Skorokhyd N.R., Lehka L.V., Evstigneev M.P., Prylutsky Yu.I., Berger W., Heffeter P., Scharff P., Ritter U., Stoika R.S. Application of С60 fullerene-doxorubicin complex for tumor cell treatment in vitro and in vivo. // J. Biomedical Nanotechnology. 2014. – V. 11, N 7 – P. 1139-1152. (IF: 7.58)

12. Grama S. Boiko N., Bilyy R., Klyuchivska O, Antonyuk V., Stoika R., Horak D. Novel fluorescent poly(glycidyl methacrylate) – silica microspheres. // Eur. Polym. J. – 2014. – V. 56. – P. 92-104. (IF: 3.242)

13. Falfushynska H. Gnatyshyna L., Turta O., Stoliar O., Mitina N., Zaichenko A., Stoika R.. Responses of hepatic metallothioneins and apoptotic activity in Carassius auratus gibelio witness a release of cobalt and zinc from waterborne nanoscale composites. // Comparative Biochemistry & Physiology. Part C. Toxicol. Pharmacol. – 2014. – Vol. 160. N1. – P. 66-74. (IF: 2.860)

14. Hor´ak D., Plichta Z., Starykovych M., Myronovskij S., Kit Y., Chopyak V, Stoika R. Calf thymus histone-conjugated magnetic poly(2-oxoethyl methacrylate) microspheres for affinity isolation of anti-histone IgGs from the blood serum of patients with systemic lupus erythematosus / // RCS Advances. 2015, 5, 63050–63055. (IF: 3.84)

15. Panchuk R.R. Prylutska S.V., Chumak V.V., Skorokhyd N.R., Lehka L.V., Evstigneev M.P., Prylutskyy Yu.I., Berger W., Heffeter P., Scharff P., Ritter U., Stoika R.S. Application of C60 fullerene-doxorubicin complex for tumor cell treatment in vitro and in vivo., // J. Biomed. Nanotechnol. – 2015. – V. 11, N.7. – P. 1139-1152. (IF 5.338)

16. Antonyuk V. Grama S., Plichta Z., Magorivska I., Horak D., Stoika R. Use of specific polysaccharide-immobilized monodisperse poly(glycidyl methacrylate) core-silica shell microspheres for affinity purification of lectins. // Biomed. Chromatography. – 2015.   V. 29 (5).   Р. 783 – 787. (IF: 1.662)

17. Falfushynska H, Gnatyshyna L, Fedoruk O, Mitina N, Zaichenko A, Stoliar O, Stoika R. Hepatic metallothioneins in molecular responses to cobalt, zinc, and their nanoscale polymeric composites in frog Rana ridibunda. // Comp Biochem Physiol C Toxicol Pharmacol.   2015   Jun-Jul; (172-173)   Р.45-56. (IF: 2.301)

18. Tanasienko IV, Yemets AI, Finiuk NS, Stoika RR, Blume YB. DMAEM-based cationic polymers as novel carriers for DNA delivery into cells. // Cell Biol Int.   2015 – Vol. 39(3)   Р.243-245. (IF: 1.933) 

19. Prylutska S. V., G. V. Didenko, Y. I. Prylutskyy, M. P. Evstigneev, G. P. Potebnya, R. R. Panchuk, R. S. Stoika, U. Ritter, P. Scharff Complex of C 60 fullerene with doxorubicin as a promising agent in antitumor therapy // Nanoscale Research Letters   2015 – 10,   P. 499. (IF: 2.584)

20. Riabtseva A. Functional micelles formed by branched polymeric surfactants: Synthesis, characteristics, and application as nanoreactors and carriers / A. Riabtseva, N. Mitina, I. Grytsyna, N. Boiko, V. M. Garamus, H. Stryhanyuk, R. Stoika, A. Zaichenko // European Polymer Journal. – 2016,   V. 75,   P. 406-422. (IF: 3.485)

21. Tomin A. T. Dumych, I. Kril, V. Antonyuk, V. Chopyak, L. Munoz, R. Stoika, M. Herrmann, R. Bilyy Magnetic separation of apoptotic cells with lectin-conjugated microparticles (Magnetische abtrennung apoptotischer zellen mit lektin-konjugierten mikropartikeln) // Materialwissenschaft und Werkstofftechnik. – 2016,   V. 47, Issue 2-3   P. 189–192. (IF: 0.425)

22. Horák D., H. Hlídková, O. Klyuchivska, I. Grytsyna, R. Stoika PEGylation controls attachment and engulfment of monodisperse magnetic poly(2-hydroxyethyl methacrylate) microspheres by murine J774.2 macrophages // Applied Surface Science. – 2017. - Vol. 426.  - P. 315-324 (IF: 3.387)

23. Horak D., H. Hlidkova, Yu. Kit, R. Stoika, V. Antonyuk, S. Myronovsky Magnetic poly(2-hydroxyethyl methacrylate) microspheres for affinity purification of antibodies for early diagnosis of multiple sclerosis patients // Biosci. Rep. – 2017. – Vol. 37(2).  -  Р. 1–10 (IF: 2.906)  

24. Finiuk, N. Stoika, R. Buziashvili, A. Burlaka, O. Blume, Y. Yemets, A. Zaichenko, A. Mitina, N. Miagkota, O. Lobachevska, O. Investigation of novel oligoelectrolyte polymer carriers for their capacity of DNA delivery into plant cells // Plant Cell, Tissue and Organ Culture (PCTOC)   2017, Vol. 131(1),  Р. 27–39 (IF: 2.002)

25. Prylutska S., Panchuk R., Golunski G., Skivka L., Prylutskyy Y., Hurmach V., Skorohyd N., Borowik A., Woziwodzka A., Piosik J., Kyzyma O., Garamus V., Bulavin L., Evstigneev M., Buchelnikov A., Stoika R., Berger W., Ritter U., Scharff P.  C60 fullerene enhances cisplatin anticancer activity and overcomes tumor cell drug resistance // Nano Research, 2017. Vol. 10, N 2, P. 652-671. (IF: 7.354).

 

1. Pаtеnt of Ukraine on invention: Method for isolation of hemostatic chitosan. Аuthors: Lootsik M.D., Bilyy R.O., Lutsik М.М., Stoika R.S. Decision a2015 06305, from 01.08.2016 N 16221/3A/16.

 

Awards and other activities