特聘专家 樊台平教授
2023-08-15 / 李宁编辑
樊台平 教授 英国皇家文艺学会院士 台湾中国医药大学讲座教授 剑桥大学药理学系教授及血管新生及天然药物实验室主任 Email：tpf1000@icloud.com
祖籍浙江温州，生于台湾。早年求学于台湾及香港，后读取英国伦敦大学药理学学士、免疫药理学博士及博士后。1986年至2020年，他在剑桥大学药理学系担任讲师、副教授及血管新生和天然药物实验室主任、硕士、博士、博士后导师。2011年受聘为台湾中国医药大学讲座教授；2015年受聘为西北大学、陕西省“千人计划”特聘教授。
因深受传统中医药的熏陶，樊台平博士曾代表英国皇家学会、外交部与英国贸易投资总署到中国进行学术交流及考察。2006年至今，他当任中医药全球化联盟（Consortium for Globalization of Chinese Medicine, CGCM. www.tcmedicine.org）的英国分会联合主席。2009年，他成为欧盟第七框架计划中医药研究专项副协调员，研究全球医药法规与功能基因组学对中医药学发展的影响。他先后担任欧盟中医药规范研究学会（www.gp-tcm.org）秘书长（2012-2014），候任会长（2015-2016），会长（2017-2018），财长（2019-），率领学会专家组致力与欧洲药品质量管理局EDQM合作，拟将300种中草药纳入《欧洲药典》。2017年6月，华大基因农业应用研究院联合广西药用植物园、深圳国家基因库等机构共同发起“药用植物4.0计划”，致力于充分挖掘药用植物这一重要战略资源的潜在价值，为打造千亿万元中医药民族医药产业服务。樊博士受邀成为“药用植物4.0计划”欧洲地区协调员；同时也受国际标准化组织中医药技术委员会（简称ISO/TC249）之邀，参与更多建立中医药国际标准的工作，促进大健康以及社会经济效益。
樊台平博士担任世界中医药学会联合会（WFCMS）理事会主席团执行委员（2017-2022），中药新药创制专业委员会常务理事（2022-）。受聘为中国医学科学院中国协和医科大学血液学研究所、香港浸会大学中医药学院及华大基因学院荣誉教授，同时在多所国内外大学任客座教授。受邀在国际学术会议、世界知名大学、研究机构及制药公司进行讲座、及学术报告500余次，包括英国、法国、德国、奥地利、比利时、捷克、丹麦、希腊、意大利、卢森堡、荷兰、葡萄牙、瑞士、俄罗斯、中国大陆港澳台、日本、韩国、菲律宾、新加坡、澳大利亚、加拿大、美国。
1997年，樊博士创办并担任血管新生杂志Angiogenesis主编8年（2020影响因子9.596）；2004年，他首次发现并报道了人参皂苷具有双向调节血管生成的作用；2006年，樊台平受邀在第15届国际药理学大会（IUPHAR）做主题报告，借助“君臣住使”配伍法则，阐明了中医药在现代药物发现中的独特优势。（注：4年一次的IUPHAR大会是全球药理学界规模最大、学术水平最高的国际会议。每次只邀请国际20位杰出专家进行重点报告）
历时30余年，樊台平在炎症、免疫药理及天然药物药理学机制的前沿领域，取得了多项原创性和系统性的成果。他联合英国、美国、荷兰、中国、港、澳、台湾的学者及团队承担及参与英国、中国等国际合作课题20余项，参与国际发明专利2项。以血管内皮细胞和分子机制研究，探讨了人参、丹参、当归、远志等提取物及中药复方（如麝香保心丸、丹参滴丸、当归补血汤等）对血管生成的作用机制。在Nature Reviews Drug Discovery（2022影响因子112.288），Science（2022影响因子63.714），Circulation （2022影响因子39.918），Trends in Pharmacological Sciences（2022影响因子17.638），Angiogenesis（2021影响因子10.658），Cancer Research（2022影响因子13.312），PNAS（2022影响因子12.779），British Journal of Pharmacology（2022影响因子9.473）等杂志发表研究论文、文献综述及其他著作150余篇，被引用9700余次；“H指数”=46。
近10年来，樊台平会同西北大学郑晓晖教授带领“生命效应分析科学”团队，以“良关系”之“君-使药对”及现代中西医药“整合-结合-融合”的“合策略”为研究思路，致力于心脑血管、老人痴呆症、癫痫创新药物的创制研究。IDHP（丹参素异丙酣）是专注于缺血性心脑血管疾病防治的1类化学新药，它可显著提高治愈率，减少患者痛苦，与现今市场同类药物相比具有明显原创优势、价效优势，可使更多受众（患者）从自主原创的新药中受益。樊博士联合无锡江南大学蔡宇杰教授，通过功能酶的定点修饰技术和微生物改造，发掘高活性天然产物及其衍生物转化关键酶系及生物合成模块构建高效细胞工厂，系统研究转化过程中的酶催化机制及其微生物合成路径，高效生物合成或酶法转化生成具有抗肿瘤、降血糖、降血脂等高值高活性天然产物及其衍生物。他受聘为山东省科学院生物研究所（济南）特聘教授，与刘可春所长密切合作，建立人类疾病斑马鱼模型与药物筛选工程技术研究中心，致力于活性化合物的筛选与评价、药物作用机理以及创新药物以及安全性研究。
2012年，樊台平应美国Science杂志之邀，作为发起人和主编，以The Art and Science of Traditional Medicine（传统医学的艺术与科学）为专题，于2014-2015年编辑并刊发了一系列中医药以及世界其他地区民族药物领域的前瞻性、战略性研究论文，获得了广泛关注与评述，入选2014年世界中医药十大新闻。
2015年，他应邀于联合国总部联合国学术影响力论坛做全会主旨讲座，以Harnessing Natural Resources for a Better Tomorrow- Health and Healing Through Evidence-based Applications of Traditional Medicine（利用自然资源创造更美好的明天—通过传统医学的循证应用实现健康和康复）为题，运用中医药的优势和血管新生平台探讨传统医药的现状和未来，提升了中医药的国际地位及声誉；论坛期间，积极与其他会员国互动，共同实践世界卫生组织《2014-2023传统医药战略》，以为全人类的健康及医疗做出贡献。
2017年，他应捷克卫生部之邀，筹办并主持国际传统中医药圆桌会议，促成捷克众议院通过中医药立法，并纳入其国家卫生保障体系。该历史性的突破与决定成为了中医药“一带一路”建设的先驱成果，并将辐射到其他中东欧国家及欧盟成员国；2017年，应华大基因农业之邀担任“药用植物4.0计划”欧洲地区协调员，并受聘为北京中医药大学「国家中医体质与治未病研究院」学术委员会委员。2018年入选温州市“海外精英引进计划”创新长期项目。荣获2018年改革开放40周年中医药文化传承特别贡献奖。
2019年，樊台平荣获2019年度中华中医药学会岐黄国际奖，并受中国中医科学院黄璐琦院士及华大基因杨焕民院士聘为“中国药用植物大数据中心”委员。2020年受聘为美国植物药协会英国高级副总裁（https://www.botanicaldrug.org），以及中国食药品区块链专委会国际联盟联席主席。樊博士与深圳Authenmole分子态生物技术公司及浙江中医药大学合作，开发用于预防和治疗冠状病毒感染的优质草药茶。利用专利植物低温萃取高效分离集成技术（PLEESIT），从常见食用植物（如金银花、蒲公英、杏仁、生姜）和中草药（如鱼腥草、白术、黄芩、云芝中分离出纯植物化学物质）同时消除重金属和农药残留。利用已建立的中药方剂的高级分子中药提取物。2020年制备了4种预防和治疗新冠肺炎COVID-19疫情的标准化中药茶。两种配方已经成功地保护了一线医务人员，而另外两种配方在中国武汉的4家医院挽救了大量患者。于2020-2021年英国新冠疫情严峻之时，樊博士与分子态生物技术公司合作，捐赠抗疫包至英国中文教育促进会分发给华侨、华裔使用，并与罗马尼亚Vasile Goldis大学团队合作评估这一系列产品的临床疗效及安全性。
2020年9月，樊博士成为英国48家集团俱乐部副会员Associate Member of The 48 Group Club。2021年6月，英国皇家文艺学会颁予樊教授Fellow of the Royal Society of Arts（FRSA）院士荣衔，以表彰他于血管生成和中医药方面的创新研究对健康和福祉领域做出的贡献。
2022年11月，樊台平及其国际团队以“中药良关系核心效应物质系列关键辨识技术及药物智创实践”国际合作项目，荣获2022年世界中医药学会联合会国际贡献奖-科技进步奖“二等奖”。
2023年4月，受华大基因创始人杨焕明院士之邀，主持第18届国际基因组学大会（张家界、北京、南京、温州）“基因组学与中医药”环节，并以“大数据时代中医药研发进展”讲座，倡议成立“中欧植物药研发中心”。
发表文章：
1. Zhu Y, Yang H, Han L, Mervin LH, Hosseini-Gerami L, Li P, Wright P, Trapotsi MA, Liu K, Fan TP*, Bender A. In silico prediction and biological assessment of novel angiogenesis modulators from traditional Chinese medicine. Front Pharmacol. 2023 Feb 3;14:1116081. doi: 10.3389/fphar.2023.1116081. PMID: 36817116; PMCID: PMC9937659.
2. Deng H, Liang X, Liu J, Zheng X, Fan TP, Cai Y. Advances and perspectives on perylenequinone biosynthesis. Front Microbiol. 2022 Dec 20;13:1070110. doi: 10.3389/fmicb.2022.1070110. PMID: 36605511; PMCID: PMC9808054.
3. Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023 Jan;108:154520. doi: 10.1016/j.phymed.2022.154520. Epub 2022 Oct 22. PMID: 36334386.
4. Bai Y, Jia P, Zhao Y, Yang L, Wang X, Wang X, Wang J, Zhong N, Deng H, Du L, Fang J, Xue Y, Chen Y, Gao S, Feng Y, Yan Y, Xiong T, Liu J, Sun Y, Xie J, He X, An X, Liu P, Xu J, Qin F, Meng X, Yin Q, Yang Q, Gao R, Gao X, Luo K, Li Q, Wang X, Liang J, Yang P, Zhang Y, Liao S, Wang S, Zhao X, Xiao C, Yu J, Liu Q, Wang R, Peng N, Wang X, Guo J, Li X, Liu H, Bai Y, Li Z, Zhang Y, Nan Y, Zhang Q, Zhang X, Lei J, Alberts E, de Man A, Kim HK, Hsu SJ, Jia YS, Riener J, Zheng J, Zhang W, Zheng X, Cai Y, Wang M, Fan TP*, Zheng X. Discovery and therapeutic implications of bioactive dihydroxylated phenolic acids in patients with severe heart disease and conditions associated with inflammation and hypoxia. Pharmacol Res. 2022 Nov;185:106458. doi: 10.1016/j.phrs.2022.106458. Epub 2022 Sep 21. PMID: 36152740.
5. Liang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system. Appl Microbiol Biotechnol. 2022 Sep;106(17):5479-5493. doi: 10.1007/s00253-022-12110-x. Epub 2022 Aug 6. PMID: 35931895.
6. Fu CC, Xu FY, Qian YC, Koo HL, Duan YF, Weng GM, Fan TP, Chen MX, Zhu FY. Secondary Metabolites of Osmanthus fragrans: Metabolism and Medicinal Value. Front Pharmacol. 2022 Jul 18;13:922204. doi: 10.3389/fphar.2022.922204. PMID: 35924042; PMCID: PMC9340074.
7. Liang X, Deng H, Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Overexpression and biochemical characterization of a carboxyspermidine dehydrogenase from Agrobacterium fabrum str. C58 and its application to carboxyspermidine production. J Sci Food Agric. 2022 Jul;102(9):3858-3868. doi: 10.1002/jsfa.11735. Epub 2022 Jan 5. PMID: 34932223.
8. Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Biosynthesis of phenylpyruvic acid from l- phenylalanine using chromosomally engineered Escherichia coli. BiotechnolAppl Biochem. 2022 Oct;69(5):1909-1916. doi: 10.1002/bab.2256. Epub 2021 Oct 12. PMID: 34554609.
9. Liu D, Gou L, Bai Y, Fan TP, Zheng X, Cai Y. Converting the 3-quinuclidinone reductase from Agrobacterium tumefaciens into the ethyl 4-chloroacetoacetate reductase by site-directed mutagenesis. BiotechnolAppl Biochem. 2022 Aug;69(4):1428-1437. doi: 10.1002/bab.2214. Epub 2021 Jul 5. PMID: 34148265.
10. Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID: 33643049; PMCID: PMC7902932.
11. Li Y, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity. Biotechnol Appl Biochem. 2022 Dec;69(6):2530-2539. doi: 10.1002/bab.2302. Epub 2021 Dec 24. PMID: 34902878.
12. Mohamad Zobir SZ, Choi RJ, Modos D, Fan TP, Bender A. Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology. Synergy 11, Supplement, December 2020, 100073. https://doi.org/10.1016/j.synres.2021.100073
13. KalantarMotamedi Y, Choi RJ, Koh SB, Bramhall JL, Fan TP, Bender A. Prediction and identification of synergistic compound combinations against pancreatic cancer cells. iScience. 2021 Sep 3;24(9):103080. doi: 10.1016/j.isci.2021.103080. PMID: 34585118; PMCID: PMC8456050.
14. Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce (including Fan TP); Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. PMID: 33510482; PMCID: PMC7841765.
15. Deng H, Liang W, Fan TP, Zheng X, Cai Y. Modular engineering of Shiraia bambusicola for hypocrellin production through an efficient CRISPR system. Int J Biol Macromol. 2020 Dec 15;165(Pt A):796-803. doi:10.1016/j.ijbiomac.2020.09.208. Epub 2020 Sep 30. PMID: 33010268.
16. Liu J, Bai Y, Fan TP, Zheng X, Cai Y. Unveiling the Multipath Biosynthesis Mechanism of 2-Phenylethanol in Proteus mirabilis. JAgric Food Chem. 2020 Jul 22;68(29):7684-7690. doi: 10.1021/acs.jafc.0c02918. Epub 2020 Jul 10. PMID: 32608230.
17. Hu X, Bai Y, Fan TP, Zheng X, Cai Y. A novel type alanine dehydrogenase fromHelicobacter aurati: Molecular characterization and application. Int J Biol Macromol. 2020 Oct 15;161:636-642. doi: 10.1016/j.ijbiomac.2020.06.067. Epub 2020 Jun 10. PMID: 32534087.
18. Liang W, Xiong T, Wang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. A novel feruloyl esterase with high rosmarinic acid hydrolysis activity from Bacillus pumilus W3. Int J Biol Macromol. 2020 Oct 15;161:525-530. doi:10.1016/j.ijbiomac.2020.06.038. Epub 2020 Jun 9. PMID: 32531366.
2. Deng H, Liang X, Liu J, Zheng X, Fan TP, Cai Y. Advances and perspectives on perylenequinone biosynthesis. Front Microbiol. 2022 Dec 20;13:1070110. doi: 10.3389/fmicb.2022.1070110. PMID: 36605511; PMCID: PMC9808054.
3. Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B. The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis. Phytomedicine. 2023 Jan;108:154520. doi: 10.1016/j.phymed.2022.154520. Epub 2022 Oct 22. PMID: 36334386.
4. Bai Y, Jia P, Zhao Y, Yang L, Wang X, Wang X, Wang J, Zhong N, Deng H, Du L, Fang J, Xue Y, Chen Y, Gao S, Feng Y, Yan Y, Xiong T, Liu J, Sun Y, Xie J, He X, An X, Liu P, Xu J, Qin F, Meng X, Yin Q, Yang Q, Gao R, Gao X, Luo K, Li Q, Wang X, Liang J, Yang P, Zhang Y, Liao S, Wang S, Zhao X, Xiao C, Yu J, Liu Q, Wang R, Peng N, Wang X, Guo J, Li X, Liu H, Bai Y, Li Z, Zhang Y, Nan Y, Zhang Q, Zhang X, Lei J, Alberts E, de Man A, Kim HK, Hsu SJ, Jia YS, Riener J, Zheng J, Zhang W, Zheng X, Cai Y, Wang M, Fan TP*, Zheng X. Discovery and therapeutic implications of bioactive dihydroxylated phenolic acids in patients with severe heart disease and conditions associated with inflammation and hypoxia. Pharmacol Res. 2022 Nov;185:106458. doi: 10.1016/j.phrs.2022.106458. Epub 2022 Sep 21. PMID: 36152740.
5. Liang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Highly efficient biosynthesis of spermidine from L-homoserine and putrescine using an engineered Escherichia coli with NADPH self-sufficient system. Appl Microbiol Biotechnol. 2022 Sep;106(17):5479-5493. doi: 10.1007/s00253-022-12110-x. Epub 2022 Aug 6. PMID: 35931895.
6. Fu CC, Xu FY, Qian YC, Koo HL, Duan YF, Weng GM, Fan TP, Chen MX, Zhu FY. Secondary Metabolites of Osmanthus fragrans: Metabolism and Medicinal Value. Front Pharmacol. 2022 Jul 18;13:922204. doi: 10.3389/fphar.2022.922204. PMID: 35924042; PMCID: PMC9340074.
7. Liang X, Deng H, Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Overexpression and biochemical characterization of a carboxyspermidine dehydrogenase from Agrobacterium fabrum str. C58 and its application to carboxyspermidine production. J Sci Food Agric. 2022 Jul;102(9):3858-3868. doi: 10.1002/jsfa.11735. Epub 2022 Jan 5. PMID: 34932223.
8. Xiong T, Bai Y, Fan TP, Zheng X, Cai Y. Biosynthesis of phenylpyruvic acid from l- phenylalanine using chromosomally engineered Escherichia coli. BiotechnolAppl Biochem. 2022 Oct;69(5):1909-1916. doi: 10.1002/bab.2256. Epub 2021 Oct 12. PMID: 34554609.
9. Liu D, Gou L, Bai Y, Fan TP, Zheng X, Cai Y. Converting the 3-quinuclidinone reductase from Agrobacterium tumefaciens into the ethyl 4-chloroacetoacetate reductase by site-directed mutagenesis. BiotechnolAppl Biochem. 2022 Aug;69(4):1428-1437. doi: 10.1002/bab.2214. Epub 2021 Jul 5. PMID: 34148265.
10. Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID: 33643049; PMCID: PMC7902932.
11. Li Y, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a putative tropinone reductase from Tarenaya hassleriana with a broad substrate specificity. Biotechnol Appl Biochem. 2022 Dec;69(6):2530-2539. doi: 10.1002/bab.2302. Epub 2021 Dec 24. PMID: 34902878.
12. Mohamad Zobir SZ, Choi RJ, Modos D, Fan TP, Bender A. Predicting and understanding synergistic pairwise compound combinations of Shexian Baoxin Pill (SBP) using network biology. Synergy 11, Supplement, December 2020, 100073. https://doi.org/10.1016/j.synres.2021.100073
13. KalantarMotamedi Y, Choi RJ, Koh SB, Bramhall JL, Fan TP, Bender A. Prediction and identification of synergistic compound combinations against pancreatic cancer cells. iScience. 2021 Sep 3;24(9):103080. doi: 10.1016/j.isci.2021.103080. PMID: 34585118; PMCID: PMC8456050.
14. Atanasov AG, Zotchev SB, Dirsch VM; International Natural Product Sciences Taskforce (including Fan TP); Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021 Mar;20(3):200-216. doi: 10.1038/s41573-020-00114-z. Epub 2021 Jan 28. PMID: 33510482; PMCID: PMC7841765.
15. Deng H, Liang W, Fan TP, Zheng X, Cai Y. Modular engineering of Shiraia bambusicola for hypocrellin production through an efficient CRISPR system. Int J Biol Macromol. 2020 Dec 15;165(Pt A):796-803. doi:10.1016/j.ijbiomac.2020.09.208. Epub 2020 Sep 30. PMID: 33010268.
16. Liu J, Bai Y, Fan TP, Zheng X, Cai Y. Unveiling the Multipath Biosynthesis Mechanism of 2-Phenylethanol in Proteus mirabilis. JAgric Food Chem. 2020 Jul 22;68(29):7684-7690. doi: 10.1021/acs.jafc.0c02918. Epub 2020 Jul 10. PMID: 32608230.
17. Hu X, Bai Y, Fan TP, Zheng X, Cai Y. A novel type alanine dehydrogenase fromHelicobacter aurati: Molecular characterization and application. Int J Biol Macromol. 2020 Oct 15;161:636-642. doi: 10.1016/j.ijbiomac.2020.06.067. Epub 2020 Jun 10. PMID: 32534087.
18. Liang W, Xiong T, Wang X, Deng H, Bai Y, Fan TP, Zheng X, Cai Y. A novel feruloyl esterase with high rosmarinic acid hydrolysis activity from Bacillus pumilus W3. Int J Biol Macromol. 2020 Oct 15;161:525-530. doi:10.1016/j.ijbiomac.2020.06.038. Epub 2020 Jun 9. PMID: 32531366.
19. Deng H, Bai Y, Fan TP, Zheng X, Cai Y. Advanced strategy for metabolite exploration in filamentous fungi. Crit Rev Biotechnol. 2020 Mar;40(2):180-198. doi: 10.1080/07388551.2019.1709798. Epub 2020 Jan 6. PMID: 31906740.
20. Yan Y, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Production of rosmarinic acid with ATP and CoA double regenerating system. Enzyme Microb Technol. 2019 Dec;131:109392. doi: 10.1016/j.enzmictec.2019.109392. Epub 2019 Aug 5. PMID: 31615678.
21. Bai Y, He X, Bai Y, Sun Y, Zhao Z, Chen X, Li B, Xie J, Li Y, Jia P, Meng X, Zhao Y, Ding Y, Xiao C, Wang S, Yu J, Liao S, Zhang Y, Zhu Z, Zhang Q, Zhao Y, Qin F, Zhang Y, Wei X, Zeng M, Liang J, Cuan Y, Shan G, Fan TP, Wu B, Zheng X. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study. Eur J Med Chem. 2019 Dec 1;183:111650. doi: 10.1016/j.ejmech.2019.111650. Epub 2019 Sep 6. PMID: 31539780.
22. Iqbal M, Fan TP, Watson D, Alenezi S, Saleh K, Sahlan M. Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon. 2019 Jul 19;5(7):e01978. doi: 10.1016/j.heliyon.2019.e01978. PMID: 31372523; PMCID: PMC6656927.
23. Deng H, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. Expression and characterisation offeruloyl esterases from Lactobacillus fermentum JN248 and release offerulic acid from wheat bran. Int J Biol Macromol. 2019 Oct 1;138:272- 277. doi: 10.1016/j.ijbiomac.2019.07.086. Epub 2019 Jul 12. PMID: 31306699.
24. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Redox self-sufficient biocatalyst system for conversion of 3,4-Dihydroxyphenyl-L-alanine into (R)- or (S)- 3,4-Dihydroxyphenyllactic acid. J Ind Microbiol Biotechnol. 2019 Aug;46(8):1081-1090. doi: 10.1007/s10295-019-02200-7. Epub 2019 Jun 14. PMID: 31201648.
25. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Biosynthesis of D- danshensu from L-DOPA using engineered Escherichia coli whole cells. Appl Microbiol Biotechnol. 2019 Aug;103(15):6097-6105. doi: 10.1007/s00253-019- 09947-0. Epub 2019 Jun 11. PMID: 31187210.
26. Li C, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Efficient Synthesis of Hydroxytyrosol from l-3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole Cells. JAgric Food Chem. 2019 Jun 19;67(24):6867-6873. doi: 10.1021/acs.jafc.9b01856. Epub 2019 Jun 6. PMID: 31134807.
27. Xiong T, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. J Biotechnol. 2019 Jul 20;300:48-54. doi: 10.1016/j.jbiotec.2019.05.008. Epub 2019 May 21. PMID: 31125578.
28. Liao S, Han L, Zheng X, Wang X, Zhang P, Wu J, Liu R, Fu Y, Sun J, Kang X, Liu K, Fan TP, Li S, Zheng X. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019 Sep;176(17):3143-3160. doi: 10.1111/bph.14714. Epub 2019 Jul 9. Erratum in: Br J Pharmacol. 2021 Jul;178(14):2905. PMID: 31116880; PMCID: PMC6692590.
29. Sun Y, Bai Y, Zeng M, Chen X, Xie J, Li B, He X, Bai Y, Jia P, Meng X, Liang J, Wang S, Fan TP, Wu B, Zheng X. Pharmacokinetics and tissue distribution evaluation of α-asaronol and its main metabolite in rats by HPLC method. J Pharm Biomed Anal. 2019 Aug 5;172:349-356. doi: 10.1016/j.jpba.2019.05.004. Epub 2019 May 3. PMID: 31085397.
30. Yu F, Bai Y, Fan TP, Zheng X, Cai Y. Alcohol dehydrogenases from Proteus mirabilis contribute to alcoholic flavor. J Sci Food Agric. 2019 Jun;99(8):4123-4128. doi: 10.1002/jsfa.9642. Epub 2019 Mar 18. PMID: 30761541.
31. Wang YH, Bai YJ, Fan TP, Zheng XH, Cai YJ. Reducing 3,4-dihydroxyphenylpyruvic acid to d-3,4-dihydroxyphenyllactic acid via a coenzyme nonspecific d-lactate dehydrogenase from Lactobacillus reuteri. JAppl Microbiol. 2018 Aug 21. doi: 10.1111/jam.14077. Epub ahead of print. PMID: 30129993.
32. Liu J, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JAgric Food Chem. 2018 Apr 4;66(13):3498-3504. doi:10.1021/acs.jafc.8b00627. Epub 2018 Mar 23. PMID: 29560727.
33. He X, Bai Y, Zeng M, Zhao Z, Zhang Q, Xu N, Qin F, Wei X, Zhao M, Wu N, Li Z, Zhang Y, Fan TP, Zheng X. Anticonvulsant activities of α-asaronol ((E)-3'-hydroxyasarone), an active constituent derived from α-asarone. Pharmacol Rep. 2018 Feb;70(1):69-74. doi: 10.1016/j.pharep.2017.08.004. Epub 2017 Aug 31.PMID: 29331789.
34. Chen L, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a d-Lactate Dehydrogenase from Lactobacillus fermentum JN248 with High Phenylpyruvate Reductive Activity. J Food Sci. 2017 Oct;82(10):2269-2275. doi: 10.1111/1750- 3841.13863. Epub 2017 Sep 7. PMID: 28881036.
35. Chang FW, Fan HC, Liu JM, Fan TP, Jing J, Yang CL, Hsu RJ. Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors. Int J Mol Sci. 2017 Jan 14;18(1):163. doi: 10.3390/ijms18010163. PMID: 28098816; PMCID: PMC5297796.
36. Choi RJ, Roy A, Jung HJ, Ali MY, Min BS, Park CH, Yokozawa T, Fan TP, Choi JS, Jung HA. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J Ethnopharmacol. 2016 Aug 22;190:219-30. doi:10.1016/j.jep.2016. 06.013. Epub 2016 Jun 5. PMID: 27275774.
37. Mohamad Zobir SZ, Mohd Fauzi F, Liggi S, Drakakis G, Fu X, Fan TP*, Bender A. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evid Based Complement Alternat Med. 2016;2016:2106465. doi: 10.1155/2016/2106465. Epub 2016 Feb 18. PMID: 26989424; PMCID: PMC4775820.
38. Choi RJ, Wong AST, Jia W, Chang I-M, Wong RNS, Fan TP*, Kim YS (2015) Ginseng: A panacea linking East Asia and North America? Science 350 (6262 Suppl) S54-S56.
39. Schroen Y, Wang M, van Wietmarschen HA, Witkamp R, Hankemeier T, Fan TP, van der Greef J. (2015) Bridging the seen and the unseen: A systems pharmacology view of herbal medicine. Science 350 (6262 Suppl) S66-S69.
40. Jia W, Fan TP, Wang X, Xie G. (2015) The polypharmacokinetics of herbal medicine. Science 350 (6262 Suppl) S76-S78.
41. Yang XY, He K, Pan CS, Li Q, Liu YY, Yan L, Wei XH, Hu BH, Chang X, Mao XW, Huang DD, Wang LJ, Hu SW, Jiang Y, Wang GC, Fan JY, Fan TP, Han JY. 3, 4- dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury. Sci Rep. 2015 Jun 1;5:10739. doi: 10.1038/srep10739. PMID: 26030156; PMCID: PMC5377067.
42. Yin Q, Lu H, Bai Y, Tian A, Yang Q, Wu J, Yang C, Fan TP, Zhang Y, Zheng X, Zheng X, Li Z. A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. Br J Pharmacol. 2015 Dec;172(23):5573-85. doi: 10.1111/bph.13133. Epub 2015 May 5. PMID: 25766073; PMCID: PMC4667860.
43. Liu R, Runyon S, Wang Y, Oliver SG, Fan TP*, Zhang W (2015) Deciphering ancient combinatorial formulas: The Shexiang Baoxin pill. Science 347 (6219 Suppl) S40-S42.
44. Zhao, X, Zheng X, Fan, TP*, Li Z, Zhang Y, Zheng J* (2015) A novel drug discovery strategy inspired by traditional medicine philosophies. Science 347 (6219 Suppl) S38-S40.
20. Yan Y, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Production of rosmarinic acid with ATP and CoA double regenerating system. Enzyme Microb Technol. 2019 Dec;131:109392. doi: 10.1016/j.enzmictec.2019.109392. Epub 2019 Aug 5. PMID: 31615678.
21. Bai Y, He X, Bai Y, Sun Y, Zhao Z, Chen X, Li B, Xie J, Li Y, Jia P, Meng X, Zhao Y, Ding Y, Xiao C, Wang S, Yu J, Liao S, Zhang Y, Zhu Z, Zhang Q, Zhao Y, Qin F, Zhang Y, Wei X, Zeng M, Liang J, Cuan Y, Shan G, Fan TP, Wu B, Zheng X. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study. Eur J Med Chem. 2019 Dec 1;183:111650. doi: 10.1016/j.ejmech.2019.111650. Epub 2019 Sep 6. PMID: 31539780.
22. Iqbal M, Fan TP, Watson D, Alenezi S, Saleh K, Sahlan M. Preliminary studies: the potential anti-angiogenic activities of two Sulawesi Island (Indonesia) propolis and their chemical characterization. Heliyon. 2019 Jul 19;5(7):e01978. doi: 10.1016/j.heliyon.2019.e01978. PMID: 31372523; PMCID: PMC6656927.
23. Deng H, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. Expression and characterisation offeruloyl esterases from Lactobacillus fermentum JN248 and release offerulic acid from wheat bran. Int J Biol Macromol. 2019 Oct 1;138:272- 277. doi: 10.1016/j.ijbiomac.2019.07.086. Epub 2019 Jul 12. PMID: 31306699.
24. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Redox self-sufficient biocatalyst system for conversion of 3,4-Dihydroxyphenyl-L-alanine into (R)- or (S)- 3,4-Dihydroxyphenyllactic acid. J Ind Microbiol Biotechnol. 2019 Aug;46(8):1081-1090. doi: 10.1007/s10295-019-02200-7. Epub 2019 Jun 14. PMID: 31201648.
25. Xiong T, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Biosynthesis of D- danshensu from L-DOPA using engineered Escherichia coli whole cells. Appl Microbiol Biotechnol. 2019 Aug;103(15):6097-6105. doi: 10.1007/s00253-019- 09947-0. Epub 2019 Jun 11. PMID: 31187210.
26. Li C, Jia P, Bai Y, Fan TP, Zheng X, Cai Y. Efficient Synthesis of Hydroxytyrosol from l-3,4-Dihydroxyphenylalanine Using Engineered Escherichia coli Whole Cells. JAgric Food Chem. 2019 Jun 19;67(24):6867-6873. doi: 10.1021/acs.jafc.9b01856. Epub 2019 Jun 6. PMID: 31134807.
27. Xiong T, Jia P, Jiang J, Bai Y, Fan TP, Zheng X, Cai Y. One-pot, three-step cascade synthesis of D-danshensu using engineered Escherichia coli whole cells. J Biotechnol. 2019 Jul 20;300:48-54. doi: 10.1016/j.jbiotec.2019.05.008. Epub 2019 May 21. PMID: 31125578.
28. Liao S, Han L, Zheng X, Wang X, Zhang P, Wu J, Liu R, Fu Y, Sun J, Kang X, Liu K, Fan TP, Li S, Zheng X. Tanshinol borneol ester, a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019 Sep;176(17):3143-3160. doi: 10.1111/bph.14714. Epub 2019 Jul 9. Erratum in: Br J Pharmacol. 2021 Jul;178(14):2905. PMID: 31116880; PMCID: PMC6692590.
29. Sun Y, Bai Y, Zeng M, Chen X, Xie J, Li B, He X, Bai Y, Jia P, Meng X, Liang J, Wang S, Fan TP, Wu B, Zheng X. Pharmacokinetics and tissue distribution evaluation of α-asaronol and its main metabolite in rats by HPLC method. J Pharm Biomed Anal. 2019 Aug 5;172:349-356. doi: 10.1016/j.jpba.2019.05.004. Epub 2019 May 3. PMID: 31085397.
30. Yu F, Bai Y, Fan TP, Zheng X, Cai Y. Alcohol dehydrogenases from Proteus mirabilis contribute to alcoholic flavor. J Sci Food Agric. 2019 Jun;99(8):4123-4128. doi: 10.1002/jsfa.9642. Epub 2019 Mar 18. PMID: 30761541.
31. Wang YH, Bai YJ, Fan TP, Zheng XH, Cai YJ. Reducing 3,4-dihydroxyphenylpyruvic acid to d-3,4-dihydroxyphenyllactic acid via a coenzyme nonspecific d-lactate dehydrogenase from Lactobacillus reuteri. JAppl Microbiol. 2018 Aug 21. doi: 10.1111/jam.14077. Epub ahead of print. PMID: 30129993.
32. Liu J, Jiang J, Bai Y, Fan TP, Zhao Y, Zheng X, Cai Y. Mimicking a New 2-Phenylethanol Production Pathway from Proteus mirabilis JN458 in Escherichia coli. JAgric Food Chem. 2018 Apr 4;66(13):3498-3504. doi:10.1021/acs.jafc.8b00627. Epub 2018 Mar 23. PMID: 29560727.
33. He X, Bai Y, Zeng M, Zhao Z, Zhang Q, Xu N, Qin F, Wei X, Zhao M, Wu N, Li Z, Zhang Y, Fan TP, Zheng X. Anticonvulsant activities of α-asaronol ((E)-3'-hydroxyasarone), an active constituent derived from α-asarone. Pharmacol Rep. 2018 Feb;70(1):69-74. doi: 10.1016/j.pharep.2017.08.004. Epub 2017 Aug 31.PMID: 29331789.
34. Chen L, Bai Y, Fan TP, Zheng X, Cai Y. Characterization of a d-Lactate Dehydrogenase from Lactobacillus fermentum JN248 with High Phenylpyruvate Reductive Activity. J Food Sci. 2017 Oct;82(10):2269-2275. doi: 10.1111/1750- 3841.13863. Epub 2017 Sep 7. PMID: 28881036.
35. Chang FW, Fan HC, Liu JM, Fan TP, Jing J, Yang CL, Hsu RJ. Estrogen Enhances the Expression of the Multidrug Transporter Gene ABCG2-Increasing Drug Resistance of Breast Cancer Cells through Estrogen Receptors. Int J Mol Sci. 2017 Jan 14;18(1):163. doi: 10.3390/ijms18010163. PMID: 28098816; PMCID: PMC5297796.
36. Choi RJ, Roy A, Jung HJ, Ali MY, Min BS, Park CH, Yokozawa T, Fan TP, Choi JS, Jung HA. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J Ethnopharmacol. 2016 Aug 22;190:219-30. doi:10.1016/j.jep.2016. 06.013. Epub 2016 Jun 5. PMID: 27275774.
37. Mohamad Zobir SZ, Mohd Fauzi F, Liggi S, Drakakis G, Fu X, Fan TP*, Bender A. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evid Based Complement Alternat Med. 2016;2016:2106465. doi: 10.1155/2016/2106465. Epub 2016 Feb 18. PMID: 26989424; PMCID: PMC4775820.
38. Choi RJ, Wong AST, Jia W, Chang I-M, Wong RNS, Fan TP*, Kim YS (2015) Ginseng: A panacea linking East Asia and North America? Science 350 (6262 Suppl) S54-S56.
39. Schroen Y, Wang M, van Wietmarschen HA, Witkamp R, Hankemeier T, Fan TP, van der Greef J. (2015) Bridging the seen and the unseen: A systems pharmacology view of herbal medicine. Science 350 (6262 Suppl) S66-S69.
40. Jia W, Fan TP, Wang X, Xie G. (2015) The polypharmacokinetics of herbal medicine. Science 350 (6262 Suppl) S76-S78.
41. Yang XY, He K, Pan CS, Li Q, Liu YY, Yan L, Wei XH, Hu BH, Chang X, Mao XW, Huang DD, Wang LJ, Hu SW, Jiang Y, Wang GC, Fan JY, Fan TP, Han JY. 3, 4- dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury. Sci Rep. 2015 Jun 1;5:10739. doi: 10.1038/srep10739. PMID: 26030156; PMCID: PMC5377067.
42. Yin Q, Lu H, Bai Y, Tian A, Yang Q, Wu J, Yang C, Fan TP, Zhang Y, Zheng X, Zheng X, Li Z. A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. Br J Pharmacol. 2015 Dec;172(23):5573-85. doi: 10.1111/bph.13133. Epub 2015 May 5. PMID: 25766073; PMCID: PMC4667860.
43. Liu R, Runyon S, Wang Y, Oliver SG, Fan TP*, Zhang W (2015) Deciphering ancient combinatorial formulas: The Shexiang Baoxin pill. Science 347 (6219 Suppl) S40-S42.
44. Zhao, X, Zheng X, Fan, TP*, Li Z, Zhang Y, Zheng J* (2015) A novel drug discovery strategy inspired by traditional medicine philosophies. Science 347 (6219 Suppl) S38-S40.
45. Chen S*, Song J, Sun C, Xu J, Zhu Y, Verpoorte R, Fan TP*. (2015) Herbal genomics: Examining the biology of traditional medicines Science 347 (6219 Suppl) S27-S29.
46. Fan TP, Briggs J, Liu A, Liu L, Xu A (2014) Integrating traditional medicine into modern health care. Science 346 (6216 Suppl) S4.
47. Zhao X, Li Q, Xiao C, Zhang Y, Bian L, Zheng J, Zheng X, Li Z, Zhang Y, Fan TP* (2014) Oriented immobilisation of histidine-tagged protein and its application in exploring interactions between ligands and proteins. Analytical & Bioanalytical Chemistry 406: 2975-2985.
48. Chen CY, Chou KC, Adams JD, Fan TP, Litscher G. Recent novel high-tech researches in molecular biology. Biomed Res Int. 2015;2015:749160. doi: 10.1155/2015/749160. Epub 2015 Jan 28. PMID: 25695089; PMCID: PMC4324116.
49. Pelkonen O, Xu Q, Fan TP. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J Tradit Complement Med. 2014 Jan;4(1):1-7. doi: 10.4103/2225-4110.124323. PMID: 24872927; PMCID: PMC4032837.
50. Li Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, Liao Y, Pan R, Fan TP*. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014;2014:392324. doi: 10.1155/2014/392324. Epub 2014 Mar 12. PMID: 24744810; PMCID: PMC3972950.
51. Li S, Fan TP, Jia W, Lu A, Zhang W. Network pharmacology in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014;2014:138460. doi: 10.1155/2014/138460. Epub 2014 Feb 24. PMID: 24707305; PMCID: PMC3953584.
52. Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A.(2013) Linking Ayurveda and Western medicine by integrative analysis. J Ayurveda Integr Med. 4:117-9. doi: 10.4103/0975-9476.113882.
53. Xu Q, Bauer R, Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, Guo DA, Hylands PJ. The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med. 2013 Jun 13;13:132. doi: 10.1186/1472-6882-13-132. PMID: 23763836; PMCID: PMC3689083.
54. Mohd Fauzi F, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A. Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines. J Chem Inf Model. 2013 Mar 25;53(3):661-73. doi: 10.1021/ci3005513. Epub 2013 Feb 18. PMID: 23351136.
55. Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, Fan TP, Liu C. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963. doi: 10.1155/2012/284963. Epub 2012 Jul 29. PMID: 22927877; PMCID: PMC3424634.
56. Wei XH, Liu YY, Li Q, Yan L, Hu BH, Pan CS, Li ZX, Chang X, Fan JY, Zhao N, Sun K, Huang P, Wang CS, Fan TP, Han JY. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002. PMID: 22913380.
57. Yeh JC, Garrard IJ, Cho CW, Annie Bligh SW, Lu GH, Fan TP*, Fisher D. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. J ChromatogrA. 2012 May 4;1236:132-8. doi: 10.1016/j.chroma.2012.03.013. Epub 2012 Mar 9. PMID: 22458966.
58. Uzuner H, Bauer R, Fan TP, Guo DA, Dias A, El-Nezami H, Efferth T, Williamson EM, Heinrich M, Robinson N, Hylands PJ, Hendry BM, Cheng YC, Xu Q. Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. J Ethnopharmacol. 2012 Apr 10;140(3):458-68. doi: 10.1016/j.jep.2012.02.028. Epub 2012 Feb 23. PMID: 22387462.
46. Fan TP, Briggs J, Liu A, Liu L, Xu A (2014) Integrating traditional medicine into modern health care. Science 346 (6216 Suppl) S4.
47. Zhao X, Li Q, Xiao C, Zhang Y, Bian L, Zheng J, Zheng X, Li Z, Zhang Y, Fan TP* (2014) Oriented immobilisation of histidine-tagged protein and its application in exploring interactions between ligands and proteins. Analytical & Bioanalytical Chemistry 406: 2975-2985.
48. Chen CY, Chou KC, Adams JD, Fan TP, Litscher G. Recent novel high-tech researches in molecular biology. Biomed Res Int. 2015;2015:749160. doi: 10.1155/2015/749160. Epub 2015 Jan 28. PMID: 25695089; PMCID: PMC4324116.
49. Pelkonen O, Xu Q, Fan TP. Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality? J Tradit Complement Med. 2014 Jan;4(1):1-7. doi: 10.4103/2225-4110.124323. PMID: 24872927; PMCID: PMC4032837.
50. Li Z, Liu Y, Wang L, Liu X, Chang Q, Guo Z, Liao Y, Pan R, Fan TP*. Memory-Enhancing Effects of the Crude Extract of Polygala tenuifolia on Aged Mice. Evid Based Complement Alternat Med. 2014;2014:392324. doi: 10.1155/2014/392324. Epub 2014 Mar 12. PMID: 24744810; PMCID: PMC3972950.
51. Li S, Fan TP, Jia W, Lu A, Zhang W. Network pharmacology in Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014;2014:138460. doi: 10.1155/2014/138460. Epub 2014 Feb 24. PMID: 24707305; PMCID: PMC3953584.
52. Fauzi FM, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A.(2013) Linking Ayurveda and Western medicine by integrative analysis. J Ayurveda Integr Med. 4:117-9. doi: 10.4103/0975-9476.113882.
53. Xu Q, Bauer R, Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, Guo DA, Hylands PJ. The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med. 2013 Jun 13;13:132. doi: 10.1186/1472-6882-13-132. PMID: 23763836; PMCID: PMC3689083.
54. Mohd Fauzi F, Koutsoukas A, Lowe R, Joshi K, Fan TP, Glen RC, Bender A. Chemogenomics approaches to rationalizing the mode-of-action of traditional Chinese and Ayurvedic medicines. J Chem Inf Model. 2013 Mar 25;53(3):661-73. doi: 10.1021/ci3005513. Epub 2013 Feb 18. PMID: 23351136.
55. Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, Fan TP, Liu C. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963. doi: 10.1155/2012/284963. Epub 2012 Jul 29. PMID: 22927877; PMCID: PMC3424634.
56. Wei XH, Liu YY, Li Q, Yan L, Hu BH, Pan CS, Li ZX, Chang X, Fan JY, Zhao N, Sun K, Huang P, Wang CS, Fan TP, Han JY. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002. PMID: 22913380.
57. Yeh JC, Garrard IJ, Cho CW, Annie Bligh SW, Lu GH, Fan TP*, Fisher D. Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles. J ChromatogrA. 2012 May 4;1236:132-8. doi: 10.1016/j.chroma.2012.03.013. Epub 2012 Mar 9. PMID: 22458966.
58. Uzuner H, Bauer R, Fan TP, Guo DA, Dias A, El-Nezami H, Efferth T, Williamson EM, Heinrich M, Robinson N, Hylands PJ, Hendry BM, Cheng YC, Xu Q. Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. J Ethnopharmacol. 2012 Apr 10;140(3):458-68. doi: 10.1016/j.jep.2012.02.028. Epub 2012 Feb 23. PMID: 22387462.
59. Fan TP*, Deal G, Koo HL, Rees D, Sun H, Chen S, Dou JH, Makarov VG, Pozharitskaya ON, Shikov AN, Kim YS, Huang YT, Chang YS, Jia W, Dias A, Wong VC, Chan K. Future development of global regulations of Chinese herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):568-86. doi:10.1016/j.jep.2012.02.029. Epub 2012 Feb 25. PMID: 22373513.
60. Pelkonen O, Pasanen M, Lindon JC, Chan K, Zhao L, Deal G, Xu Q, Fan TP. Omics and its potential impact on R&D and regulation of complex herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):587-93. doi: 10.1016/j.jep.2012.01.035. Epub 2012 Feb 1. PMID: 22313626.
61. Xu SP, Yang YY, Xue D, Liu JX, Liu XM, Fan TP, le Pan R, Li P. Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice. Evid Based Complement Alternat Med. 2011;2011:839720. doi:10.1155/2011/839720. Epub 2011 Mar 6. PMID: 21423642; PMCID: PMC3057668.
62. Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP*. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15. PMID: 21327473.
63. Uzuner H, Fan TP, Dias A, Guo DA, El-Nezami HS, Xu Q. Establishing an EU-China consortium on traditional Chinese medicine research. Chin Med. 2010 Dec 14;5:42. doi: 10.1186/1749-8546-5-42. PMID: 21156056; PMCID: PMC3019128.
64. Lee YM, Ting CM, Cheng YK, Fan TP, Wong RN, Lung ML, Mak NK. Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells. Cancer Lett. 2008 Sep 18;268(2):295-307. doi: 10.1016/j.canlet.2008.04.010. Epub 2008 May 19. PMID: 18492602.
65. Li P, Xu G, Li SP, Wang YT, Fan TP, Zhao QS, Zhang QW. Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. JAgric Food Chem. 2008 Feb 27;56(4):1164-71. doi: 10.1021/jf073020u. Epub 2008 Jan 17. PMID: 18198831.
66. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2008 Jan 11;365(2):285-90. doi: 10.1016/j.bbrc.2007.10.166. Epub 2007 Nov 5. PMID: 17986384.
67. Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran- Tink J, Wong AS. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007 Sep;152(2):207-15. doi: 10.1038/sj.bjp.0707359. Epub 2007 Jul 2. Erratum in: Br J Pharmacol. 2020 Jan;177(1):236. PMID: 17603552; PMCID: PMC1978254.
68. Bapna A, Federici L, Venter H, Velamakanni S, Luisi B, Fan TP, van Veen HW. Two proton translocation pathways in a secondary active multidrug transporter. J Mol Microbiol Biotechnol. 2007;12(3-4):197-209. doi: 10.1159/000099641. PMID: 17587868.
69. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan TP, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007 May 15;2:6. doi: 10.1186/1749-8546-2-6. PMID: 17502003; PMCID: PMC1876803.
70. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, NgTB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007;14(12):1371-80. doi: 10.2174/092986707780597916. PMID: 17504218.
71. Lim MW, Fan TP. A "pancreatic tooth" design best accommodates the limitations of current artificial pancreas technology. Med Hypotheses. 2007;69(4):741-5. doi: 10.1016/j.mehy.2006.08.047. Epub 2007 Mar 30. PMID: 17399910.
72. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007 Mar;52(3):827-35. doi:10.1016/j.neuropharm.2006.10. 001. Epub 2006 Nov 22. PMID: 17123556.60. Pelkonen O, Pasanen M, Lindon JC, Chan K, Zhao L, Deal G, Xu Q, Fan TP. Omics and its potential impact on R&D and regulation of complex herbal products. J Ethnopharmacol. 2012 Apr 10;140(3):587-93. doi: 10.1016/j.jep.2012.01.035. Epub 2012 Feb 1. PMID: 22313626.
61. Xu SP, Yang YY, Xue D, Liu JX, Liu XM, Fan TP, le Pan R, Li P. Cognitive-enhancing effects of polygalasaponin hydrolysate in aβ(25-35)-induced amnesic mice. Evid Based Complement Alternat Med. 2011;2011:839720. doi:10.1155/2011/839720. Epub 2011 Mar 6. PMID: 21423642; PMCID: PMC3057668.
62. Yeh JC, Cindrova-Davies T, Belleri M, Morbidelli L, Miller N, Cho CW, Chan K, Wang YT, Luo GA, Ziche M, Presta M, Charnock-Jones DS, Fan TP*. The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo. Angiogenesis. 2011 May;14(2):187-97. doi: 10.1007/s10456-011-9202-8. Epub 2011 Feb 15. PMID: 21327473.
63. Uzuner H, Fan TP, Dias A, Guo DA, El-Nezami HS, Xu Q. Establishing an EU-China consortium on traditional Chinese medicine research. Chin Med. 2010 Dec 14;5:42. doi: 10.1186/1749-8546-5-42. PMID: 21156056; PMCID: PMC3019128.
64. Lee YM, Ting CM, Cheng YK, Fan TP, Wong RN, Lung ML, Mak NK. Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells. Cancer Lett. 2008 Sep 18;268(2):295-307. doi: 10.1016/j.canlet.2008.04.010. Epub 2008 May 19. PMID: 18492602.
65. Li P, Xu G, Li SP, Wang YT, Fan TP, Zhao QS, Zhang QW. Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. JAgric Food Chem. 2008 Feb 27;56(4):1164-71. doi: 10.1021/jf073020u. Epub 2008 Jan 17. PMID: 18198831.
66. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2008 Jan 11;365(2):285-90. doi: 10.1016/j.bbrc.2007.10.166. Epub 2007 Nov 5. PMID: 17986384.
67. Leung KW, Cheung LW, Pon YL, Wong RN, Mak NK, Fan TP, Au SC, Tombran- Tink J, Wong AS. Ginsenoside Rb1 inhibits tube-like structure formation of endothelial cells by regulating pigment epithelium-derived factor through the oestrogen beta receptor. Br J Pharmacol. 2007 Sep;152(2):207-15. doi: 10.1038/sj.bjp.0707359. Epub 2007 Jul 2. Erratum in: Br J Pharmacol. 2020 Jan;177(1):236. PMID: 17603552; PMCID: PMC1978254.
68. Bapna A, Federici L, Venter H, Velamakanni S, Luisi B, Fan TP, van Veen HW. Two proton translocation pathways in a secondary active multidrug transporter. J Mol Microbiol Biotechnol. 2007;12(3-4):197-209. doi: 10.1159/000099641. PMID: 17587868.
69. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan TP, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007 May 15;2:6. doi: 10.1186/1749-8546-2-6. PMID: 17502003; PMCID: PMC1876803.
70. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, NgTB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007;14(12):1371-80. doi: 10.2174/092986707780597916. PMID: 17504218.
71. Lim MW, Fan TP. A "pancreatic tooth" design best accommodates the limitations of current artificial pancreas technology. Med Hypotheses. 2007;69(4):741-5. doi: 10.1016/j.mehy.2006.08.047. Epub 2007 Mar 30. PMID: 17399910.
73. Yue PY, Wong DY, Wu PK, Leung PY, Mak NK, Yeung HW, Liu L, Cai Z, Jiang ZH, Fan TP, Wong RN. The angiosuppressive effects of 20(R)- ginsenoside Rg3. Biochem Pharmacol. 2006 Aug 14;72(4):437-45. doi: 10.1016/j.bcp.2006.04.034. Epub 2006 May 12. PMID: 16793023.
74. Jin J, Shahi S, Kang HK, van Veen HW, Fan TP*. Metabolites of ginsenosides as novel BCRP inhibitors. Biochem Biophys Res Commun. 2006 Jul 14;345(4):1308-14. doi: 10.1016/j.bbrc.2006.04.152. Epub 2006 May 4. PMID: 16729968.
75. Fan TP*, Yeh JC, Leung KW, Yue PY, Wong RN. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006 Jun;27(6):297-309. doi: 10.1016/j.tips.2006.04.006. Epub 2006 May 11. PMID: 16697473.
76. Leung KW, Cheng YK, Mak NK, Chan KK, Fan TP, Wong RN. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett. 2006 May 29;580(13):3211-6. doi: 10.1016/j.febslet.2006.04.080. Epub 2006 May 4. PMID: 16696977.
77. Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of the mechanisms underlying the angiogenic effects of ginsenoside Rg(1) in vivo and in vitro. Angiogenesis. 2005;8(3):205-16. doi: 10.1007/s10456-005-9000-2. Epub 2005 Nov 22. Erratum in: Angiogenesis. 2007;10(1):69. PMID: 16328162.
78. Kok TW, Yue PY, Mak NK, Fan TP, Liu L, Wong RN. The anti-angiogenic effect of sinomenine. Angiogenesis. 2005;8(1):3-12. doi: 10.1007/s10456-005-2892-z. PMID: 16132613.
79. Sengupta S, Sellers LA, Gherardi E, Sasisekharan R, Fan TP*. Nitric oxide modulates hepatocyte growth factor/scatter factor-induced angiogenesis. Angiogenesis. 2004;7(4):285-94. doi: 10.1007/s10456-004-5238-3. Epub 2005 May 9. PMID: 15886872.
80. Sengupta S, Toh SA, Sellers LA, Skepper JN, Koolwijk P, Leung HW, Yeung HW, Wong RN, Sasisekharan R, Fan TP*. Modulating angiogenesis: the yin and the yang in ginseng. Circulation. 2004 Sep 7;110(10):1219-25. doi: 10.1161/01.CIR.0000140676.88412.CF. Epub 2004 Aug 30. PMID: 15337705.
81. Bevan D, Gherardi E, Fan TP, Edwards D, Warn R. Diverse and potent activities of HGF/SF in skin wound repair. J Pathol. 2004 Jul;203(3):831-8. doi: 10.1002/path.1578. PMID: 15221943.
82. van Beijnum JR, Fan TP, Griffioen AW. Eur(omega)conference Angiogenesis II. Angiogenesis. 2003;6(3):159-64. doi: 10.1023/b:agen.0000021513.95526.cb. PMID: 15129652.
83. Bapna A, Vickerstaffe E, Warrington BH, Ladlow M, Fan TP, Ley SV. Polymer- assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors. Org Biomol Chem. 2004 Feb 21;2(4):611-20. doi: 10.1039/b313414h. Epub 2004 Jan 27. PMID: 14770241.
84. Sengupta S, Sellers LA, Cindrova T, Skepper J, Gherardi E, Sasisekharan R, Fan TP*. Cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs inhibit hepatocyte growth factor/scatter factor-induced angiogenesis. Cancer Res. 2003 Dec 1;63(23):8351-9. PMID: 14678996.
85. Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP, Smith SK. Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab. 2003 Jun;88(6):2889-99. doi: 10.1210/jc.2002-021912. PMID: 12788903.
86. Sengupta S, Sellers LA, Li RC, Gherardi E, Zhao G, Watson N, Sasisekharan R, Fan TP*. Targeting of mitogen-activated protein kinases and phosphatidylinositol 3 kinase inhibits hepatocyte growth factor/scatter factor-induced angiogenesis. Circulation. 2003 Jun 17;107(23):2955-61. doi: 10.1161/01.CIR.0000077501. 19266.E5. Epub 2003 Jun 2. PMID: 12782568.
87. Sengupta S, Sellers LA, Matheson HB, Fan TP*. Thymidine phosphorylase induces angiogenesis in vivo and in vitro: an evaluation of possible mechanisms. Br J Pharmacol. 2003 May;139(2):219-31. doi: 10.1038/sj.bjp.0705216. PMID: 12770927; PMCID: PMC1573835.
88. Sengupta S, Gherardi E, Sellers LA, Wood JM, Sasisekharan R, Fan TP*. Hepatocyte growth factor/scatter factor can induce angiogenesis independently of vascular endothelial growth factor. Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):69-75. doi: 10.1161/01.atv.0000048701.86621.d0. PMID: 12524227.
89. Alderton F, Fan TP, Humphrey PP. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001 Feb;132(3):760-6. doi: 10.1038/sj.bjp.0703862. PMID: 11159729; PMCID: PMC1572604.
90. Boyle JJ, Wilson B, Bicknell R, Harrower S, Weissberg PL, Fan TP. Expression of angiogenic factor thymidine phosphorylase and angiogenesis in human atherosclerosis. J Pathol. 2000 Oct;192(2):234-42. doi: 10.1002/1096- 9896(2000)9999:9999<::AID-PATH699>3.0.CO;2-9. PMID: 11004701.
91. Griffioen AW, Fan TP. Merger of Angiogenesis and Angiogenesis Research-heading for a quality journal. Angiogenesis. 1998;2(3):201-2. doi: 10.1023/A:1009289303145. PMID: 14517460.
92. Lauder H, Frost EE, Hiley CR, Fan TP*. Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Angiogenesis. 1998;2(1):67-80. doi: 10.1023/a:1009006527462. PMID: 14517377.
93. Alderton F, Fan TP, Schindler M, Humphrey PP. Rat somatostatin sst2(a) and sst2(b) receptor isoforms mediate opposite effects on cell proliferation. Br J Pharmacol. 1998 Dec;125(8):1630-3. doi: 10.1038/sj.bjp.0702282. PMID: 9886753; PMCID: PMC1565767.
94. Alderton F, Lauder H, Feniuk W, Fan TP, Humphrey PP. Differential effects of somatostatin and angiopeptin on cell proliferation. Br J Pharmacol. 1998 May;124(2):323-30. doi: 10.1038/sj.bjp.0701843. PMID: 9641549; PMCID: PMC1565396.
95. Lauder H, Sellers LA, Fan TP, Feniuk W, Humphrey PP. Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. Br J Pharmacol. 1997 Oct;122(4):663-70. doi: 10.1038/sj.bjp.0701443. PMID: 9375962; PMCID: PMC1564995.
96. Walsh DA, Hu DE, Wharton J, Catravas JD, Blake DR, Fan TP*. Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Br J Pharmacol. 1997 Apr;120(7):1302-11. doi: 10.1038/sj.bjp.0701062. PMID: 9105706; PMCID: PMC1564611.
97. Walsh DA, Hu DE, Mapp PI, Polak JM, Blake DR, Fan TP*. Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma. Histochem J. 1996 Nov;28(11):759-69. doi: 10.1007/BF02272149. PMID: 8968728.
98. Hori Y, Hu DE, Yasui K, Smither RL, Gresham GA, Fan TP*. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Br J Pharmacol. 1996 Aug;118(7):1584-91. doi: 10.1111/j.1476- 5381.1996.tb15578.x. PMID: 8842418; PMCID: PMC1909851.
99. Hu DE, Hiley CR, Fan TP*. Comparative studies of the angiogenic activity of vasoactive intestinal peptide, endothelins-1 and -3 and angiotensin II in a rat sponge model. Br J Pharmacol. 1996 Feb;117(3):545-551. doi: 10.1111/j.1476- 5381.1996.tb15225.x. PMID: 8821547; PMCID: PMC1909324.
100. Lees VC, Fan TP, West DC. Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest. 1995 Aug;73(2):259-66. PMID: 7543630.
101. Michel AD, Chau NM, Fan TP, Frost EE, Humphrey PP. Evidence that [3H]-alpha,beta-methylene ATP may label an endothelial-derived cell line 5'-nucleotidase with high affinity. Br J Pharmacol. 1995 Jul;115(5):767-74. doi: 10.1111/j.1476-5381.1995.tb14999.x. PMID: 8548175; PMCID: PMC1908513.
102. Hu DE, Hiley CR, Smither RL, Gresham GA, Fan TP*. Correlation of 133Xe clearance, blood flow and histology in the rat sponge model for angiogenesis. Further studies with angiogenic modifiers. Lab Invest. 1995 May;72(5):601-10. PMID: 7538184.
103. Moghaddam A, Zhang HT, Fan TP, Hu DE, Lees VC, Turley H, Fox SB, Gatter KC, Harris AL, Bicknell R. Thymidine phosphorylase is angiogenic and promotes tumor growth. Proc Natl Acad Sci USA. 1995 Feb 14;92(4):998-1002. doi:10.1073/pnas.92.4.998. PMID: 7532308; PMCID: PMC42624.
104. Fan TP*, Jaggar R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci. 1995 Feb;16(2):57-66. doi: 10.1016/s0165-6147(00)88979-8. PMID: 7539171.
105. Hu DE, Fan TP*. Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat. Inflammation. 1995 Feb;19(1):39-54. doi:10.1007/BF01534379. PMID: 7535750.
106. Hu DE, Fan TP*. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. doi: 10.1111/j.1476-5381.1995.tb13221.x. PMID: 7533611; PMCID: PMC1510224.
107. Lees VC, Fan TP. A freeze-injured skin graft model for the quantitative study of basic fibroblast growth factor and other promoters ofangiogenesis in wound healing. Br J Plast Surg. 1994 Jul;47(5):349-59. doi: 10.1016/0007- 1226(94)90095-7. PMID: 7522103.
108. Braddock PS, Hu DE, Fan TP, Stratford IJ, Harris AL, Bicknell R. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer. 1994 May;69(5):890-8. doi: 10.1038/bjc.1994.172. PMID: 7514028; PMCID: PMC1968907.
109. Hu DE, Hori Y, Presta M, Gresham GA, Fan TP*. Inhibition of angiogenesis in rats by IL-1 receptor antagonist and selected cytokine antibodies. Inflammation. 1994 Feb;18(1):45-58. doi: 10.1007/BF01534597. PMID: 7515856.
110. Fan TP*. Angiosuppressive therapy for cancer. Trends Pharmacol Sci. 1994 Feb;15(2):33-6. doi: 10.1016/0165-6147(94)90103-1. PMID: 7513100.
111. Wren AD, Hiley CR, Fan TP*. Endothelin-3 mediated proliferation in wounded human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1993 Oct 15;196(1):369-75. doi: 10.1006/bbrc.1993.2258. PMID: 8216314.
112. Fan TP*, Hu DE, Guard S, Gresham GA, Watling KJ. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol. 1993 Sep;110(1):43-9. doi: 10.1111/j.1476-5381.1993.tb13769.x. PMID: 7693287; PMCID: PMC2176009.
113. Hu DE, Fan TP*. [Leu8]des-Arg9-bradykinin inhibits the angiogenic effect of bradykinin and interleukin-1 in rats. Br J Pharmacol. 1993 May;109(1):14-7. doi:10.1111/j.1476-5381.1993.tb13525.x. PMID: 7684297; PMCID: PMC2175594.
114. Hu DE, Hori Y, Fan TP*. Interleukin-8 stimulates angiogenesis in rats. Inflammation. 1993 Apr;17(2):135-43. doi: 10.1007/BF00916100. PMID: 7684027.
115. Fan TP*, Frost EE, Wren AD. A multichannel wounding device for the study of vascular repair in vitro. EXS. 1992; 61:315-20. doi: 10.1007/978-3-0348-7001-6_50. PMID: 1377550.
116. Fan TP*, Hu DE, Smither RL, Gresham GA. Further studies on angiogenesis in a rat sponge model. EXS. 1992; 61:308-14. doi: 10.1007/978-3-0348-7001-6_ 49. PMID: 1377549.
117. Smither RL, Fan TP*. Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. EXS. 1992; 61:230-4. doi: 10.1007/978-3-0348-7001- 6_35. PMID: 1319778.
118. Dinh Xuan AT, Fan TP, Higenbottam TW, Wallwork J. Cyclosporine in vitro reduces endothelium-dependent relaxation to acetylcholine but does not affect relaxation to nitrovasodilators. Transplant Proc. 1990 Aug;22(4):1723-5. PMID: 2389442.
119. Andrade SP, Fan TP, Lewis GP. Quantitative in-vivo studies on angiogenesis in a rat sponge model. Br J Exp Pathol. 1987 Dec;68(6):755-66. PMID: 2447929;
PMCID: PMC2013085.
120. Lo WW, Fan TP*. Histamine stimulates inositol phosphate accumulation via the H1-receptor in cultured human endothelial cells. Biochem Biophys Res Commun. 1987 Oct 14;148(1):47-53. doi: 10.1016/0006-291x(87)91074-6. PMID: 3675593.
121. Fan TP*, Cox JH, Chisholm PM. Mechanism of action of cyclosporine in preventing cardiac allograft rejection. II. Graft tissue levels of prostacyclin and thromboxane. Transplantation. 1987 Mar;43(3):343-5. doi: 10.1097/00007890- 198703000-00004. PMID: 3547787.
122. Cole OF, Fan TP, Lewis GP. Release of eicosanoids from cultured rat aortic endothelial cells; studies with arachidonic acid and calcium ionophore A23187. Cell Biol Int Rep. 1986 Jun;10(6):407-13. doi: 10.1016/0309-1651(86)90035-4. PMID: 3091278.
123. Cole OF, Fan TP, Lewis GP. Isolation, characterisation, growth and culture of endothelial cells from the rat aorta. Cell Biol Int Rep. 1986 Jun;10(6):399-405. doi: 10.1016/0309-1651(86)90034-2. PMID: 3017582.
124. Fan TP*, Lewis GP. Mechanism of cyclosporin A-induced inhibition of prostacyclin synthesis by macrophages. Prostaglandins. 1985 Nov;30(5):735-47. doi:10.1016/0090-6980(85)90004-8. PMID: 3936119.
125. Fan TP*, Lewis GP. Effect of cyclosporin A and inhibitors of arachidonic acid metabolism on blood flow and cyclo-oxygenase products in rat skin allografts. Br J Pharmacol. 1984 Feb;81(2):361-71. doi: 10.1111/j.1476-5381.1984. tb10087.x.PMID: 6423022; PMCID: PMC1986882.
126. Fan TP*, Lewis GP. Blood flow, histamine content and histidine decarboxylase activity in rat skin grafts and their modification by cyclosporin-A. Br J Pharmacol. 1982 Jul;76(3):491-7. doi: 10.1111/j.1476-5381.1982.tb09244.x. PMID: 7049288; PMCID: PMC2071795.
