Affiliation：

Contact details

Telephone

 15866683436

Email

wlzh1106@126.com

Address

Biology Institute

Qilu University of Technology (Shandong Academy of Sciences)

Jinan 250103, Shandong Province, China

Biography

Lizhen Wang received his B.S. degree in Chemical Engineering from Qilu University of Technology in 2007, and obtained his M.S. degree in applied chemistry from Qilu University of Technology in 2010. Later, he worked in XuanZhu Pharma Co., Ltd., a company focused on new drug development. In 2012, He joined the Zhongwu Guo lab in Shandong University for his research on the development of glycoconjugate vaccines and got his Ph.D. degree in 2016. Then, he took a position in Biology Institute of Shandong Academy of Sciences. His current research focus is the development of naturally occurred biomolecules and their biological investigations in zebrafish model.

Research

Structural modification of natural products and their biological investigation in vitro and in vivo. 

Funding (year, title, source, amount, role)

Publications

1. Lizhen Wang, Shaojie Feng, Lian An, Guofeng Gu*, and Zhongwu Guo*, Synthetic and Immunological Studies of Mycobacterial Lipoarabinomannan Oligosaccharides and Their Protein Conjugates. J. Org. Chem., 2015, 80: 10060. 

2. Lizhen Wang, Shaojie Feng, Subo Wang, Hui Li, Zhongwu Guo*, and Guofeng Gu*, Synthesis and Immunological Comparison of Differently Linked Lipoarabinomannan Oligosaccharide-Monophosphoryl Lipid A Conjugates as Anti-Tuberculosis Vaccines. J. Org. Chem., 2017, 82: 12085. 

3. Liwen Han, Wenlong Sheng, Xiaobin Li, Attila Sik, Houwen Lin, Kechun Liu,* Lizhen Wang*. Novel carbohydrate modified berberine derivatives: Synthesis and in vitro anti-diabetic investigation. MedChemComm2019,10,598-605.

4. Geng Yang, Xia Meng, Shimin Fang, Hongdong Duan,* Lizhen Wang,* Zhenzheng Wang. A highly selective colorimetric fluorescent probe for detection of Hg2+ and its application on test strips. RSC Adv., 2019, 9, 8529–8536.

5. Lizhen Wang* & Zhongwu Guo*. An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part I: Synthetic studies on arabinofuranosyl oligosaccharides. Journal of Carbohydrate Chemistry,2019, 38(5-6), 269-334

6. Liwen Han, Lizhen Wang* & Zhongwu Guo*. An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part II: Synthetic studies on complex arabinofuranosyl oligosaccharides carrying other functional motifs and related derivatives and analogs. Journal of Carbohydrate Chemistry, 2019, 38(5-6), 335-382

7. Kechun Liu, Lizhen Wang,* & Zhongwu Guo.* An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides–part III: synthetic studies and biological applications of arabinofuranosyl oligosaccharides and their analogs, derivatives and conjugates. Journal of Carbohydrate Chemistry,2019, 38(7-8), 414-469.

8. Jun Xie, Dawei Qin,* Yanhong Han, Lizhen Wang.* Synthesis and characterization of a novel hydroxypropyl chitosan-graft-β-Cyclodextrin copolymer as potential drug carrier. Journal of Carbohydrate Chemistry, 2019, 38(5-6), 383-397.

9. Wang, L.; Kong, H.; Jin, M.; Li, X.-B.; Stoika, R.; Lin, H.-w.; Liu, K*. Synthesis of disaccharide modified berberine derivatives and their anti-diabetic investigation in zebrafish using a fluorescence-based technology. Organic & Biomolecular Chemistry, 2020, 18, 3575-3584

10. Wang, L.; Zhang, J.; An, X.; Duan, H*. Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems. Organic & Biomolecular Chemistry 2020, 18, 1522.

11. Lizhen Wang, Xueliang Yang, Xiaobin Li, Rostyslav Stoika, Xue Wang, Houwen Lin, Yukui Ma, Rongchun Wang* and Kechun Liu*, Synthesis of hydrophobically modified berberine derivatives with high anticancer activity through modulation of the MAPK pathway, New J. Chem., 2020, 44, 14024-14034

12. Rongchun Wang, Stoyka Rostyslav, Xiaobin Li, Houwen Lin, Xuanming Zhang, Shanshan Zhang, Kechun Liu* & Lizhen Wang*. Synthetic and antitumor comparison of 9-O-alkylated and carbohydrate-modified berberine derivatives. J. IRAN. CHEM. SOC. 2020, https://doi.org/10.1007/s13738-020-01985-0

13. Zhang, B.; Wang, L.; Ji, X.; Zhang, S.; Sik, A.; Liu, K.; Jin, M. Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of Neuroimmune Pharmacology 2020, DOI: https://doi.org/10.1007/s11481-019-09902-w.

14. Hongdong Duan*, Lizhen Wang, Dawei Qin, Xiaomeng Li, Shixiao Wang, and Yi Zhang, Synthesis and characterization of some new star-shaped polydentate ligands from 2,4,6-trichloro-1,3,5-triazine. Synthetic Communications, 2011, 41: 380. 

15. Yuchuan Guo, Lizhen Wang, Jiatong Guo, Guofeng Gu*, and Zhongwu Guo*, Biochemical Studies of Inositol N-Acetylglucosaminyltransferase Involved in Mycothiol Biosynthesis in Corynebacterium diphtheria. Organic & Biomolecular Chemistry, 2017, 15: 3775 

16. Yuchuan Guo,§ Wei Gong,§ Lizhen Wang, Jiatong Guo, Guoxia Jin, Guofeng Gu* and Zhongwu Guo*, Characterization and biochemical investigation of the potential inositol monophosphate phosphatase involved in bacterial mycothiol biosynthesis. Journal of Carbohydrate Chemistry, 2018, 37, 507

17. Xueyun Geng, Lizhen Wang, Guofeng Gu*, and Zhongwu Guo*. Synthesis of a Trisaccharide Repeating Unit of the O-Antigen from Burkholderia anthina and Its Dimer, Carbohydrate Research, 2016, 427: 13. 

18. Jian Gao, Guochao Liao, Lizhen Wang, Zhongwu Guo*, Synthesis of a Miniature Lipoarabinomannan. Org. Lett., 2014, 16: 988. 

Patents

Awards and other activities