Affiliation：

Key Laboratory for Drug Screening Technology,

Biology Institute of Shandong Academy of Sciences

 

Contact details

Telephone

+86-13127104334

Email

mjin1985@hotmail.com

Address

28789 East Jingshi Road, Jinan 250103, Shandong Province, P.R. China

Biography

Meng Jin, associate professor, research supervisor. She received her Ph.D. from Shandong University, China in 2013 and specialized in various biological subjects related to development and differentiation of optic nerve in Baylor College of Medicine in the United States for five years. She is the Head of the Human Disease Model Generation and Drug Screening Laboratory at the Biology Institute of Shandong Academy of Sciences. Prof. Meng Jin is mainly engaged in the generation of models of human neurological diseases, zebrafish model-based screening and safety evaluation of drugs which have neuroprotective activity, and underlying mechanism investigation. The neurological diseases include epilepsy, Parkinson’s disease, and Alzheimer's Disease. 

Prof. Meng Jin has participated in two research programs funded by National Natural Science fund as the PI, three research programs funded by Shandong Academy of Sciences as the PI. She has also participated in more than 10 provincial level programs and 4 international research programs. As the first author and the corresponding author, she published 18 SCI papers. 

Research

The research fields include:

1. Generation of human neurological disease models and therapeutic approach investigation. The neurological diseases include epilepsy, Parkinson’s disease, and Alzheimer's Disease. 

2. Screening, evaluation, and mechanism investigation of natural compounds from traditional Chinese herbs which have neuroprotective potential.

3. Safety or toxicity evaluation of drugs and environmental pollutants which may exhibit adverse effects on the nervous system.

 

Funding (year, title, source, amount, role)

1. The mechanism study of breast cancer invasion and metastasis regulated by interaction between EYA2 and PAX6 (National Natural Science Foundation of China, No. 81802629, 2019.01-2021.12, 210000 RMB, PI).

2. Research and development of a novel Ii-key peptide vaccine based on the Key antigen epitopes of coronavirus (National Program for The Introduction of High-end Foreign Experts by the Ministry of Science and Technology of China, 2020.01-2021.01, 500000 RMB, PI)

3. The mechanism study of breast cancer MCF7 invasion and metastasis regulated by protein interaction (Youth Fund of Shandong Academy of Sciences, No. 2018QN0024, 2018.01-2019.12, 100000 RMB, PI).

4. Retinal Cell-Fate Determination and Pattern Formation (National Eye Institute, No. R01 EY011232, 2016.05-2020.04, 10960000 RMB, researcher).

 

Publications

1. Jin M, Ji X, Stoika R, Liu K, Wang L, Song Y: Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study. Bioorganic chemistry 2020, 101:104021.

2. Jin M, Gao D, Wang R, Sik A, Liu K: Possible involvement of TGFbetaSMADmediated epithelialmesenchymal transition in prometastatic property of PAX6. Oncology reports 2020, 44(2):555-564.

3. Jin M, Zhang B, Sun Y, Zhang S, Li X, Sik A, Bai Y, Zheng X, Liu K: Involvement of peroxisome proliferator-activated receptor gamma in anticonvulsant activity of alpha-asaronol against pentylenetetrazole-induced seizures in zebrafish. Neuropharmacology 2020, 162:107760.

4. Li X, Dang J, Li Y, Wang L, Li N, Liu K, Jin M: Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method. The Science of the total environment 2020, 752:141878.

5. Zhang S, Yu Z, Xia J, Zhang X, Liu K, Sik A, Jin M: Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism. Food & function 2020, 11(2):1425-1440.

6. Zhang B, Wang L, Ji X, Zhang S, Sik A, Liu K, Jin M: Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of neuroimmune pharmacology 2020, 15(2):309-325.

7. Shang X, Ji X, Dang J, Wang L, Sun C, Liu K, Sik A, Jin M: alpha-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Toxicology letters 2020, 324:1-11.

8. Li X, Ji X, Wang R, Zhao J, Dang J, Gao Y, Jin M: Zebrafish behavioral phenomics employed for characterizing behavioral neurotoxicity caused by silica nanoparticles. Chemosphere 2020, 240:124937.

9. Jin M, Xiao Z, Zhang S, Men X, Li X, Zhang B, Zhou T, Hsiao CD, Liu K: Possible involvement of Fas/FasL-dependent apoptotic pathway in alpha-bisabolol induced cardiotoxicity in zebrafish embryos. Chemosphere 2019, 219:557-566.

10. Jin M, Ji X, Zhang B, Sheng W, Wang R, Liu K: Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish. Ecotoxicology and environmental safety 2019, 172:460-470.

11. Li X, Kong H, Ji X, Gao Y, Jin M: Zebrafish behavioral phenomics applied for phenotyping aquatic neurotoxicity induced by lead contaminants of environmentally relevant level. Chemosphere 2019, 224:445-454.

12. Li X, Zhang B, Li N, Ji X, Liu K, Jin M: Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere 2019, 231:315-325.

13. Jin M, Sheng W, Han L, He Q, Ji X, Liu K: Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish. Fish & shellfish immunology 2018, 83:26-36.

14. Jin M, He Q, Zhang S, Cui Y, Han L, Liu K: Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish. Neurochemical research 2018, 43(4):904-917.

15. Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G: Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets. Developmental biology 2016, 415(1):157-167.

16. Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G: Conditional knockout of retinal determination genes in differentiating cells in Drosophila. The FEBS journal 2016, 283(15):2754-2766.

17. Jin M, Mardon G: Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development. Scientific reports 2016, 6:23228.

18. Jin M, Jusiak B, Bai Z, Mardon G: Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival. PloS one 2013, 8(3):e58818.

 

Awards and other activities

2011-2013, Visiting Scholar, China Scholarship council.

2016, Introduced talents, Shandong Academy of Sciences.

Reviewers of journal papers: Neurotoxicity Research, Fish and shellfish immunology, Environmental Science-Nano, Science of the Total Environment, Environmental Science and Pollution Research, JoVE, and Drug Design, Development and Therapy.